Læknablaðið - 15.06.2009, Síða 18

F R Æ Ð I G R E I
RANNSÓKN
N A R
12. Semmens JB, Platell C, Threlfall TJ, Holman CD. A
population-based study of the incidence, mortality and
outcomes in patients following surgery for colorectal cancer
in Western Australia. Aust N Z J Surg 2000; 70:11-8.
13. Faivre-Finn C, Bouvier-Benhamiche AM, Phelip JM,
Manfredi S, Dancourt V, Faivre J. Colon cancer in France:
evidence for improvement in management and survival.
Gut 2002; 51:60-4.
14. Keating J, Pater P, Lolohea S, Wickremesekera K. The
epidemiology of colorectal cancer: what can we learn from
the New Zealand Cancer Registry? N Z Med J 2003; 116:
U437.
15. The Cancer Registry of Norway. Cancer in Norway 2000.
Norway 2003.
16. Gatta G, Ciccolallo L, Capocaccia R, et al. Differences
in colorectal cancer survival between European and US
populations: the importance of sub-site and morphology.
Eur J Cancer 2003; 39: 2214-22.
17. Hagstofa íslands. Hagstofa íslands - Hagtölur. 2007; www.
hagstofa.is / júní 2007.
18. Malila N, Hakulinen T. Epidemiological trends of colorectal
cancer in the Nordic countries. Scand J Surg 2003; 92: 5-9.
19. Davidson NO. Genetic testing in colorectal cancer: who,
when, how and why. Keio J Med 2007; 56:14-20.
20. Ferlay J, Engholm G, Storm HH, Ferlay J, Christensen N.
Association of the Nordic Cancer Registries. 2008; www.
ancr.nu/nordcan.asp /september 2008.
21. Heys SD, O'Hanrahan TJ, Brittenden J, Eremin O. Colorectal
cancer in young patients: a review of the literature. Eur J
Surg Oncol 1994; 20: 225-31.
22. Eker R. Some Prognostic Factors for Carcinomas of the
Colon and Rectum. Acta Chir Scand 1963; 126: 636-56.
23. Jessup JM, McGinnis LS, Steele GD Jr, Menck HR, Winchester
DP. The National Cancer Data Base. Report on colon cancer.
Cancer 1996; 78: 918-26.
24. Mostafa G, Matthews BD, Norton HJ, Kercher KW, Sing
RF, Heniford BT. Influence of demographics on colorectal
cancer. Am Surg 2004; 70: 259-64.
25. Newland RC, Dent OF, Lyttle MN, Chapuis PH, Bokey
EL. Pathologic determinants of survival associated with
colorectal cancer with lymph node metastases. A multivariate
analysis of 579 patients. Cancer 1994; 73: 2076-82.
26. Sasaki O, Atkin WS, Jass JR. Mucinous carcinoma of the
rectum. Histopathology 1987; 11: 259-72.
27. Jass JR. Lymphocytic infiltration and survival in rectal
cancer. J Clin Pathol 1986; 39: 585-9.
28. Angell-Andersen E, Tretli S, Coleman MP, Langmark F,
Grotmol T. Colorectal cancer survival trends in Norway
1958-1997. Eur J Cancer 2004; 40: 734-42.
29. Scheiden R, Pescatore P, Wagener Y, Kieffer N, Capesius C.
Colon cancer in Luxembourg: a national population-based
data report, 1988-1998. BMC Cancer 2005; 5: 52-63.
30. Kotake K, Honjo S, Sugihara K, et al. Changes in colorectal
cancer during a 20-year period: an extended report from the
multi-institutional registry of large bowel cancer, Japan. Dis
Colon Rectum 2003; 46 (10 Suppl): S32-43.
31. Han-Shiang C. Curative resection of colorectal
adenocarcinoma: multivariate analysis of 5-year follow-up.
World J Surg 1999; 23:1301-6.
32. Steinberg SM, Barwick KW, Stablein DM. Importance of
tumor pathology and morphology in patients with surgically
resected colon cancer. Findings from the Gastrointestinal
Tumor Study Group. Cancer 1986; 15; 58:1340-5.
33. Ropponen K, Eskelinen M, Kosma VM, Lipponen P,
Paakkinen P, Alhava E. Comparison of classic and
quantitative prognostic factors in colorectal cancer.
Anticancer Res 1996; 16(6B): 3875-82.
34. Takeuchi K, Kuwano H, Tsuzuki Y, et al. Clinicopathological
characteristics of poorly differentiated adenocarcinoma of
the colon and rectum. Hepatogastroenterology 2004; 51:
1698-702.
35. Gerhardsson M, Steineck G, Norell SE. Colorectal cancer
in Sweden. A descriptive epidemiologic study. Acta Oncol
1990; 29: 855-61.
36. Helgason A, Yngvadóttir B, Hrafnkelsson B, Gulcher
J, Stefánsson K. An Icelandic example of the impact of
population structure on association studies. Nat Genet 2005;
37: 90-5.
37. Nelson RL, Dollear T, Freels S, Persky V. The relation of
age, race, and gender to the subsite location of colorectal
carcinoma. Cancer 1997; 80:193-7.
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Colon cancer in lceland 1955-2004. Study on epidemiology,
histopathology and gender difference
Objective: Colon cancer is the third most common
cancer in lceland. The aim of this study was to analyze
the epidemiology and histopathology of colon cancer in
lceland, resection rate and the difference between men
and women.
Material and methods: Pathology and autopsy reports
for all patients diagnosed with colon cancer between
1955 and 2004 where reviewed. All the histopathology
material was re-evaluated. Demographical information and
pathological findings were registered. Age-standardized
incidence was calculated for both men and women.
Gender difference was evaluated. Time trend was
evaluated by linear regression.
Results: After re-evaluation 2293 cases remained (1148
males and 1145 females). The incidence increased
for men from 7.5, to 22.2/105 and for women from 8.6
to 15.1/105. Most tumors were located in the sigmoid
colon (35%). Surgical rate increased from 50% to
85%. Adenocarcinomas where 84% and mucinous
adenocarcinoma 7%. Altogether 7% of cases were TNM-
stage I, 32% were stage II, 24% stage III, 21% in stage IV
and stage was unknown in 16% of cases. Slight gender
difference was observed regarding grade, vessel invasion,
depth of invasion and anatomic subsite.
Conclusion: Incidence of colon cancer increased
considerably, mainly for men. Surgical rate and pathology
of colon cancer is similar to that reported elsewhere except
that there are somewhat fewer cases in TNM-stage I.
Little gender difference was observed in the pathological
parameters analysed.
Snaebjornsson P, Jonasson L, Jonsson Th, Moller PH, Theodors A, Jonasson JG.
Colon cancer in lceland 1955-2004. Study on epidemiology, histopathology and gender difference. Icel Med J 2009; 95; 423-30
Key words: colon cancer, histopathology, epidemiology, gender, population-based.
Correspondence: Jón Gunntaugur Jónasson, jongj@landspitali.is
Barst: 3. febrúar 2009, - samþykkt til birtingar: 29. apríl 2009
430 LÆKNAblaðið 2009/95