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Drug-induced liver injury
Drug-induced liver injury (DILI) is a well known adverse
reaction of many drugs. Direct toxic liver damage is
associated with paracetamol toxicity whereas most other
drugs causing liver damage have an unpredictable or
idiosyncratic pattern of injury. Although idiosyncratic liver
injury was initially thought to be dose independent, it has
been shown that many drugs leading to idiosyncratic
injury have a dose dependent component. Physicians
need to bear in mind DILI in ali patients who present with
Bjornsson ES.
Drug-induced liver injury. Icel J Med 2010; 96: 167-74
Key words: Drug-induced liverinjury
Correspondence: EinarS. Björnsson, einarsb@iandspitati.is
symptoms or signs of liver dysfunction. Clinically and
histologically DILI can mimick any known liver disease
and there are no pathognomonic histological features of
DILI. The diagnosis is one of exclusion. In patients with
a high clinical suspicion of DILI the causative drug need
to be discontinued and patients with jaundice and/or
coagulopathy have to be hospitalized and some cases
considered for a liver transplantation.
Barst: 16. október 2009, - samþykkt til birtingar: 4. desember 2009
Hagsmunatengsl: Engin
1 82 LÆKNAblaðið 2010/96