Læknablaðið

Árgangur

Læknablaðið - apr. 2019, Blaðsíða 30

Læknablaðið - apr. 2019, Blaðsíða 30
182 LÆKNAblaðið 2019/105 Tómas Guðbjartsson1,3 Anders Jeppsson2 Wound infections are common complications after open heart sur- gery, both in the sternotomy and vein harvest wound. Fortunately, most of these infections are superficial and respond to minor wound debridement and antibiotics, however, 1-3% of patients develop deep sternal wound infection with mediastinis; an infection that can be fatal. Late infections with sternocutaneous fistulas are encoun- tered less often, but also represent a complex surgical problem. The vein harvest site is the most common site for wound infections after cardiac surgery and these infections result in signifi- cant patient morbidity and increases health-care costs. This evidence-based review covers etiology, risk factors, preven- tion and treatment of wound infections following open heart surgery with special focus on advances in treatment, especially negative- pressure wound therapy. Wound infections following open heart surgery - review ENGLISH SUMMARY 1Department of Cardiothoracic Surgery, Landspitali University Hospital, 2Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, 3Faculty of Medicine, Uni- versity of Iceland. Key words: Wound infections, Cardiac surgery, Deep sternal wound infection, treatment, negative pressure wound therapy. Correspondence: Tómas Guðbjartsson, tomasgudbjartsson@hotmail.com 21. Hallgrímsdóttir H, Gottfreðsson M, Guðbjartsson T. Framsýn rannsókn á skurðsýkingum eftir 246 opnar hjartaaðgerðir (E200). Læknablaðið (Fylgirit 66) 2011; 97. 22. Exarhos DN, Malagari K, Tsatalou EG, Benakis SV, Peppas C, Kotandidou A, et al. Acute mediastinitis: spectrum of computed tomography findings. Eur Radiol 2005; 15: 1569-74. 23. Steingrimsson S, Gottfredsson M, Kristinsson KG, Gudbjartsson T. Deep sternal wound infections following open heart surgery in Iceland: a population-based study. Scand Cardiovasc J 2008; 42: 208-13. 24. Borger MA, Rao V, Weisel RD, Ivanov J, Cohen G, Scully HE, et al. Deep sternal wound infection: risk factors and outcomes. Ann Thorac Surg 1998; 65: 1050-6. 25. Sjögren J, Gustafsson R, Nilsson J, Malmsjö M, Ingemansson R. Clinical outcome after poststernotomy mediastinitis: vacuum-assisted closure versus con- ventional treatment. Ann Thorac Surg 2005; 79: 2049-55. 26. Dai C, Lu Z, Zhu H, Xue S, Lian F. Bilateral internal mammary artery grafting and risk of sternal wound infect- ion: evidence from observational studies. Ann Thorac Surg 2013; 95: 1938-45. 27. Itagaki S, Cavallaro P, Adams DH, Chikwe J. Bilateral internal mammary artery grafts, mortality and morbidity: an analysis of 1 526 360 coronary bypass operations. Heart 2013; 99: 849-53. 28. Kajimoto K, Yamamoto T, Amano A. Coronary artery bypass revascularization using bilateral internal thoracic arteries in diabetic patients: a systematic review and meta- analysis. Ann Thorac Surg 2015; 99: 1097-104. 29. Furnary AP, Zerr KJ, Grunkemeier GL, Starr A. Continuous intravenous insulin infusion reduces the incidence of deep sternal wound infection in diabetic pati- ents after cardiac surgical procedures. Ann Thorac Surg 1999; 67: 352-60; discussion 60-2. 30. Dodds Ashley ES, Carroll DN, Engemann JJ, Harris AD, Fowler VG jr, Sexton DJ, et al. Risk factors for postoperative mediastinitis due to methicillin-resistant Staphylococcus aureus. Clin Infect Dis 2004; 38:1 555-60. 31. Steingrimsson S, Gottfredsson M, Gudmundsdottir I, Sjögren J, Gudbjartsson T. Negative-pressure wound therapy for deep sternal wound infections reduces the rate of surgical interventions for early re-infections. Interact Cardiovasc Thorac Surg 2012; 15: 406-10. 32. European Antimicrobial Resistance Surveillance Network (EARS-Net). ecdc.europa.eu/en/healthtopics/antimicrobi- al_resistance/database/Pages/map_reports.aspx - janúar 2019. 33. Bryant LR, Spencer FC, Trinkle JK. Treatment of median sternotomy infection by mediastinal irrigation with an antibiotic solution. Ann Surg 1969; 169: 914-20. 34. Petzina R, Hoffmann J, Navasardyan A, Malmsjö M, Stamm C, Unbehaun A, et al. Negative pressure wound therapy for post-sternotomy mediastinitis reduces morta- lity rate and sternal re-infection rate compared to con- ventional treatment. Eur J Cardiothorac Surg 2010; 38: 110-3. 35. Sjögren J, Nilsson J, Gustafsson R, Malmsjö M, Ingemansson R. The impact of vacuum-assisted closure on long-term survival after post-sternotomy mediastinitis. Ann Thorac Surg 2005; 80: 1270-5. 36. Guðmundsdóttir I, Steingrímsson S, Valsdóttir E, Guðbjartsson T. Sárasogsmeðferð - yfirlitsgrein. Læknablaðið 2014; 100: 219-24. 37. Glass GE, Murphy GF, Esmaeili A, Lai LM, Nanchahal J. Systematic review of molecular mechanism of action of negative-pressure wound therapy. Brit J Surg 2014; 101: 1627-36. 38. Wackenfors A, Gustafsson R, Sjögren J, Algotsson L, Ingemansson R, Malmsjö M. Blood flow responses in the peristernal thoracic wall during vacuum-assisted closure therapy. Ann Thorac Surg 2005; 79: 1724-30; discussion 30-1. 39. Malmsjö M, Gustafsson L, Lindstedt S, Gesslein B, Ingemansson R. The effects of variable, intermittent, and continuous negative pressure wound therapy, using foam or gauze, on wound contraction, granulation tissue formation, and ingrowth into the wound filler. Eplasty 2012; 12: e5. 40. Mokhtari A, Petzina R, Gustafsson L, Sjögren J, Malmsjö M, Ingemansson R. Sternal stability at different negative pressures during vacuum-assisted closure therapy. Ann Thorac Surg 2006; 82: 1063-7. 41. Borgquist O, Ingemansson R, Malmsjö M. The influence of low and high pressure levels during negative-pressure wound therapy on wound contraction and fluid evacu- ation. Plast Reconstr Surg 2011; 127: 551-9. 42. Gudbjartsson T, Sigurdsson HK, Sigurdsson E, Kjartansson J. Vacuum-Assisted Closure for Successful Treatment of a Major Contaminated Gunshot Chest-Wound: A Case Report. Eur J Trauma Emerg Surg 2008; 34: 508. 43. Gustafsson R, Johnsson P, Algotsson L, Blomquist S, Ingemansson R. Vacuum-assisted closure therapy guided by C-reactive protein level in patients with deep sternal wound infection. J Thorac Cardiovasc Surg2002; 123: 895- 900. 44. Sjögren J, Gustafsson R, Nilsson J, Lindstedt S, Nozohoor S, Ingemansson R. Negative-pressure wound therapy following cardiac surgery: bleeding complications and 30-day mortality in 176 patients with deep sternal wound infection. Interact Cardiovasc Thorac Surg 2011; 12: 117- 20. 45. Gustafsson RI, Sjögren J, Ingemansson R. Deep sternal wound infection: a sternal-sparing technique with vacuum-assisted closure therapy. Ann Thorac Surg 2003; 76: 2048-53; discussion 53. 46. Baillot R, Cloutier D, Montalin L, Coté L, Lellouche F, Houde C, et al. Impact of deep sternal wound infection management with vacuum-assisted closure therapy foll- owed by sternal osteosynthesis: a 15-year review of 23,499 sternotomies. Eur J Cardiothorac Surg 2010; 37: 880-7. 47. Tarzia V, Carrozzini M, Bortolussi G, Buratto E, Bejko J, Comissio M et al. Impact of vacuum-assisted closure therapy on outcomes of sternal wound dehiscencedagger. Interact Cardiovasc Thorac Surg 2014; 19: 70-5. 48. Petursdottir A, Gudbjartsson T. Deep wound infections in Iceland 1996-2018. In submission (verður lagfært) 49. Jideus L, Liss A, Stahle E. Patients with sternal wound infection after cardiac surgery do not improve their quality of life. Scand Cardiovasc J 2009; 43: 194-200. 50. Graf K, Ott E, Vonberg RP, Kuehn C, Haverich A, Chaberny IF. Economic aspects of deep sternal wound infections. Eur J Cardiothorac Surg 2010; 37: 893-6. 51. Braxton JH, Marrin CA, McGrath PD, Morton JR, Norotsky M, Charlesworth DC, et al. 10-year follow-up of patients with and without mediastinitis. Semin Thorac Cardiovasc Surg 2004; 16: 70-6. 52. Sarr MG, Gott VL, Townsend TR. Mediastinal infection after cardiac surgery. Ann Thorac Surg 1984; 38: 415-23. 53. Sjögren J, Malmsjö M, Gustafsson R, Ingemansson R. Poststernotomy mediastinitis: a review of conventional surgical treatments, vacuum-assisted closure therapy and presentation of the Lund University Hospital mediastinit- is algorithm. Eur J Cardiothorac Surg 2006; 30: 898-905. 54. Ubbink DT, Westerbos SJ, Nelson EA, Vermeulen H. A systematic review of topical negative pressure therapy for acute and chronic wounds. Brit J Surg 2008; 95: 685-92. 55. Peinemann F, McGauran N, Sauerland S, Lange S. Negative pressure wound therapy: potential publication bias caused by lack of access to unpublished study results data. BMC Med Res Methodol 2008; 8: 4. 56. Mokhtari A, Sjögren J, Nilsson J, Gustafsson R, Malmsjö M, Ingemansson R. The cost of vacuum-assisted closure therapy in treatment of deep sternal wound infection. Scand Cardiovasc J 2008; 42: 85-9. 57. Tocco MP, Ballardini M, Masala M, Perozzi A. Post- sternotomy chronic osteomyelitis: is sternal resection always necessary? Eur J Cardiothorac Surg 2013; 43: 715- 21. 58. Jones G, Jurkiewicz MJ, Bostwick J, Wood R, Bried JT, Culbertson J, et al. Management of the infected median sternotomy wound with muscle flaps. The Emory 20-year experience. Ann Surg 1997; 225: 766-76; discussion 76-8. 59. Vestergaard RF, Jensen H, Vind-Kezunovic S, Jakobsen T, Soballe K, Hasenkam JM. Bone healing after median sternotomy: a comparison of two hemostatic devices. J Cardiothorac Surg 2010; 5: 117. 60. Bakaeen FG, Zenati MA, Bhatt DL. Conduits in coronary artery bypass grafting. Semin Thorac Cardiovasc Surg 2013; 25: 273-9. Heimildir 61-80 eru á heimasíðu blaðsins. Barst til blaðsins 29. desember 2018, samþykkt til birtingar 12. mars 2019. Y F I R L I T S G R E I N

x

Læknablaðið

Beinir tenglar

Ef þú vilt tengja á þennan titil, vinsamlegast notaðu þessa tengla:

Tengja á þennan titil: Læknablaðið
https://timarit.is/publication/986

Tengja á þetta tölublað:

Tengja á þessa síðu:

Tengja á þessa grein:

Vinsamlegast ekki tengja beint á myndir eða PDF skjöl á Tímarit.is þar sem slíkar slóðir geta breyst án fyrirvara. Notið slóðirnar hér fyrir ofan til að tengja á vefinn.