Læknablaðið

Volume

Læknablaðið - 15.08.1996, Page 46

Læknablaðið - 15.08.1996, Page 46
592 LÆKNABLAÐIÐ 1996; 82 Nýr doktor í læknisfræði Pann 25. mars síðastliðinn varði Emil L. Sig- urðsson heimilislæknir, doktorsritgerð við Gautaborgarháskóla. Ritgerðin nefnist Coron- ary Heart Disease among Iceiandic men. An epidemiological cohort study. Aðalleiðbein- andi Emils í doktorsnáminu var dr. Guðmund- ur Porgeirsson, yfirlæknir á Landspítalanum, en einnig naut Emil handleiðslu prófessors Calle Bengtsson við heimilislæknadeild Gauta- borgarháskóla. Fer ágrip doktorsritgerðarinn- ar hér á eftir: Coronary heart disease is the number one cause of death in industrialised countries, and in Iceland it accounts for about one-third of all deaths. The purpose of this thesis is to describe the epidemiological characteristics of various manifestations of coronary heart disease am- ong Icelandic men, with particular emphasis on the prevalence, risk factor profile and prognosis. The Reykjavik Study is a large population based cohort study starting in 1967. A total of 9139 men have participated at least once in the study. On the first visit to the Heart Preventive Clinic every participant was placed in one of the following diagnostic categories: 1. Recognised myocardial infarction. 2. Un- recognised myocardial infarction. 3. Angina pectoris with electrocardiographic changes of ischaemia. 4. Angina pectoris without el- ectrocardiographic changes. 5. Angina pector- is by Rose questionnaire only. 6. Participants with silent ST-T changes on electrocardio- gram. 7. Men with no manifestations of coron- ary heart disease. The prevalence of myocardial infarction increased during the study period. However, the prevalence of angina pectoris decreased, and this was of sufficient magnitude to offset the increase in the prevalence of myocardial infarction, leading to a significant fall in the Key words: Coronary heart disease, epidemiology, risk factors, prognosis, ECG changes, cardiomegaiy. prevalence of coronary heart disease (all forms combined). The prevalence of coronary heart disease was highly dependent on age. The risk factor profile and the survival probability var- ied considerably between the different cate- gories. Cardiovascular risk factors maintained their detrimental effects on prognosis in the presence of coronary heart disease. Thus, age, high serum cholesterol concentration, impair- ed glucose tolerance and smoking were found to be significant independent risk factors of coronary heart disease mortality among men with coronary heart disease. At least one-third of all myocardial infarctions among Icelandic men were unrecognised. The risk factor profile

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