Læknablaðið - 15.07.1999, Síða 21

LÆKNABLAÐIÐ 1999; 85
609
an hárri tíðni hjá öldruðum nú á seinustu ára-
tugum hennar.
Að þessum fæðingarárgöngum gengnum
fækkar sennilega ætisárum, einnig meðal aldr-
aðra. Þó ber að hafa í huga að nýir umhverfis-
þættir eru að koma fram sem kunna að breyta
þessari mynd og ber sérstaklega að nefna gigt-
arlyf og reykingar og óþekktir þættir geta hugs-
anlega breytt þessari spá (24-26).
Þakkir
Rannsóknin var styrkt af Vísindasjóði Land-
spítalans og Rannsóknarráði íslands.
HEIMILDIR
1. Warren JR, Marshall B. Unidentified curved bacilli on gast-
ric epithelium in active chronic gastritis. Lancet 1983; i:
1273-5.
2. Susser M, Stein Z. Civilisation and peptic ulcer. Lancet
1962; i: 115-9.
3. Sonnenberg A. Temporal trends and geographical variations
of peptic ulcer disease. Aliment Pharmacol Ther 1995;
9/Suppl. 2: 3-12.
4. Kurata JH, Corboy ED. Current peptic ulcer time trends. An
epidemiological profile. J Clin Gastroenterol 1988; 10:
259-68.
5. Sonnenberg A, Miiller H, Pace F. Birth-cohort analysis of
peptic ulcer mortality in Europe. J Chronic Dis 1985; 38:
309-17.
6. Katschinski BD, Logan RFA. Changes in birth-cohort pat-
tem of peptic ulcer mortality in England and Wales. Post-
grad Med J 1991; 67: 825-8.
7. Walt R, Katschinski B, Logan R, Ashley J, Langman M.
Rising frequency of ulcer perforation in elderly people in
The United Kingdom. Lancet 1986; i: 489-92.
8. Coggon D, Lambert P, Langman MJS. 20 years of hospital
admissions for peptic ulcer in England and Wales. Lancet
1981; i: 1302-4.
9. Svanes C, Lie RT, Kvále G, Svanes K, Söreide O. Incidence
of perforated ulcer in westem Norway 1935-1990: cohort or
period dependent time trends? Am J Epidemiol 1995; 141:
836-44.
10. Andersen IB, Bonnevie O, Jörgensen T, Sörensen TIA.
Time trends for peptic ulcer disease in Denmark, 1981-
1993. Analysis of hospitalization register and mortality
data. Scand J Gastroenterol 1998; 33: 260-6.
11. Tilvist RS, Vuoristo M, Varis K. Changed profile of peptic
ulcer disease in hospita! patients during 1969-1984 in
Finland. Scand J Gastroenterol 1987; 22: 1238-44.
12. Quartini A, Negri E, La Vecchia C. Trends in peptic ulcer
mortality in Italy, 1955-1985. J Epidemiol Community
Health 1992;46:494-7.
13. Gustavsson S, Kelly KA, Melton L, ZinsmeisterAR. Trends
in peptic ulcer surgery. A population-based study in
Rochester, Minnesota, 1956-1985. Gastroenterology 1988;
94: 688-94.
14. Gustavson S, Nyrén O. Time trends in peptic ulcer surgery,
1956 to 1986. A nation-wide survey in Sweden. Ann Surg
1989;210: 704-9.
15. Susser M. Period effects, generation effects and age effects
in peptic ulcer mortality. J Chronic Dis 1982; 35: 29-40.
16. Statistics and Epidemiology Research Corp. EGRET.
Seattle: Statistics and Epidemiology Research Corp. 1990.
17. Clayton D, Schifflers E. Models for temporal variation in
cancer rates. I: Age-period and age-cohort models. Stat
Med 1987;6:449-67.
18. Clayton D, Schifflers E. Models for temporal variation in
cancer rates. II: Age-period-cohort models. Stat Med 1987;
6: 469-81.
19. Svanes C, Salvesen H, Espehaug B. A multifactorial analy-
sis of factors related to lethality after treatment of perfora-
ted gastroduodenal ulcer 1935-1985. Ann Surg 1989; 209:
418-23.
20. Thors H, Sigurðsson H, Oddson E, Þjóðleifsson B. Aðgerð-
ir vegna sársjúkdóms í maga og skeifugöm. Læknablaðið
1994; 80: 179-84.
21. Hagskinna. Reykjavík: Hagstofa íslands 1997:90-1.
22. Friðriksson G. Saga Reykjavíkur. Bærinn vaknar. 1870-
1940. Reykjavík: Iðunn 1994.
23. Kristinsson K, Sigvaldadóttir E, Þjóðleifsson B. Algengi
mótefna gegn Helicobacter pylori á fslandi. Læknablaðið
1996; 82: 366-70.
24. Eiríksson K, Oddsdóttir M, Magnússon J. Rofsár á maga og
skeifugöm vegna sársjúkdóms. Sjúklingar á Landspítalan-
um 1989-1995. Læknablaðið 1998; 84: 466-73.
25. Svanes C, Soreide JA Skarstein A, Fevang BT, Bakke P,
Vollset SE, Svanes K, Söreide O. Smoking and ulcer per-
foration. Gut 1997; 41: 177-80.
26. Eastwood GL. Is smoking still important in the pathogene-
sis of peptic ulcer disease? J Clin Gastroenterrol 1997;
25/Suppl. 1: S1-S7.