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Læknablaðið - 01.07.2015, Síða 21

Læknablaðið - 01.07.2015, Síða 21
Y F i R l i T S G R E i n Önnur meðferð en lyfjameðferð Reykleysisráðgjöf og reykbindindi er það inngrip sem mestan þátt getur átt í að hægja á versnun lungnastarfsemi hjá sjúklingum með LLT. Ef vel er að slíku staðið má fá allt að 25% langtíma reykleys- isáhrif.54 Reykbindindi fækkar BVLLT og áhættuminnkunin er í beinu hlutfalli við lengd reykleysisins hjá LLT-sjúklingnum.55 Lungnaendurhæfing er mikilvæg fyrir alla sjúklinga með lang- vinna lungnateppu.2 Ekki hefur verið sýnt fram á að lungnaendur- hæfing fljótt eftir sjúkrahúslegu flýti fyrir bata eða fækki versn- unum.56 Þannig getur verið betra að láta nokkurn tíma líða áður en sjúklingur byrjar í lungnaendurhæfingu eftir sjúkrahúsinnlögn. Hins vegar hefur líkamsþjálfun í sjúkrahúslegu vegna BVLLT sýnt sig að flýta fyrir bata og lungnaendurhæfing eftir að sjúklingur hefur náð sér eftir bráða versnun fækkar sjúkrahúsinnlögnum og lækkar dánartíðni.2,57 Það er aukin dánartíðni við lækkaðan líkamsþyngdarstuðul og vannæring er mikilvægur áhættuþáttur fyrir slæmar horfur hjá LLT-sjúklingum.58,59 Eftirlit Rannsóknir hafa sýnt fram á að minni líkur eru á endurinnlögn ef sjúklingur hittir lækni innan 30 daga frá útskrift.60 Eftirlit hjúkr- unarfræðinga fljótt eftir útskrift getur einnig verið hjálplegt. Mis- vísandi niðurstöður hafa fengist við rannsóknir á sjálfshjálparúr- ræðum fyrir sjúklinga eftir útskrift og beðið er frekari rannsókna til að skera úr um virkni þeirra.2,3 Lokaorð Langvinn lungnateppa er algengur sjúkdómur með mikilli sjúkdómsbyrði og hárri dánartíðni. Þar skipta bráðar versnanir höfuðmáli. Markviss meðferð þeirra er mikilvæg og ekki er síður mikilvægt að reyna með öllum ráðum að fyrirbyggja endurteknar versnanir því þær skerða mjög lífsgæði sjúklinga og auka dánar- tíðni. Þessir sjúklingar koma víða við í heilbrigðisþjónustunni og því nauðsynlegt fyrir íslenska lækna að þekkja vel til þessa vanda- máls. Þá er rökvíst val sýklalyfja mikilvægt til að minnka líkur á sýklalyfjaónæmi með tilheyrandi þjáningum og kostnaði fyrir ís- lenska þjóð. Heimildir 1. Anzueto A, Sethi S, Martinez F. Exacerbations of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2007 4: 554–64. 2. GOLD (2015) Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. March. goldcopd.org – mars 2015. 3. Qureshi H, Sharafkhaneh A, Hanania NA. Chronic obst- ructive pulmonary disease exacerbations: latest evidence and clinical implications. Ther Adv Chronic Dis 2014 ;5: 212-27. 4. Donaldson G, Seemungal T, Bhowmik A, Wedzicha, J. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002; 57: 847-52. 5. Seemungal T, Donaldson G, Bhowmik A, Jeffries D, Wedzicha J. Time course and recovery of exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2000 161: 1608-13. 6. Seemungal T, Donaldson G, Paul E, Bestall J, Jeffries D, Wedzicha J. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998 151: 1418-22. 7. Vestbo, J, Lisa, D., Scanlon, P., Yates, J., Agusti, A., Bakke, P. et al. Changes in forced expiratory volume in 1 second overtime in COPD. N Engl J Med 2011; 365: 1184–1192. 8. Hurst J, Vestbo J. Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) investigators. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010; 363: 1128-38 9. Husebø GR, Bakke PS, Aanerud M, Hardie JA, Ueland T, Grønseth R, et al. Predictors of exacerbations in chronic obstructive pulmonary disease--results from the Bergen COPD cohort study. PLoS One 2014; 9: e109721. 10. Rennard SI, Locantore N, Delafont B, Tal-Singer R, Silverman EK, Vestbo J, et al. Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints. Identification of Five Chronic Obstructive Pulmonary Disease Subgroups with Different Prognoses in the ECLIPSE Cohort Using Cluster Analysis. Ann Am Thorac Soc 2015; 12: 303-12. 11. Beghé B, Verduri A, Roca M, Fabbri, L. Exacerbation of respiratory symptoms in COPD patients may not be exacerbations of COPD. Eur Respir J 2013; 41: 993-5. 12. Clini E, Beghé B, Fabbri L. Chronic obstructive pulmonary disease is just one component of the complex multimor- bidities in patients with COPD. Am J Respir Crit Care Med 2013; 187: 668-71. 13. Smith MC, Wrobel JP. Epidemiology and clinical impact of major comorbidities in patients with COPD.Int J Chron Obstruct Pulmon Dis 2014; 9: 871-88. 14. Sapey E, Stockley, R. COPD exacerbations.2: Aetiology. Thorax 2006; 61: 250-8. 15. Sethi S, Murphy T. Infection in the pathogenesis and course of chronic obstructive pulmonary disease. N Engl J Med 2008; 59: 2355-65. 16. Song Q, Christiani DC, XiaorongWang, Ren J. The global contribution of outdoor air pollution to the incidence, prevalence, mortality and hospital admission for chronic obstructive pulmonary disease: a systematic review and meta-analysis. Int J Environ Res Public Health 2014; 11: 11822-32. 17. Carlsen HK, Forsberg B, Meister K, Gíslason T, Oudin A. Ozone is associated with cardiopulmonary and stroke emergency hospital visits in Reykjavík, Iceland 2003-2009. Environ Health 2013; 12: 28. 18. Carlsen HK, Zoëga H, Valdimarsdóttir U, Gíslason T, Hrafnkelsson B. Hydrogen sulfide and particle matter levels associated with increased dispensing of anti-asthma drugs in Iceland's capital. Environ Res 2012; 113: 33-9. 19. Rizkallah J, Man S, Sin D. Prevalence of pulmonary embolism in acute exacerbations of COPD: a systematic review and metaanalysis. Chest 2009; 135: 786-93. 20. Yetgin GO, Aydin SA, Koksal O, Ozdemir F, Mert DK, Torun G. Clinical probability and risk analysis of patients with suspected pulmonary embolism. World J Emerg Med 2014; 5: 264-9. 21. Nishimura K, Nishimura T, Onishi K, Oga T, Hasegawa Y, Jones PW. Changes in plasma levels of B-type natriuretic peptide with acute exacerbations of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2014; 9: 155-62. 22. Price, L., Lowe, D., Hosker, H., Anstey, K., Pearson, M. and Roberts, C. UK National COPD Audit 2003: impact of hospital resources and organization of care on patient out- come following admission for acute COPD exacerbation. Thorax 2006; 61: 837-42. 23. Malolepszy, J, Boszormenyi N, Selroos O. Safety of form- oterol Turbuhaler at cumulative dose of 90 microg in patients with acute bronchialobstruction. Eur Respir J 2001; 18: 928-34. 24. Abroug F, Ouanes I, Abroug S, Dachraoui F, Abdallah SB, Hammouda Z, Ouanes-Besbes L. Systemic corticos- teroids in acute exacerbation of COPD: a meta-analysis of controlled studies with emphasis on ICU patients. Ann Intensive Care 2014; 4: 32. 25. De Coster DA, Jones M. Tailoring of corticosteroids in COPD management. Curr Respir Care Rep 2014; 3: 121-32. 26. Walters JA, Tan DJ, White CJ, Wood-Baker R. Different durations of corticosteroid therapy for exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev 2014; 12: CD006897. 27. Niewoehner D, Erbland M, Deupree R, Collins D, Gross N, Light R, et al. Effect of systemic glucocorticoids on exacerbations of chronic obstructive pulmonary disease. N Engl J Med 1999; 340: 1941-7. 28. 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Mas A, Masip J. Noninvasive ventilation in acute respira- tory failure. Int J Chron Obstruct Pulmon Dis 2014; 9: 837- 52. 38. Gudmundsson G, Gislason T, Janson C, Hallin R, Lindberg E, Suppli Ulrik C, et al. Risk factors for reho- spitalization in COPD: role of health status, anxiety and depression. Eur Resp J 2005; 26: 414-9. LÆKNAblaðið 2015/101 361

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