Læknablaðið - 01.12.1979, Page 23

LÆKNABLAÐIÐ
287
um sem aukaverkun eftir bólusetningu með
öðrum rauðu hunda bóluefnum en RA
27/3, þ.e. HPV-77DK12 og HPV-77DE5 og
Cendehill.1113 10,14 15 1718 Er þær stundum
nefnd „the arm syndrome11 og „the leg
syndrome" (eða „catcher’s crouch“). Ekki
hefur þeim verið lýst eftir notkun RA 27/3
og ekki fundust þessi einkenni í rannsókn-
inni hér í þetta sinn. Niðurstöður þessarar
rannsóknir okkar gefa því ekki tilefni til
að lækka bólusetningaraldur vegna auka-
verkana.
LOKAORÐ
Hér hefur verið skýrt frá bólusetningu
fyrsta hóps sem bólusettur er gegn rauðum
hundum í Reykjavík, og rannsókn á mót-
efnum og aukaverkunum, sem fylgdi í kjöl-
far bólusetningarinnar. Má telja árangur
hennar góðan, bæði hvað snertir svörun og
mótefnamyndun og hversu aukaverkanir
reyndust vægar. Hversu lengi mótefnin
haldast í verndandi magni geta aðeins end-
urteknar mótefnamælingar á þessum telp-
um leitt í ljós.
SUMMARY
This report describes rubella vaccination of
12 years old girls in Reykjavík 1977. No cases
of rubella were diagnosed serologically in Ice-
land from October 1975 until June 1978. Ice-
land can therefore be considered free from
rubella during the time of this study.
Originally 730 schoolgirls were tested for
rubella Hl-antibody. Of these 47.5% were sero-
positive (antibodytiter > 1/40), 1.6% had titer
1/20 and 50.9% were seronegative (titer rg
1/10 Of 384 negatives, 367 were vaccinated, 355
of whom with a titer g 1/10 (group A), and 12
with titer 1/20 (group B). 356 girls were bled
6 weeks after vaccination and 357 a year later.
One year after vaccination 94.49% had Hl-anti-
bodytiter ^ 1/40. Geometric mean titer in
group A was 62.07 6 weeks after vaccination
and 61.69 a year later whereas in group
B only 25% showed a significant rise in
titer. Geometric mean titer in group B was
lower, 40.0 6 weeks after vaccination and 25.20
one year later. This could indicate a past in-
fection and a poor response to revaccinatin.
Side reactions were found in 89 (24.3%) of the
vaccinees, 47 (12.8%) had arthralgia and 11
(3.0%) painfuily swollen joint. Not late coming
or long standing side reactions were found.
A follow-up on these groups in intended
during the next few years with special regard
to the current rubella epidemic beginning in
late summer 1978.
HEIMILDIR
1. Árnadóttir, Þ.: Mæling á mótefnum gegn
tveimur fósturskemmandi veirum, rubella-
veiru og cytomegaloveiru. B.Sc. ritgerð við
Háskóla Islands.
2. Balfour, H.H., Balfour, C.L., Eddmann, R.
K., Rierson, P.A.: Evaluation of Wistar RA
27/3 rubellavirus vaccine in children. Am.
J. Dis. Child. 130, 1089-1091, 1976.
3. Best, J.M., Banatvala, J.E., Bowen, J.M.:
New japanese rubeila vaccine: Compara-
tive trials Brit. Med. J. 3, 221-224, 1974.
4. Black, F.L., Lamm, S.H., Emmons, J.E.,
Pinheiro, F.P.: Reactions to rubella vaccine
and persistence of antibody in virgin-soil
population after vaccination and wild-viruse
induced immunization. J. of Inf. Dis. 133,
393-398, 1976.
5. Buser, F., Nicolas, A.: Vaccination with RA
27/3 rubella vaccine. Am. J. Dis. Chiid. 122,
53-56. 1971.
6. Böttinger, M., Heller, L., Rollof, S.I.:
rubella vaccination av tonarsflickor. Lákar-
tidn, 71, 1949-1951, 1974.
7. Carlsson, M.G., Johnsson, T., Renmarker,
K. : Rubella vaccination av várdspersonal.
Lákartidn, 71, 1955-1958, 1974.
8. Dudgeon, J.A., Marshall, W.C., Peckham,
C.S.: Rubella vaccine trials in aduits and
children. Am. J. Dis. Child. 118, 237-242,
1969.
9. Enell, J., Johnsson, T., Kullander, K.:
Rubella vaccination av skolflickor. Lákar-
tidn. 71, 1952-1955, 1974.
10. Freestone, D.S., Prydie, J., Hamilton Smith,
S.G., Laurence, G.: Vaccination of adults
with Wistar RA 27/3 rubella vaccine. J.
Hyg. Camb. 69, 471-477, 1971.
11. Gilmartin, R.C., Jabbour, J.T., Duenas, D.A.:
Rubelia vaccine myeloradiculoneuritis. Jour.
Ped. 80, 406-412, 1972.
12. Grillner, L., Hedström, C.E., Bergström, H„
Forssman, L„ Rigner, A„ Lycke, E.: Vacci-
ation against rubella of newly delivered
women. Scand. J. Inf. Dis. 5, 237-241, 1973.
13. Kilroy, A.W., Schaffner, W„ Fleet, W.F.,
Lefkowitz, L.B., Karzon, D.T., Fenichel,
G.M.: Two syndromes following rubella
immunization. Jama 214: 2287-2292, 1970.
14. Spruance, S.L., Smith, C.B.: Joint compli-
cations associated with derivatives of HPV-
77 rubella virus vaccine. Am J. Dis. Child.
122, 105-111, 1971.
15. Spruance, S.L., Kloch, L.E., Bailey, A„
Ward, J.R., Smith, C.B.: Recurred joint
symptoms in children vaccinated with HPV-
77DK 12 rubella vaccine. J. Pediatrics. 80,
413-417, 1972.
16. Spruance, S.L., Metcalf, R„ Smith, C.B.,
Griffiths, M.M., Ward, J.R.: Chronic arthro
pathy associated with rubella vaccination.
Arthritis and Rheumatism. 20, 741-747, 1977.
17. Thompson, G.R., Ferreyra, A., Brackett,
R.G.: Acute arthritis complicating rubella