Læknablaðið - 15.11.1994, Side 27

LÆKNABLAÐIÐ 1994; 80
463
ekki sjálfstæðir þættir hvað varðar horfur þá er
meira um mislitna æxli í þeim vefjagerðum sem
hafa verri horfur og einnig er S-fasinn þar
hærri. Sums staðar eru niðurstöður úr flæði-
greiningu notaðar til að ákvarða meðferð. Á
grundvelli þeirra niðurstaðna sem fengust í
þessari rannsókn er varla hægt að búast við að
flæðigreining verði ákvarðandi þáttur um með-
ferð hjá sjúklingum með skjaldkirtilskrabba-
mein hér á landi.
Þakkir
Sigrún Kristjánsdóttir meinatæknir fær sér-
stakar þakkir fyrir undirbúning sýna og einnig
Guðríður Ólafsdóttir fyrir tölvuvinnu. Einnig
fá Helgi Sigvaldason verkfræðingur þakkir
fyrir tölfræðiaðstoð og Þorgeir Þorgeirsson
meinafræðingur þakkir fyrir aðgang að vefja-
sýnunt.
Rannsóknarsjóður Krabbameinsfélags ís-
lands og Vísindasjóður styrktu þessa rann-
sókn.
HEIMILDIR
1. Tulinius H, Storm HH, Pukkala E, Anderson A, Er-
icsson J. Cancer in the Nordic Countries, 1981-86. A
Joint Publication of the Five Nordic Cancer Registries.
APMIS 1992; 100/Suppl. 31: 106-7.
2. Hrafnkelsson J, Jónasson JG, Sigurdsson G, Sigvalda-
son H. Tulinius H. Thyroid cancer in Iceland 1955-1984.
Acta Endocrinol 1988; 118: 566-72.
3. Sigurdsson H, Baldetorp B. Borg Á, Dalberg M, Fernö
M, Killander D, et al. Indicators of prognosis in node
negative breast cancer. N Engl J Med 1990; 322: 1045-
53.
4. Kallioniemi OP, Punnonen R, Mattila J, Lettinen M.
Koivula T. Prognostic significance of DNA index, mul-
tiploidy and S-phase fraction in ovarian cancer. Cancer
1988; 61: 334-9.
5. Pasieka JL, Zedenius J, Auer G, Grimelius L, Höög A,
Lundell G, et al. Addition of nuclear DNA content to
the AMES risk-group classification for papillary thyroid
cancer. Surgery 1992; 112: 1154-60.
6. Camargo RS, Scafuri AG, Castro de Tolosa EM, Ferrei-
ra EAB. DN A image cytometric analysis of differentiat-
ed thyroid adenocarcinoma specimens. Am J Surg 1992;
164: 640-5.
7. Tulinius H, Sigvaldason H. Aldursstöðlun. Læknablað-
ið 1987; 64: 133-6.
8. UICC, TNM Classification of Malignant Tumours. Ge-
neva: International Union Against Cancer, 1987.
9. Hedinger C, Sobin LH. Histological typing of thyroid
tumours. International histological classification of tu-
mours, no 11. Geneva: World Health Organization,
1974.
10. Hedley DW, Friedlander ML, Taylor IW. Rugg CA,
Musgrove EA. Method for analysis of cellular DNA
content of paraffin-embedded pathological material us-
ing flow cytometry. J Histochem Cytochem 1983; 31:
1333-5.
11. Thornthwaite JT, Sugarbaker EV, Temple WJ. Prep-
aration of tissues for DNA flow cytrometric analysis.
Cytometry 1980; 1: 229-37.
12. Stál O, Klintenberg C, Franzén G, Risenberg B, Ar-
vidsson S, Bjelkenkrantz K. A comparison of static fluo-
rometry and flow cytometry for the estimation of ploidy
and DNA replication in human breast cancer. Breast
Cancer Res Treat 1986; 7: 15-22.
13. Kaplan EL, Meier P. Non-parametric estimation from
incomplete observations. J Am Stat Assoc 1958; 53:
457-81.
14. Cox DR. Regression models and life tables. J R Stat Soc
1972; 34: 187-220.
15. Muir C, Waterhouse J, Mack T, Powell J, Whelan S.
Cancer incidence in five continents 1987; Vol V, IARC
Scientific Publication 88. Lyon: International Agency
for Research on Cancer, 1987.
16. Prentice RL, Kato H, Yoshiomoto K, Mason M. Radi-
ation exposure and thyroid cancer incidence among Hi-
rosima and Nagasaki residents. Nat Cancer Inst Monogr
1982; 62: 207-12.
17. Hrafnkelsson J, Sveinsson ÞE, Sigvaldason H, Tulinius
H. Krabbameinsáhætta hjá börnum sem fengu geisla-
meðferð vegna góðkynja sjúkdóma fyrir 1950. Lækna-
blaðið 1990; 76: 131-6.
18. Hrafnkelsson J, Tulinius H, Jonasson JG, Ólafsdóttir G,
Sigvaldason H. Papillary thyroid carcinoma in Iceland.
A study of the occurrence in families and the coexistence
of other primary tumours. Acta Oncologica 1989; 28:
785-8.
19. Dos Santos Silva I, Swerdlow AJ. Thyroid cancer epide-
miology in England and Wales: time trends and ge-
ographical distribution. Br J Cancer 1993; 67: 330^10.
20. Akslen LA, Nilssen S, Kvále G. Reproductive factors
and risk of thyroid cancer. A prospective study of 63.090
women from Norway. Br J Cancer 1992; 65: 772—4.
21. Glattre E, Akslen LA. Thoresen SÖ, Haldoren T. Ge-
ographic patterns and trends in the incidence of thyroid
cancer in Norway 1970-1986. Cancer Detection and Pre-
vention 1990; 14: 621-31.
22. Ennow KR, Magnusson SM. Natural radiation in Ice-
land and the Faraoe Islands (Ritgerð (reprint)). Brpn-
shpj: Statens Institut for Strálehygiejne, 1982.
23. Nikitorov Y, Gnepp DR. Pediatric thyroid cancer after
the Chernobyl disaster: Pathomorphological study of 84
cases from the Republic of Belarus. In: Programs and
Abstracts of the 83rd Annual meeting of the United
States and Canadian Academy of Pathology, March 12-
18, 1994, San Francisco, California. Abstract nr. 306
24. Petterson B, Adami HO, Wilander E, Coleman MP.
Trends in thyroid cancer incidence in Sweden, 1958-
1981, by histopathologic type. Int J Cancer 1991; 48:
28-33.
25. Nishiyama RH, Dunn EL, Thompson NW. Anaplastic
spindle-cell and giant-cell tumors of the thyroid gland.
Cancer 1972; 30: 113-27.
26. Joensuu H, Klemi P, Eerola E. Tuominen J. Influence
of cellular DNA content on survival in differentiated
thyroid cancer. Cancer 1986; 58: 2462-7.
27. GrantCS, HaylD, RyanJJ, Bergsthralh EJ, Rainwater
LM, Goellner JR. Diagnostic and prognostic utility of
flow cytometric DNA measurements in follicular thy-
roid tumors. World J Surg 1990; 14: 283-90.
28. Tallroth-Ekman E, Wallin G, Backdal M, Löwhagen T,
Auer G. Nuclear DNA content in anaplastic giant cell
thyroid carcinoma. Am J Clin Oncol (CCT) 1989 b; 12:
442-6.
29. Hrafnkelsson J, Stál O, Eneström S, Jónasson JG,
Björnsson J, Ólafsdóttir K, et al. Cellular DNA pattern,
S-phase frequency and survival in papillary thyroid can-
cer. Acta Oncologica 1988; 27: 329-33.