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Læknablaðið - 15.02.1994, Blaðsíða 20

Læknablaðið - 15.02.1994, Blaðsíða 20
62 LÆKNABLAÐIÐ by further increasing the dose. A non-significant tendency to more numerous and more severe side- effects was observed at the higher doses of H. In addition, higher H doses were associated with significant increases in serum creatinine, uric acid and glucose. Little is gained by increasing the dose of enalapril and hydrochlorothiazide above 10 mg and 12.5 mg. Higher doses are associated with elevated cost, metabolic disturbances and probably more numerous side-effects. HEIMILDIR 1. Lessem JN, Rucinka E, Vickers FF, Espie J, Sromovsky JA. Long-term enalapril - a new converting enzyme inhibitor - in the treatment of mild to moderate essential hypertension. Results of a worldwide multiclinic study. Clin Exp Hypertens (A) 1985; 7: 1515-39. 2. Sassano P, Chatellier G, Billaud E, Alhenc Gelas F, Corvol P, Mendard J. Treatment of mild to moderate hypertension with or without the converting enzyme inhibitor enalapril as the first step. A six-month double-blind trial. Am J Med 1987; 83: 227-35. 3. Sassano P, Chatellier G, Billaud E, Corvol P, Ménard J. Comparison of increase in the enalapril dose and addition of hydrochlorothiazide as second-step treatment of hypertensive patients not controlled by enalapril alone. J Cardiovasc Pharmacol 1989; 13: 314-9. 4. Vaisse B, Souchet T, Delage Y, Poggi L. Étude comparative de l’énalapril, de l’hydrochlorothiazide et de leur association dans le traitement de l’HTA essentielle. Ann Cardiol Angéiol 1991; 40: 51-4. 5. Jones DW, Sands CD. Treatment of essential hypertension in Asians: Enalapril as monotherapy versus combination therapy with hydrochlorothiazide. Pharmacotherapy 1991; 11: 127-30. 6. The Enalapril-Hydrochlorothiazide in Essential Hypertension Canadian Working Group. Enalapril and enalapril-hydrochlorothiazide in the treatment of essential hypertension. Clin Ther 1993; 15: 364-73. 7. Helgeland A, Hagelund CH, Strömmen R, Tretli S. Enalapril, atenolol and hydrochlorothiazide in mild to moderate hypertension. Lancet 1986; i: 872-5. 8. Dahlöf B, Hansson L, Acosta JH, et al. Controlled trial of enalapril and hydrochlorothiazide in 200 hypertensive patients. Am J Hypertens 1988; 1: 38- 41. 9. Magee PFA, Freis ED. Is low-dose hydrochlorothiazide effective. Hypertension 1986; Suppl. II: 135-9. 10. Strocchi E, Bossini A, Ranieri G, Filitti V. Efficacy and tolerability of enalapril (20 mg) / hydrochlorothiazide (12.5 mg) combination therapy in essential hypertension. Clin Ther 1991; 13: 737-46. 11. Prince MJ, Stuart CA, Padia M, Bandi Z, Holland OB. Metabolic effects of hydrochlorothiazide and enalapril during treatment of the hypertensive diabetic patient. Enalapril for hypertensive diabetics. Arch Intem Med 1988; 148: 2363-8. 12. Parving HH. Anderson AR, Smidt UM, et al. Early aggressive antihypertensive treatment reduces rate of decline in kidney function in diabetic nephropathy. Lancet 1985; i: 1175-9. 13. Dahlöf B, Hansson L. Regression of left ventricular hypertrophy in previously untreated essential hypertension: Different effects of enalapril and hydrochlorothiazide. J Hypertens 1992; 10: 1513-24. 14. Consensus Trial Study Group. Effects of enalapril on mortality in severe congestive heart failure. Results of the Cooperative North Scandinavian Enalapril Survival Study (Consensus). N Engl J Med 1987; 316: 1429-35.

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