Læknablaðið - 15.02.1994, Qupperneq 20
62
LÆKNABLAÐIÐ
by further increasing the dose. A non-significant
tendency to more numerous and more severe side-
effects was observed at the higher doses of H.
In addition, higher H doses were associated with
significant increases in serum creatinine, uric acid
and glucose.
Little is gained by increasing the dose of enalapril
and hydrochlorothiazide above 10 mg and 12.5
mg. Higher doses are associated with elevated
cost, metabolic disturbances and probably more
numerous side-effects.
HEIMILDIR
1. Lessem JN, Rucinka E, Vickers FF, Espie J,
Sromovsky JA. Long-term enalapril - a new
converting enzyme inhibitor - in the treatment of
mild to moderate essential hypertension. Results of
a worldwide multiclinic study. Clin Exp Hypertens
(A) 1985; 7: 1515-39.
2. Sassano P, Chatellier G, Billaud E, Alhenc Gelas F,
Corvol P, Mendard J. Treatment of mild to moderate
hypertension with or without the converting enzyme
inhibitor enalapril as the first step. A six-month
double-blind trial. Am J Med 1987; 83: 227-35.
3. Sassano P, Chatellier G, Billaud E, Corvol P, Ménard
J. Comparison of increase in the enalapril dose
and addition of hydrochlorothiazide as second-step
treatment of hypertensive patients not controlled by
enalapril alone. J Cardiovasc Pharmacol 1989; 13:
314-9.
4. Vaisse B, Souchet T, Delage Y, Poggi L. Étude
comparative de l’énalapril, de l’hydrochlorothiazide
et de leur association dans le traitement de l’HTA
essentielle. Ann Cardiol Angéiol 1991; 40: 51-4.
5. Jones DW, Sands CD. Treatment of essential
hypertension in Asians: Enalapril as monotherapy
versus combination therapy with hydrochlorothiazide.
Pharmacotherapy 1991; 11: 127-30.
6. The Enalapril-Hydrochlorothiazide in Essential
Hypertension Canadian Working Group. Enalapril
and enalapril-hydrochlorothiazide in the treatment of
essential hypertension. Clin Ther 1993; 15: 364-73.
7. Helgeland A, Hagelund CH, Strömmen R, Tretli S.
Enalapril, atenolol and hydrochlorothiazide in mild to
moderate hypertension. Lancet 1986; i: 872-5.
8. Dahlöf B, Hansson L, Acosta JH, et al. Controlled
trial of enalapril and hydrochlorothiazide in 200
hypertensive patients. Am J Hypertens 1988; 1: 38-
41.
9. Magee PFA, Freis ED. Is low-dose
hydrochlorothiazide effective. Hypertension 1986;
Suppl. II: 135-9.
10. Strocchi E, Bossini A, Ranieri G, Filitti V.
Efficacy and tolerability of enalapril (20 mg) /
hydrochlorothiazide (12.5 mg) combination therapy
in essential hypertension. Clin Ther 1991; 13: 737-46.
11. Prince MJ, Stuart CA, Padia M, Bandi Z, Holland
OB. Metabolic effects of hydrochlorothiazide and
enalapril during treatment of the hypertensive diabetic
patient. Enalapril for hypertensive diabetics. Arch
Intem Med 1988; 148: 2363-8.
12. Parving HH. Anderson AR, Smidt UM, et al. Early
aggressive antihypertensive treatment reduces rate of
decline in kidney function in diabetic nephropathy.
Lancet 1985; i: 1175-9.
13. Dahlöf B, Hansson L. Regression of left ventricular
hypertrophy in previously untreated essential
hypertension: Different effects of enalapril and
hydrochlorothiazide. J Hypertens 1992; 10: 1513-24.
14. Consensus Trial Study Group. Effects of enalapril on
mortality in severe congestive heart failure. Results
of the Cooperative North Scandinavian Enalapril
Survival Study (Consensus). N Engl J Med 1987;
316: 1429-35.