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Læknablaðið - 15.06.2011, Qupperneq 21

Læknablaðið - 15.06.2011, Qupperneq 21
Y F I R L I T á unga aldri, ef margir æðagúlar eru til staðar eða ef fleiri f fjölskyldunni eru með sjúkdóminn. Hafa verður í huga að regluleg skimun getur ekki komið í veg fyrir allar blæðingar þar sem æðagúlar geta myndast og rofnað á skemmri tíma en fimm árum.'H Skimun ættingja Almennt er ekki mælt með skimun ef eingöngu einn ættingi í fyrsta ættlið hefur fengið SIB (það þyrfti að skima yfir 300 einstaklinga til að koma í veg fyrir eitt dauðsfall).1 Undantekningar eru gerðar ef systkini þess sem blætt hefur er undir 40 ára aidri eða ef nákominn ættingi hefur miklar áhyggjur af því að hann hafi æðagúl. Skimun er réttlætanleg hjá einstaklingi ef tveir eða fleiri ættingjar í fyrsta ættlið hafa fengið SIB og einnig í fjölskyldum þar sem blöðrunýmasjúkdómur er ættgengur.1 Skimun ætti að íhuga hjá eineggja tvíbura ef hinn hefur orðið fyrir SIB. Órofinn æðagúll fundinn óvænt Ef æðagúll finnst fyrir tilviljun við myndrannsókn sem fram- kvæmd er af öðrum ástæðum þarf að meta hvort betra sé að fylgjast með æðagúlnum með reglulegum myndatökum eða framkvæma aðgerð. Við áhættumat þarf að taka tillit til aldurs (yngra fólk á fleiri ár fram undan), einnig þarf að hafa í huga að hætta á rofi eykst með aldrinum.45 Önnur atriði sem þarf að vega og meta eru: stærð æðagúls (aukin hætta er á rofi með aukinni stærð), staðsetning (aukin hætta á rofi ef gúll- inn er í aftari heilablóðveitunni), form gúlsins, kyn (konur eru í aukinni hættu), aðrir sjúkdómar og fjölskyldusaga. Þar sem ákvarðanatakan getur verið flókin er nauðsynlegt að hafa samráð við taugaskurðlækni í þessum efnum. Höfundar þakka Aroni Björnssyni heila- og taugaskurðlækni kærlega fyrir yfirlestur greinarinnar og gagnlegar ábendingar. Heimildir 1. van Gijn J, Kerr RS, Rinkel GJE. Subarachnoid haemorrhage. Lancet 2007; 369: 306-18. 2. Linn FHH, Rinkel GJE, Algra A, van Gijn J. Incidence of subarachnoid hemorrhage: role of region, year, and rate of computed tomography: a meta-analysis. Stroke 1996; 27: 625-9. 3. Anderson C, Anderson N, Bonita R, et al. Epidemiology of aneurysmal subarachnoid hemorrhage in Australia and New Zealand: incidence and case fatality from the Australasian Cooperative Research on Subarachnoid Hemorrhage Study (ACROSS). Stroke 2000; 31:1843-50. 4. Brisman L, Song, J, Newell DW. Cerebral Aneurysms. N Engl J Med 2006; 355:928-39. 5. Rinkel GJE, Djibuti M, Algra A, van Gijn J. Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 1998; 29:251-6. 6. White PM, Wardlaw JM. Unruptured intracranial aneurysms. J Neuroradiol. 2003; 30: 336-50. 7. Schievink WI. Intracranial aneurysms. N Engl J Med 1997; 336:28-40. 8. Feigin VL, Rinkel GJE, Lawes CM, et al. Risk factors for subarachnoid hemorrhage: an updated systematic review of epidemiological studies. Stroke 2005; 36:2773-80. 9. Ruigrok YM, Buskens E, Rinkel GJE. Attributable risk of common and rare determinants of subarachnoid hemorrhage. Stroke 2001; 32:1173-5. 10. Wang MC, Rubinstein D, Kindt GW, et al. Prevalence of intracranial aneurysms in first-degree relatives of patients with aneurysms. Neurosurg Focus 2000; 13:1-5. 11. Fann JR, Kukull WA, Katon WJ, Longstreth WT. Physical activity and subarachnoid haemorrhage: a population based case-control study. J Neurol Neurosurg Psychiatry 2000; 69: 768-72. 12. Anderson C, Ni Mhurchu C, Scott D, Bennett D, Jamrozik K, Hankey G. Triggers of subarachnoid hemorrhage: role of physical exertion, smoking, and alcohol in the Australasian Cooperative Research on Subarachnoid Hemorrhage Study (ACROSS). Stroke 2003; 34:1771-6. 13. Intemational Study of Unruptured Intracranial Aneurysms Investigators. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 2003; 362: 103-10. 14. Wijdicks EFM, Schievink WI. Perimesencephalic nonan- eurysmal subarachnoid hemorrhage: first hint of a cause?. Neurology 1997; 49:634-6. 15. Schwartz TH, Solomon RA. Perimesencephalic nonaneurysmal subarachnoid hemorrhage: review of the literature. Neurosurgery 1996; 39:433-40. 16. Rinkel GJE, Wijdicks EFM, Vermeulen M, Tans JTJ, Hasan D, van Gijn J. Acute hydrocephalus in nonaneurysmal perimesencephalic hemorrhage: evidence of CSF block at the tentorial hiatus. Neurology 1992; 42:1805-7. 17. Schwartz TH, Farkas J. Quadrigeminal non-aneurys- mal subarachnoid hemorrhage: a tme variant of perimesencephalic subarachnoid hemorrhage: case report. Clin Neurol Neurosurg 2003; 105:95-8. 18. Brilstra EH, Rinkel GJE, Algra A, van Gijn J. Rebleeding, secondary ischemia, and timing of operation in patients with subarachnoid hemorrhage. Neurology 2000; 55:1656- 60. 19. Caeiro L, Menger C, Ferro JM, Albuquerque R, Figueira ML. Delirium in acute subarachnoid haemorrhage. Cerebrovasc Dis 2005; 19: 31-8. 20. Pinto AN, Canhao P, Ferro JM. Seizures at the onset of subarachnoid haemorrhage. J Neurol 1996; 243:161-4. 21. Cloft HJ, Joseph GJ, Dion JE. Risk of cerebral angiography in patients with subarachnoid hemorrhage, cerebral aneurysm, and arteriovenous malformation: a meta- analysis. Stroke 1999; 30:317-20. 22. Vieco PT, Shuman WP, Alsofrom GF, Gross CE. Detection of circle of Willis aneurysms in patients with acute subarachnoid hemorrhage: a comparison of CT angiography and digital subtraction angiography. AJR Am J Roentgenol 1995; 165:425-30. 23. Huston J 3rd, Nichols DA, Luetmer PH, et al. Blinded prospective evaluation of sensitivity of MR angiography to known intracranial aneurysms: importance ofaneurysm size. AJNR Am J Neuroradiol 1994; 15:1607-14. 24. Roos YBWEM, de Haan RJ, Beenen LFM, Groen RJM, Albrecht KW, Vermeulen M. Complications and outcome in patients with aneurysmal subarachnoid haemorrhage: a prospective hospital based cohort study in The Netherlands. J Neurol Neurosurg Psychiatry 2000; 68:337- 41. 25. Ohkuma H, Tsurutani H, Suzuki S. Incidence and significance of early aneurysmal rebleeding before neurosurgical or neurological management. Stroke 2001; 32:1176-80. 26. Molyneux AJ, Kerr RS, Yu LM, et al. Intemational subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005; 366: 809-17. 27. Suarez JI, Tarr RW, Selman WR. Aneurysmal subarachnoid hemorrhage. N Engl J Med 2006; 354: 387-96. 28. Rabinstein AA, Weigand S, Atkinson JL, Wijdicks EFM. Pattems of cerebral infarction in aneurysmal subarachnoid hemorrhage. Stroke 2005; 36:992-7. 29. Hijdra A, van Gijn J, Stefanko S, van Dongen KJ, Vermeulen M, van Crevel H. Delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: clinicoanatomic correlations. Neurology 1986; 36:329-33. 30. Hop JW, Rinkel GJE, Algra A, van Gijn J. Initial loss of consciousness and risk of delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage. Stroke 1999; 30: 2268-71. 31. Lysakowski C, Walder B, Costanza MC, Tramér MR. Transcranial Doppler versus angiography in patients with vasospasm due to a ruptured cerebral aneurysm: a systematic review. Stroke 2001; 32:2292-8. 32. Phan TG, Huston J, Campeau NG, Wijdicks EFM, Atkinson JL, Fulgham JR. Value of diffusion-weighted imaging in patients with a nonlocalizing examination and vasospasm from subarachnoid hemorrhage. Cerebrovasc Dis 2003; 15:177-81. 33. Pickard JD, Murray GD, Illingworth R, et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. BMJ 1989; 298: 636-42. 34. Van den Bergh WM on behalf of the MASH study group. Magnesium sulfate in aneurysmal subarachnoid hemorrhage: a randomized controlled trial. Stroke 2005; 36:1011-5. 35. Rinkel GJE, Feigin VL, Algra A, van Gijn J. Circulatory volume expansion therapy for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev 2004; 4: CD000483. 36. Lozier AP, Sciacca RR, Romagnoli MF, Connolly ES. Ventriculostomy-related infections: a critical review of the literature. Neurosurgery 2002; 51:170-81. 37. Huang J, Van Gelder JM. The probability of sudden death from rupture of intracranial aneurysms: a meta-analysis. Neurosurgery 2002; 51:1101-5. 38. Stegmayr B, Eriksson M, Asplund K. Declining mortality from subarachnoid hemorrhage: changes in incidence and case fatality from 1985 through 2000. Stroke 2004; 35:2059- 63. 39) Buczacki SJ, Kirkpatrick PJ, Seeley HM, Hutchinson PJ. Late epilepsy following open surgery for aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psyc- hiatry 2004; 75:1620-2. 40. Hackett ML, Anderson CS for the ACROSS Group. Health outcomes 1 year after subarachnoid hemorrhage: an intemational population-based study. Neurology 2000; 55: 658-62. 41. Mayer SA, Kreiter KT, Copeland D, et al. Global and domain-specific cognitive impairment and outcome after subarachnoid hemorrhage. Neurology 2002; 59:1750-8. 42. Powell J, Kitchen N, Heslin J, Greenwood R. Psychosocial outcomes at three and nine months after good neurological recovery from aneurysmal subarachnoid haemorrhage: predictors and prognosis. J Neurol Neurosurg Psychiatry 2002; 72: 772-81. 43. Powell J, Kitchen N, Heslin J, Greenwood R. Psychosocial outcomes at 18 months after good neurological recovery from aneurysmal subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 2004; 75:1119-24. 44. Wermer MJH, Kool H, Albrecht KW, Rinkel GJE. Aneurysm Screening after Treatment for Ruptured Aneurysms Study Group. Subarachnoid hemorrhage treated with clipping: long-term effects on employment, relationships, personality, and mood. Neurosurgery 2007; 60:91-8. 45. Schievink WI, Limburg M, Dreissen JJ, Peeters FL, ter Berg HW. Screening for unruptured familial intracranial aneurysms: subarachnoid hemorrhage 2 years after angio- graphy negative for aneurysms. Neurosurgery 1991; 29: 434-7. LÆKNAblaðið 2011/97 361

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