Læknablaðið - 15.12.1991, Blaðsíða 13

LÆKNABLAÐIÐ
377
SUMMARY
A study was conducted by comparing the
results from 5568 patients from the years
1987 and 1990, which had Chlamydia culture
and Chlamydiazyme@-tests done at the same
time, to assess the feasibility of using different
breakpoints in the Chlamydiazyme®-test for
males and females, or reporting out grey-zones.
Confirmatory tests were done on 247 positive
specimens and calculations were done to assess
the feasibility of doing confirmatory tests on
samples with high but negative values. If the
breakpoint can be lowered by 40 to 50% to 0.060
without significantly decreasing the specificity,
the sensitivity in males will increase to 84% from
just over 70%. Based on this, a decision has been
reached to do confirmatory tests on all specimens
with Chlamydiazyme-values 0.060 or higher.
Results with values above the official cutoff will
be reported as positive if the confirmatory test is
positive. Negative results with values above 0.060
will be reported as suspicious if the Confirmatory
test is positive.
HEIMILDIR
1. Steingrímsson Ó, Þórarinsson H, Sigfúsdóttir A,
Kolbeinsson A. Könnun á tíðni sýkinga af völdum
C. trachomatis á íslandi í samanburði við tíðni
lekanda. Rannsóknir á sjúklingum er leituðu til
húð- og kynsjúkdómadeildar Heilsuvemdarstöðvar
Reykjavíkur árið 1982. Læknablaðið 1983: 69: 289-
93.
2. Magnusson SS, Sveinsson B, Oskarsson Th, Geirsson
RT, Steingrímsson Ó. A microbiological study
of sexually transmitted disease in women with
salpingitis. Am J Obst Gynecol 1986; 155: 602.
3. Steingrímsson Ó, Jónsson Ó. Tíðni sýkinga af
völdum ChUimydia trachomatis í Sauðárkrókshéraði.
Læknablaðið 1986; 72: 164-6.
4. Guðmundsson S, Geirsson RT, Steingrímsson Ó.
Klamydíu- og lekandasýkingar á fyrri helmingi
meðgöngu. Læknablaðið 1987; 73: 121-5.
5. Heilbrigðisskýrslur 1984-1985. Reykjavík:
Landlæknisembættið, 1989.
6. Óskarsson T, Steingrímsson Ó, Geirsson RT,
Thórarinsson H. The Prevalence of Lower Genital
Tract Infection with Neisseria gonorrhoeae and
Chlamydia trachomatis in Women requesting induced
Abortion and in their Sexual Partners. Acta Obstet
Gynecol Scand 1990; 69: 635-40.
7. Schacter J. Chlamydial infections. N Engl J Med
1978; 298: 428-35, 490-5, 540-9.
8. Tómasson J. Betur má ef duga skal. Fréttabréf lækna
1990; 8(3): 2.
9. Ryan RW, Kwasnik I, Steingrímsson Ó,
Gudmundsson J, Thorarinsson H, Tilton RC. Rapid
Detection of Chlamydia trachomatis by an Enzyme
Immunoassay Method. Diagn Microbiol Infect Dis
1986; 5: 225.
10. Guðmundsson J, Ryan RW, Þórarinsson H, Tilton
RC, Magnússon SS, Kwasnik I, Steingrímsson Ó.
Greining klamydíusýkinga með ensímmótefnaaðferð
(Chlamydiazyme). Læknablaðið 1986; 72: 157-63.
11. Moncada J, Schachter J, Bolan G, et al. Confirmatory
Assay Increases Specificity of the Chlamydiazyme
Test for Chlamydia trachomatis Infection of the
Cervix. J Clin Microbio! 1990; 28: 1770-3.
12. Hrafn Tulinius. Faraldsfræði og heilsuvemd.
Reykjavík: Háskólaútgáfan, 1989.
13. Nettleman MD, Jones RB. Cost-effectiveness of
screening Women at Moderate Risk for Genital
Infections Caused by Chlamydia trachomatis. JAMA
1988; 260: 207-13.
14. Schwebke JR, Stamm WE, Handslield HH. Use
of Sequential Enzyme Immunoassay and Direct
Fluorescent Antibody Tests for Detection of
Chlamydia trachomatis Infections in Women. J Clin
Microbiol 1990; 28: 2473-6.