Læknablaðið

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Læknablaðið - 15.09.1996, Page 9

Læknablaðið - 15.09.1996, Page 9
LÆKNABLAÐIÐ 1996; 82 621 Mismikil beinþynning í lendhrygg og lærleggshálsi Gunnar Sigurðsson, Díana Óskarsdóttir Sigurðsson G, Óskarsdóttir D Lumbar vertebral and femoral neck bone densito- metry; site of bone density measurement may affect therapy decision Læknablaðið 1996; 82: 621-6 Objective: The aim of this study was to compare the results provided by the measurement of vertebral bodies (L:II-IV) and femoral neck bone mineral density (BMD) by dual energy X-ray absorptio- metry (DEXA) for assessing the individual risk of osteoporosis. Material and methods: Three-hundred-thirty-one Icelandic women aged 35-65 years who attended the Reykjavik City Hospital Bone Densitometry during the period, lst of October 1994 — 31st of December 1995, participated in the study. Women who had received hormone replacement therapy or were re- ceiving drugs or had a disease known to affect bone metabolism were excluded. Criteria suggested by WHO were used to categorize women as “at risk” for osteoporosis, bone density >1 standard devia- tion below the young adult mean (35-40 years in our case) or as “low risk”, bone density above this level. Results: When lumbar vertebral body BMD was used as the primary risk indicator, 18.7% of the women classified as low risk would be at risk if femoral neck BMD was added. Similarly when fem- oral neck BMD was used as a prime indicator 7.5% of the women classified as low risk would be at risk if lumbar BMD was added. Frá lyflækningadeild Sjúkrahúss Reykjavíkur. Fyrirspurnir, bréfaskriftir: Gunnar Sigurðsson, lyflækningadeild Sjúkra- húss Reykjavíkur, 108 Reykjavík. Conclusion: These results suggest that both lumbar vertebral and femoral neck measurements should be made when assessing the risk in this age group as an aid in deciding preventive therapy. Ágrip Tilgangur: Beinmagnsmælingar í lendliðbol- um og lærleggshálsi hafa reynst hafa verulegt forspárgildi um beinbrot á þessum stöðum. Til- gangur þessarar rannsóknar var að kanna hversu vel mæling á öðrum staðnum segði til um beinmagn á hinum staðnum í áhættuhópi íslenskra kvenna. Efniviður og aðgerðir: Beinmagn („bone mineral density“, g/sm2) var mælt á Borgar- spítalanum með dual energy absorptiometry (DEXA) í lendliðbolum (L:II-L:IV) og lær- leggshálsi íslenskra kvenna (n=331) á aldrin- um 35-65 ára. Konur sem tekið höfðu tíða- hvarfahormón voru útilokaðar. Omarkvísi mælingaraðferða var 1,0-1,6%. Niðurstöður: Fylgnistuðull (r) milli mæli- staða reyndist 0,72. Ef stuðst var við skilgrein- ingu Alþjóða heilbrigðisstofnunarinnar á ónógu beinmagni (osteopenia), sem eitt stað- alfrávik neðan meðaltals ungra kvenna, van- mat mæling á lendhrygg ónógt beinmagn í lær- leggshálsi í 18,7% tilfella. Ef mælt var ein- göngu í lærleggshálsi vanmat sú mæling 7,5% kvenna sem voru neðan þessara marka í mæl- ingu á lendliðbolum. Ef notuð voru skilmerki beinþynningar (osteoporosis) sem 2,5 staðal- frávik neðan meðaltals ungra kvenna voru samsvarandi tölur 4,8% og 3,6%. Ályktun: Þessar niðurstöður benda til að æskilegt sé að mæla beinmagn bæði í lendhrygg

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