Læknablaðið - 15.05.2008, Blaðsíða 22
FRÆÐIGREINAR______
BANDVEFSSJÚKDÓMAR
Þakkir
Þessi grein er yfirlit yfir niðurstöður sem
aflast hafa í samstarfi við Alfreð Árnason,
Árna Jón Geirsson, Ásbjöm Sigfússont, Ástráð
B. Hreiðarsson, Hallgrím Guðjónsson, Helga
Valdimarsson, Kristján Erlendsson, Kristján
Steinsson, Ragnhildi Kolka og Þóru Víkingsdóttur,
auk nokkurra erlendra samstarfsmanna (sjá heim-
ildir). Öllu þessu ágæta fólki færi ég mínar bestu
þakkir fyrir gott samstarf.
Heimildir
1. Arason GJ. Magnakerfið. Læknaneminn 2008; xx:x-x
2. Lachmann PJ, Walport, MJ. Deficiency of the effector
mechanisms of the immune response and autoimmunity.
Ciba Found Symp.1987; 129:149-71.
3. Naama JK, Niven IP, Zoma A, Mitchell WS, Whaley K.
Complement, antigen-antibody complexes and immune
complex disease. J Clin Lab Immunol 1985; 17: 59-67.
4. Sullivan KE. Complement deficiency and autoimmunity.
Curr Opin Pediatr 1998; 10: 600-6.
5. Pickering MC, Walport MJ. Links between complement
abnormalities and systemic lupus erythematosus.
Rheumatology 2000; 39:133-41.
6. Traustadóttir KH, Rafnar BO, Steinsson K, Valdimarsson H,
Erlendsson K. Participation of factor B in residual immune
complex red cell binding activity observed in serum from
a C2-deficient systemic lupus erythematosus patient may
delay the appearance of clinical symptoms. Arthritis Rheum
1998; 41: 427-34.
7. Blanchong CA, Zhou B, Rupert KL, et al. Deficiencies
of human complement component C4A and C4B and
heterozygosity in length variants of RP-C4-CYP21-TNX
(RCCX) modules in caucasians. The load of RCCX genetic
diversity on major histocompatibility complex-associated
disease. J Exp Med 2000; 191: 2183-96.
8. Steinsson K, Ámason A, Erlendsson K, et al. A study of the
major histocompatibility complex in a Caucasian family with
multiple cases of systemic lupus erythematosus: association
with the C4AQ0 phenotype. Rheumatol 1995; 22:1862-6.
9. Steinsson K, Jónsdóttir S, Arason GJ, et al. A study of the
association of HLA DR, DQ, and complement C4 alleles with
systemic lupus erythematosus in Iceland. Ann Rheum Dis.
1998; 57: 503-5.
10. Schifferli JA, Steiger G, Paccaud JP, Sjoholm AG, Hauptmann
G. Difference in the biological properties of the two forms of
the fourth component of human complement (C4). Clin Exp
Immunol 1986; 63: 473-7.
11. Arason GJ, D'Ambrogio MS, Víkingsdóttir Þ, Sigfússon Á,
Valdimarsson H. Enzyme immunoassays for measuring
complement-dependent prevention of immune precipitation
(PIP) and solubilization of preformed antigen-antibody
complexes (SOL). J Immunol Methods 1999; 223: 37-46.
12. Arason GJ, Steinsson K, Kolka R, Víkingsdóttir Þ,
D'Ambrogio MS, Valdimarsson H. Patients with systemic
lupus ery thematosus are defective in complement-dependent
prevention of immune precipitation. Rheumatology 2004; 43:
783-9.
13. Arason GJ, Geirsson ÁJ, Kolka R, Víkingsdóttir Þ,
Valdimarsson H. Deficiency of complement-dependent
prevention of immune precipitation in systemic sclerosis.
Ann Rheum Dis 2002; 61: 257-60.
14. Arason GJ, Kolka R, Hreiðarsson ÁB, et al. Defective
prevention of immune precipitation in autoimmune diseases
is independent of C4*AQ0. Clin Exp Immunol 2005; 140:572-
9.
15. Arason GJ, Kolka R, Nilsson-Ekdahl K, Nilsson B, Steinsson
K, Rönnelid J. Enhanced immune complex precipitation in
SLE is mediated by antibodies to Clq. Immunobiology 2005;
210: 488.
16. Walport MJ. Complement and systemic lupus erythematosus.
Arthritis Res 2002;4 Suppl 3:S279-93.
17. Stefánsson Thors V, Kolka R, Sigurðardóttir SL, Eðvardsson
VO, Arason G, Haraldsson X. Increased frequency of
C4B*Q0 alleles in patients with Henoch-Schönlein purpura.
Scand J Immunol 2005; 61: 274-8.
18. McLean RH, Wyatt RJ, Julian BA. Complement phenotypes
in glomerulonephritis: increased frequency of homozygous
null C4 phenotypes in IgA nephropathy and Henoch-
Schönlein purpura. Kidney Int 1984; 26: 855-60.
19. Sævarsdóttir S, Steinsson K, Lúðvíksson BR, Gröndal G,
Valdimarsson H. Mannan-binding lectin may facilitate the
clearance of circulating immune complexes—implications
from a study on C2-deficient individuals. Clin Exp Immunol
2007; 148: 248-53.
20. Traustadóttir KH, Sigfússon Á, Steinsson K, Erlendsson K.
C4A deficiency and elevated level of immune complexes:
the mechanism behind increased susceptibility to systemic
lupus erythematosus. J Rheumatol 2002; 29: 2359-66.
21. Kristjánsdóttir H, Bjarnadóttir K, Hjálmarsdóttir IB, Gröndal
G, Ámason A, Steinsson K. A study of C4AQ0 and MHC
haplotypes in Icelandic multicase families with systemic
lupus erythematosus. J Rheumatol 2000; 27: 2590-6.
22. Traustadóttir KH, Steinsson K, Erlendsson K. C4AQ0
superimposed on a primary defect increases the susceptibility
to systemic lupus erythematosus (SLE) in a family with
association between C4AQ0 and SLE. J Rheumatol 1998; 25:
2118-25.
23. Steinsson K, Amason A, Erlendsson K, et al. A study of the
major histocompatibility complex in a Caucasian family with
multiple cases of systemic lupus erythematosus: association
with the C4AQ0 phenotype. J Rheumatol 1995; 22:1862-6.
24. Manderson AP, Botto M, Walport MJ. The role of complement
in the development of systemic lupus erythematosus. Annu
Rev Immunol 2004; 22: 431-56.
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