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Læknablaðið - 15.05.2008, Qupperneq 22

Læknablaðið - 15.05.2008, Qupperneq 22
FRÆÐIGREINAR______ BANDVEFSSJÚKDÓMAR Þakkir Þessi grein er yfirlit yfir niðurstöður sem aflast hafa í samstarfi við Alfreð Árnason, Árna Jón Geirsson, Ásbjöm Sigfússont, Ástráð B. Hreiðarsson, Hallgrím Guðjónsson, Helga Valdimarsson, Kristján Erlendsson, Kristján Steinsson, Ragnhildi Kolka og Þóru Víkingsdóttur, auk nokkurra erlendra samstarfsmanna (sjá heim- ildir). Öllu þessu ágæta fólki færi ég mínar bestu þakkir fyrir gott samstarf. Heimildir 1. Arason GJ. Magnakerfið. Læknaneminn 2008; xx:x-x 2. Lachmann PJ, Walport, MJ. Deficiency of the effector mechanisms of the immune response and autoimmunity. Ciba Found Symp.1987; 129:149-71. 3. Naama JK, Niven IP, Zoma A, Mitchell WS, Whaley K. Complement, antigen-antibody complexes and immune complex disease. J Clin Lab Immunol 1985; 17: 59-67. 4. Sullivan KE. Complement deficiency and autoimmunity. Curr Opin Pediatr 1998; 10: 600-6. 5. Pickering MC, Walport MJ. Links between complement abnormalities and systemic lupus erythematosus. Rheumatology 2000; 39:133-41. 6. Traustadóttir KH, Rafnar BO, Steinsson K, Valdimarsson H, Erlendsson K. Participation of factor B in residual immune complex red cell binding activity observed in serum from a C2-deficient systemic lupus erythematosus patient may delay the appearance of clinical symptoms. Arthritis Rheum 1998; 41: 427-34. 7. Blanchong CA, Zhou B, Rupert KL, et al. Deficiencies of human complement component C4A and C4B and heterozygosity in length variants of RP-C4-CYP21-TNX (RCCX) modules in caucasians. The load of RCCX genetic diversity on major histocompatibility complex-associated disease. J Exp Med 2000; 191: 2183-96. 8. Steinsson K, Ámason A, Erlendsson K, et al. A study of the major histocompatibility complex in a Caucasian family with multiple cases of systemic lupus erythematosus: association with the C4AQ0 phenotype. Rheumatol 1995; 22:1862-6. 9. Steinsson K, Jónsdóttir S, Arason GJ, et al. A study of the association of HLA DR, DQ, and complement C4 alleles with systemic lupus erythematosus in Iceland. Ann Rheum Dis. 1998; 57: 503-5. 10. Schifferli JA, Steiger G, Paccaud JP, Sjoholm AG, Hauptmann G. Difference in the biological properties of the two forms of the fourth component of human complement (C4). Clin Exp Immunol 1986; 63: 473-7. 11. Arason GJ, D'Ambrogio MS, Víkingsdóttir Þ, Sigfússon Á, Valdimarsson H. Enzyme immunoassays for measuring complement-dependent prevention of immune precipitation (PIP) and solubilization of preformed antigen-antibody complexes (SOL). J Immunol Methods 1999; 223: 37-46. 12. Arason GJ, Steinsson K, Kolka R, Víkingsdóttir Þ, D'Ambrogio MS, Valdimarsson H. Patients with systemic lupus ery thematosus are defective in complement-dependent prevention of immune precipitation. Rheumatology 2004; 43: 783-9. 13. Arason GJ, Geirsson ÁJ, Kolka R, Víkingsdóttir Þ, Valdimarsson H. Deficiency of complement-dependent prevention of immune precipitation in systemic sclerosis. Ann Rheum Dis 2002; 61: 257-60. 14. Arason GJ, Kolka R, Hreiðarsson ÁB, et al. Defective prevention of immune precipitation in autoimmune diseases is independent of C4*AQ0. Clin Exp Immunol 2005; 140:572- 9. 15. Arason GJ, Kolka R, Nilsson-Ekdahl K, Nilsson B, Steinsson K, Rönnelid J. Enhanced immune complex precipitation in SLE is mediated by antibodies to Clq. Immunobiology 2005; 210: 488. 16. Walport MJ. Complement and systemic lupus erythematosus. Arthritis Res 2002;4 Suppl 3:S279-93. 17. Stefánsson Thors V, Kolka R, Sigurðardóttir SL, Eðvardsson VO, Arason G, Haraldsson X. Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura. Scand J Immunol 2005; 61: 274-8. 18. McLean RH, Wyatt RJ, Julian BA. Complement phenotypes in glomerulonephritis: increased frequency of homozygous null C4 phenotypes in IgA nephropathy and Henoch- Schönlein purpura. Kidney Int 1984; 26: 855-60. 19. Sævarsdóttir S, Steinsson K, Lúðvíksson BR, Gröndal G, Valdimarsson H. Mannan-binding lectin may facilitate the clearance of circulating immune complexes—implications from a study on C2-deficient individuals. Clin Exp Immunol 2007; 148: 248-53. 20. Traustadóttir KH, Sigfússon Á, Steinsson K, Erlendsson K. C4A deficiency and elevated level of immune complexes: the mechanism behind increased susceptibility to systemic lupus erythematosus. J Rheumatol 2002; 29: 2359-66. 21. Kristjánsdóttir H, Bjarnadóttir K, Hjálmarsdóttir IB, Gröndal G, Ámason A, Steinsson K. A study of C4AQ0 and MHC haplotypes in Icelandic multicase families with systemic lupus erythematosus. J Rheumatol 2000; 27: 2590-6. 22. Traustadóttir KH, Steinsson K, Erlendsson K. C4AQ0 superimposed on a primary defect increases the susceptibility to systemic lupus erythematosus (SLE) in a family with association between C4AQ0 and SLE. J Rheumatol 1998; 25: 2118-25. 23. Steinsson K, Amason A, Erlendsson K, et al. A study of the major histocompatibility complex in a Caucasian family with multiple cases of systemic lupus erythematosus: association with the C4AQ0 phenotype. J Rheumatol 1995; 22:1862-6. 24. Manderson AP, Botto M, Walport MJ. The role of complement in the development of systemic lupus erythematosus. Annu Rev Immunol 2004; 22: 431-56. 374 LÆKNAblaðið 2007/93
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