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Læknablaðið - 15.06.2012, Blaðsíða 22

Læknablaðið - 15.06.2012, Blaðsíða 22
RANNSÓKN Heimildir 1. Cohen AT, Agnelli G, Anderson FA, Arcelus JI, Bergqvist D, Brecht JG, et al. Venous thromboembolism (VTE) in Europe. The number of VTE events and associated morbi- dity and mortality. Thromb Haemost 2007; 98: 756-64. 2. Eurostat statistics on health and safety. epp.eurostat.eu/ portal/page/portal/eurostat/home. desember 2009. 3. Alikhan R, Peters F, Wilmott R, Cohen AT. Fatal pulmon- ary embolism in hospitalised patients: a necropsy review. J Clin Pathol 2004; 57:1 254-7. 4. Sandler DA, Martin JF. Autopsy proven pulmonary embolism in hospital patients: are we detecting enough deep vein thrombosis? J R Soc Med 1989; 82: 203-5. 5. Prevention of fatal postoperative pulmonary embolism by low doses of heparin. An international multicentre trial. Lancet 1975; 2:45-51. 6. Anderson FA Jr, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med 1991; 151:933- 8. 7. Geerts WH, Bergqvist D, Pineo GF, Heit JA, Samama CM, Lassen MR, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 381S-453S. 8. Amin A, Stemkowski S, Lin J, Yang G. Thromboprophylaxis rates in US medical centers: success or failure? J Thromb Haemost 2007; 5:1610-6. 9. Piazza G, Seddighzadeh A, Goldhaber SZ. Double trouble for 2,609 hospitalized medical patients who developed deep vein thrombosis: prophylaxis omitted more often and pulmonary embolism more frequent. Chest 2007; 132: 554-61. 10. Cohen AT, Tapson VF, Bergmann JF, Goldhaber SZ, Kakkar AK, Deslandes B, et al. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet 2008; 371:387-94. 11. Gangireddy C, Rectenwald JR, Upchurch GR, Wakefield TW, Khuri S, Henderson WG, et al. Risk factors and clinical impact of postoperative symptomatic venous thromboembolism. J Vasc Surg 2007; 45:335-41; discussion 41-2. 12. Leizorovicz A, Cohen AT, Turpie AGG, Olsson C-G, Vaitkus PT, Goldhaber SZ, et al. Randomized, Placebo- Controlled Trial of Dalteparin for the Prevention of Venous Thromboembolism in Acutely 111 Medical Patients. Circulation 2004; 110: 874-9. 13. Samama MM, Cohen AT, Darmon JY, Desjardins L, Eldor A, Janbon C, et al. A comparison of enoxaparin with placebo for the prevention of venous thromboembolism in acutely ill medical patients. Prophylaxis in Medical Patients with Enoxaparin Study Group. N Engl J Med 1999; 341: 793-800. 14. Collins R, Scrimgeour A, Yusuf S, Peto R. Reduction in Fatal Pulmonary Embolism and Venous Thrombosis by Perioperative Administration of Subcutaneous Heparin. N Engl J Med 1988; 318:1162-73. 15. Kakkar AK, Cimminiello C, Goldhaber SZ, Parakh R, Wang C, Bergmann J-F. Low-Molecular-Weight Heparin and Mortality in Acutely 111 Medical Patients. N Engl J Med 2011; 365: 2463-72. 16. Prandoni P, Lensing AW, Cogo A, Cuppini S, Villalta S, Carta M, et al. The long-term clinical course of acute deep venous thrombosis. Ann Intem Med 1996; 125:1 -7. 17. Karlsson G, Riba P, Thoroddsson I, Gudbjomsson B. Segamyndun í djúpum bláæðum ganglima. Uppgjör frá FSA 1975-1990. Læknablaðið 2000; 86:19-24. 18. Sjálander A, Jansson JH, Bergqvist D, Eriksson H, Carlberg B, Svensson P. Efficacy and safety of anticoagulant prophylaxis to prevent venous thromboembolism in acutely ill medical inpatients: a meta-analysis. J Int Med 2008; 263: 52-60. 19. Maynard G, Stein J. Designing and implementing effective venous thromboembolism prevention protocols: lessons from collaborative efforts. J Thromb Thrombolys 2010; 29: 159-66. 20. Preventing Hospital-Acquired Venous Thromboembolism A Guide for Effective Quality Improvement. Society of Hospital medicine. hospitalmedicine.org/AM/ Template.cfm?Section=Quality_Improvement_Resource_ Rooms&Template=/CM/ContentDisplay.cfm&Conten- tID=6092. - ágúst 2010. 21. Bullock-Palmer RP, Weiss S, Hyman C. Innovative app- roaches to increase deep vein thrombosis prophylaxis rate resulting in a decrease in hospital-acquired deep vein thrombosis at a tertiary-care teaching hospital. J Hosp Med 2008; 3:148-55. ENGLISH SUMMARY Evaluation of thromboprophylactic therapy at Landspítali - The National University Hospital of lceland; a cross-sectional study on acute wards Kristjánsdottir HL1, Gudnadottir GS', Fjalldal SB', Thorarinsdottir HR2, Bjarnason A', Einarsson O' Objective: Venous thromboembolic disease is a serious and often fatal complication following hospital admission. Studies show that thrombop- rophylactic therapy for this condition is often underutilized. The aim of this study was to evaluate the performance of thromboprophylactic the- rapy at Landspítali - The University Hospital of lceland in adult patients admitted to acute wards. Methods and materials: On 2 December 2009 hospital charts of admitted patients on acute wards were reviewed and assessed for app- ropriatethromboprophylactic treatment according to the 2008 guidelines from The American College of Chest Physicians. The results were compared to those of other countries from the multinational Endorse study from 2008. Results: 251. patient were included of whom 47% were considered at risk for venous thromboembolic disease. Of those 57% received app- ropriate thromboprophylactic treatment or 78% of surgical and 26% of medical patients. Conclusions: Adherence to clinical guidelines for thromboprophylactic treatment at surgical wards of Landspítali - The National University Hospital of lceland was good and well above the average compared to the results of the Endorse study. Performance on the medical wards was on the other hand below average. Our results show that application of thromoboprophylactic treatment at Landspítali could be improved and thereby enhance patient safety. Key words: prophylactic treatment, venous thromboembolism, hospitalized patients. Correspondence: Hallgerður Lind Kristjánsdóttir hallgerdur.lind@gmail.com Departments of ’Medicine and 2Anasthesia and Intensive Care, Landspítali-University Hospital. 346 LÆKNAblaðið 2012/98
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