Læknablaðið - 01.05.2022, Blaðsíða 23

L ÆKNABL AÐIÐ 2022/108 243
R A N N S Ó K N
Heimildir
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E N G L I S H S U M M A R Y
Ellen A. Tryggvadóttir1
Þórhallur I. Halldórsson1
Bryndís E. Birgisdóttir1
Laufey Hrólfsdóttir1,2
Rikard Landberg3
Ingibjörg Th. Hreiðarsdóttir4,5
Hildur Harðardóttir5,6
Ingibjörg Gunnarsdóttir1,7
1Unit for Nutrition Research, Landspitali University Hospital and Faculty
of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland,
2Institution of Health Science Research, University of Akureyri and Akureyri
Hospital, 3Division of Food and Nutrition Science, Chalmers University of
Technology, Gothenburg-Sweden, 4Department of Obstetrics and Gynecology,
Landspitali University Hospital, Reykjavík, Iceland, 5Faculty of Medicine,
University of Iceland Reykjavík, Iceland, 6Livio Reykjavík, Reproductive Center
in Reykjavík, Iceland 7Landspitali University hospital; Nutrition Department.
Correspondence: Ellen Alma Tryggvadóttir, eat2@hi.is,
Key words: Pregnancy, diet, fatty acids, biomarker, supplements.
Correlation between intake of fish or supplements containing omega-3 fatty acids
and early pregnancy plasma concentrations.
INTRODUCTION: Long-chain polyunsaturated omega-3 fatty acids are considered
important for fetal development, but previous studies suggest suboptimal intake in
part of pregnant women in Iceland. The study aim was to evaluate intake of food and
supplements containing omega-3 fatty acids, among pregnant women in Iceland and
correlations to fatty acid composition in plasma.
MATERIALS AND METHODS: Subjects were 853 pregnant women attending their
11-14 weeks ultrasound appointment. Information on intake of food and supplements
containing long-chain omega-3 fatty acids (eicosapentaenoic acid (EPA) and
docosahexaenoic acid (DHA)) as well as background was obtained by a questionnaire.
Blood samples were collected for analysis of plasma fatty acids. Correlation was
evaluated using the Spearman correlation.
RESULTS: Median intake of lean fish was 1.3 times per week, while fatty fish was
consumed once monthly. About 50% of the women took omega-3 containing supplements
daily. Higher intake of both fish and omega-3 containing supplements was reflected in
higher omega-3 plasma levels (r=0.37 p<0.001). A positive correlation was seen between
intake of cod liver oil/capsules (r=0.23, p=0.001), omega-3 oil/capsules (r=0.20, p=0.001)
and plasma concentration of omega-3. However, no correlation was seen between intake
of a maternal multivitamin containing omega-3 and corresponding plasma concentration
(r=0.03, p=0.98).
CONCLUSION: Intake of food and supplements containing omega-3 fatty acids was
reflected in plasma concentration, except for an Icelandic maternal multivitamin. One
third of the women followed the recommendation of eating fish at least twice weekly.
About 50% had a daily intake of supplements containing omega-3 fatty acids.
doi 10.17992/lbl.2022.05.691