Læknablaðið - 15.08.1990, Side 40

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LÆKNABLAÐIÐ
these studies have been carried out on middle aged
men. The results, however, have been interpreted
as being also pertinent for women. The aim of
this study was to investigate blood lipids as risk
factors for CHD in women as studied both cross-
sectionally and longitudinally.
The population sample studied initially 1968-69
comprised 1462 women living in Göteborg at that
time (participation rate 90.1%). They were selected
according to certain age strata and predetermined
birthdates divisible by six. The women were
restudied six and 12 years later. In the cross-
sectional study of myocardial infarction in woraen,
women in the population study were used as a
control group and compared with all women who
survived MI in Göteborg during the period 1968-
70. The longitudinal follow-up is still going on,
especially regarding causes of death. 24- year
follow-up is planned for 1992-93.
Studied cross-sectionally, there was a significant
over- representation of women with M1 who had
triglyceride values above the median values of
the population sample. The cholesterol values of
women with MI, however, were no higher than
in the general population of women. Studied
longitudinally it was found that women who
had initial triglyceride values >2.2 mmol/1 had
significantly increased risk for MI, stroke and death
of all causes. In women with initial cholesterol
levels > 8.0 mmol/1 only a trend for MI was seen.
This, however, was not confirmed in multivariate
analysis for cholesterol, but was still strongly
positive for triglycerides after taking cholesterol
into account as a confounding factor. The waste to
hip ratio greater than 0.8 was also shown to be an
independend risk factor for CHD in women.
We conclude that elevation of serum triglycerides
is the main lipid risk factor for CHD in women,
and that elevated serum cholesterol is of minor
importance.
HEIMILDIR
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