Læknablaðið - 15.08.1990, Blaðsíða 45

LÆKNABLAÐIÐ
311
lower concentration levels, but -4.3% bias at
10.4 mmol/1 when animal sera were analysed.
HDL cholesterol measurements show an average
total imprecision of 16.0% and a large negative
bias when animal serum was used. Average total
imprecision for triglyceride measurements at three
different concentration levels was 12.2%, which
is almost twice as high as that for cholesterol.
This survey indicates that there is scope for
reducing interlaboratory differences, by improving
the calibration of both the cholesterol and the
triglyceride methods and by improving the HDL
separation technique.
ÞAKKIR
Höfundar vilja þakka dr. Torsten Aronsson,
sérfræðingi við Centrallaboratoriet á
Akademiska Sjukhuset, Uppsölum fyrir veitta
aðstoð við tölfræðiútreikninga. Þátttakendum í
könnuninni er öllum þakkað samstarfið en þeir
eru auk rannsóknastofu Landspítalans: Alda
Ingvarsdóttir, rannsóknastofu Læknasetursins,
Reykjavík, Eyjólfur Harðarson, rannsóknastofu
Sjúkrahúss Akraness, Hafdís Bjamadóttir,
rannsóknastofu Sjúkrahúss Suðurlands,
Selfossi, Kristinn Sigurjónsson,
rannsóknastofu Landakotsspítala, Leifur
Franzson, rannsóknastofu Borgarspítala,
Vigfús Þorsteinsson og Valgerður Franklín,
rannsóknastofu Fjórðungssjúkrahússins
á Akureyri og Þorsteinn Þorsteinsson,
rannsóknastofu Hjartavemdar.
HEIMILDIR
1. Stamler J, Wentworth D, Neaton JD. Is the
relationship between serum cholesterol and risk
of premature death from coronary heart disease
continuous and graded? Findings in 356 222 primary
screenees of the multiple risk factor intervention trial
(MRFIT). JAMA 1986; 256: 2823-8.
2. Oliver MF. Hypercholesterolemia and coronary heart
disease: an answer. Br Med J 1984; 288: 423-4.
3. NIH Consensus Development Conference Statement:
Lowering blood cholesterol to prevent heart disease.
JAMA 1985; 253: 2080-6.
4. The Study Group of European Atherosclerosis
Society: Strategies for the prevention of coronary
heart disease: a policy statement of the European
Atherosclerosis Society. Eur Heart J 1987: 8: 77-88.
5. Information frán Socialstyrelsens lakemedelsavdelning
1988; 5: 152-65.
6. Aronsson T, Bjömstad P, Leskinen E. Uldall A. de
Verdier C-H. Ássessment of analytical quality in
Nordic clinical chemistry laboratories using data from
contemporary national programs. Scand J Clin Lab
Invest 1984; 172: 115-24.
7. Bachorik PS, Most B. Lippel K et al. Plasma
lipoprotein analysis: Relative precision ot' total
cholesterol and lipoprotein cholesterol measurements
in twelve lipid research clinics laboratories. Clin
Chem 1981; 27: 1217-22.
8. McMillan TA. Wamick GR. Interlaboratory
proficiency survey of cholesterol and high-density
lipoprotein cholesterol measurement. Clin Chem
1988; 34: 1629-32.
9. Naito HK. The need for accurate total cholesterol
measurement: Recommended analytical goals.
current state of reliability. and guidelines for better
determinations. Clin Lab Med Í989: 9: 37-60.
10. Friedewald WT. Levy RI and Fredrickson DS.
Estimation of the concentration of low-density
lipoprotein cholesterol in plasnta. without use of the
preparative ultracentrifuge. Clin Chem 1972: 18: 499-
502.