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Læknablaðið - 15.08.1990, Qupperneq 45

Læknablaðið - 15.08.1990, Qupperneq 45
LÆKNABLAÐIÐ 311 lower concentration levels, but -4.3% bias at 10.4 mmol/1 when animal sera were analysed. HDL cholesterol measurements show an average total imprecision of 16.0% and a large negative bias when animal serum was used. Average total imprecision for triglyceride measurements at three different concentration levels was 12.2%, which is almost twice as high as that for cholesterol. This survey indicates that there is scope for reducing interlaboratory differences, by improving the calibration of both the cholesterol and the triglyceride methods and by improving the HDL separation technique. ÞAKKIR Höfundar vilja þakka dr. Torsten Aronsson, sérfræðingi við Centrallaboratoriet á Akademiska Sjukhuset, Uppsölum fyrir veitta aðstoð við tölfræðiútreikninga. Þátttakendum í könnuninni er öllum þakkað samstarfið en þeir eru auk rannsóknastofu Landspítalans: Alda Ingvarsdóttir, rannsóknastofu Læknasetursins, Reykjavík, Eyjólfur Harðarson, rannsóknastofu Sjúkrahúss Akraness, Hafdís Bjamadóttir, rannsóknastofu Sjúkrahúss Suðurlands, Selfossi, Kristinn Sigurjónsson, rannsóknastofu Landakotsspítala, Leifur Franzson, rannsóknastofu Borgarspítala, Vigfús Þorsteinsson og Valgerður Franklín, rannsóknastofu Fjórðungssjúkrahússins á Akureyri og Þorsteinn Þorsteinsson, rannsóknastofu Hjartavemdar. HEIMILDIR 1. Stamler J, Wentworth D, Neaton JD. Is the relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356 222 primary screenees of the multiple risk factor intervention trial (MRFIT). JAMA 1986; 256: 2823-8. 2. Oliver MF. Hypercholesterolemia and coronary heart disease: an answer. Br Med J 1984; 288: 423-4. 3. NIH Consensus Development Conference Statement: Lowering blood cholesterol to prevent heart disease. JAMA 1985; 253: 2080-6. 4. The Study Group of European Atherosclerosis Society: Strategies for the prevention of coronary heart disease: a policy statement of the European Atherosclerosis Society. Eur Heart J 1987: 8: 77-88. 5. Information frán Socialstyrelsens lakemedelsavdelning 1988; 5: 152-65. 6. Aronsson T, Bjömstad P, Leskinen E. Uldall A. de Verdier C-H. Ássessment of analytical quality in Nordic clinical chemistry laboratories using data from contemporary national programs. Scand J Clin Lab Invest 1984; 172: 115-24. 7. Bachorik PS, Most B. Lippel K et al. Plasma lipoprotein analysis: Relative precision ot' total cholesterol and lipoprotein cholesterol measurements in twelve lipid research clinics laboratories. Clin Chem 1981; 27: 1217-22. 8. McMillan TA. Wamick GR. Interlaboratory proficiency survey of cholesterol and high-density lipoprotein cholesterol measurement. Clin Chem 1988; 34: 1629-32. 9. Naito HK. The need for accurate total cholesterol measurement: Recommended analytical goals. current state of reliability. and guidelines for better determinations. Clin Lab Med Í989: 9: 37-60. 10. Friedewald WT. Levy RI and Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasnta. without use of the preparative ultracentrifuge. Clin Chem 1972: 18: 499- 502.

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