Læknablaðið - 15.10.1990, Blaðsíða 13

LÆKNABLAÐIÐ
383
spectrum of target cells in the CNS in both
infections is apparently similar. As there is
increasing evidence that the nervous system is
one of the primary target organs of infection
with HIV, visna of sheep offers a promising
possibility as a model for trials aimed at
preventing or treating AIDS.
ÞAKKIR
Það yrði of langt mál að geta allra sem
lagt hafa hönd á plóg á ýmsum stigum
þessarar vinnu, en þó skal þökkuð sérstaklega
tæknileg aðstoð Elsu Benediktsdóttur,
Eyglóar Gísladóttur, Roger Lutley, Steinunnar
Amadóttur og Svövu Högnadóttur, ennfremur
þökkum við Margréti Kristinsdóttur fyrir
frágang handrits. Jafnframt skal Dr. V.V.
Joshi þakkað fyrir efnivið úr lungnabólgu
í eyðni og Dr. H. Budka og Dr. Kára
Stefánssyni fyrir efnivið úr heilabólgu í eyðni.
HEIMILDIR
1. Sigurdsson B. Observations on three slow infections
of sheep. Br Vet J 1954; 110: 255-70.
2. Sigurdsson B. Thormar H. Pálsson PA. Cultivation
of visna virus in tissue culture. Arch Ges Virusforsch
1960; 10: 368-81.
3. Pálsson PA. Maedi and visna in sheep. In: Kimberlin
RH, ed. Slow Virus Diseases of Animals and Man.
Amsterdam: North-Holland, 1976: 17-43.
4. Georgsson G, Martin JR, Klein J, Pálsson PA,
Nathanson N, Pétursson G. Primary demyelination
in visna: An ultrastructural study of Icelandic sheep
with clinical signs following experimental infection.
Acta Neuropathol 1982; 57: 171-8.
5. Gonda MA. Wong-Staal F, Gallo RC, Clements JE,
Narayan O, Gilden RV. Sequence homology and
morphologic similarity of HTLV-III and visna virus, a
pathogenic lentivirus. Science 1985; 227: 170-3.
6. Sonigo P, Alizon M, Staskus K, Klatzmann D,
Cole S, Danos O, Retzel E. Tiollais P, Haase A.
Wain-Hobson S. Nucleotide sequence of the visna
lentivirus: Relationship to the AIDS virus. Cell 1985;
42: 369-82.
7. Braun MJ, Clements JE, Gonda MA. The visna virus
genome: Evidence for a hypervariable site in the
env gene and sequence homology among lentivirus
envelope proteins. J Virol 1987; 61: 4046-54.
8. Thormar H. Visna-maedi infection in cell cultures and
in laboratory animals. In: Kimberlin RH, ed. Slow
Virus Diseases of Animals and Man. Amsterdam:
North-Holland; 1976: 97-114.
9. Popovic M, Samgadharan MG, Read E, Gallo RC.
Detection, isolation and continuous production of
cytopathic retroviruses (HTLV-III) from patients with
AIDS and pre-AIDS. Science 1984; 224: 497-500.
10. Sigurdardóttir B, Thormar H. Isolation of a viral
agent from the lungs of sheep affected with maedi.
J Infect Dis 1964; 114: 55-60.
11. Gudnadóttir M, Pálsson PA. Successful transmission
of visna by intrapulmonary inoculation. J Infect Dis
1965; 115: 217-25.
12. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck
AC, Cleary P. Central nervous system HIV-1
infection and AIDS dementia complex. Science 1988;
239: 586-92.
13. Chayt K. Harper ME, Marselle LM, Lewin EB, Rose
RM, Oleske JM, Epstein LG, Wong-Staal F, Gallo
RC. Detection of HTLV-III RNA in lungs of patients
with AIDS and pulmonary involvement. JAMA 1986;
256: 2356-9.
14. De Boer GF, Terpstra C, Houwers DJ. Studies in
epidemiology of maedi/visna in sheep. Res Vet Sci
1979; 26: 202-8.
15. Cutlip RC, Jackson TA, Lemkuhl HD. Lesions of
ovine progressive pneumonia: Interstitial pneumonitis
and encephalitis. Am J Vet Res 1979; 40: 1370-4.
16. Pétursson G, Nathanson N, Georgsson G, Panitch
H, Pálsson PA. Pathogenesis of visna. I. Sequential
virologic, serologic and pathologic studies. Lab Invest
1976; 35: 402-12.
17. Narayan O, Strandberg JD, Griffin DE, Clements
JE, Adams RJ. Aspects of the pathogenesis of visna
in sheep. In: Mims CA, Cuzner ML, Kelly RE,
eds. Viruses and Demyelinating Diseases. London:
Academic Press, 1983: 125-40.
18. Saag MS, Hahn BH, Gibbons J, Li Y, Parks ES,
Parks WP, Shaw GM. Extensive variation of human
immunodeficiency virus type-1 in vivo. Nature 1988;
334: 440-4.
19. Clements JE, Pedersen FS, Narayan O. Genomic
changes associated with antigenic variation of visna
virus during persistent infection. Proc Natl Acad Sci
1980; USA 77: 4454-8.
20. Cheng-Mayer C, Homsy J, Evans LA, Levy JA.
Identification of human immunodeficiency virus
subtypes with distinct pattems of sensitivity to serum
neutralization. Proc Natl Acad Sci 1988; USA 85:
2815-9.
21. Gudnadóttir M. Visna-maedi in sheep. Prog Med
Virol 1974; 18: 336-49.
22. Narayan O, Griffin DE, Chase J. Antigenic shift of
visna vims in persistently infected sheep. Science
1977; 197: 376-8.
23. Narayan O, Wolinsky JS, Clements JE, Strandberg
JD, Griffin DE, Cork LC. Slow virus replication: The
role of macrophages in the persistence and expression
of visna viruses of sheep and goats. J Gen Virol
1983; 59: 345-56.
24. Lutley R, Pétursson G, Pálsson PA, Georgsson G,
Klein J, Nathanson N. Antigenic drift in visna: Vims
variation during long-term infection of Icelandic
sheep. J Gen Virol 1983; 6: 1433-40.
25. Thormar H, Barshatzky MR, Amesen K, Kozlowski
PB. The emergence of antigenic variants is a rare
event in long-term visna vims infection in vivo. J
Gen Virol 1983; 64: 1427-32.
26. Haase AT. The AIDS lentivims connection. Microb
Pathog 1986; I: 1-4.
27. Haase AT. Pathogenesis of lentivims infections.
Nature 1986; 322: 130-6.
28. Georgsson G. Pálsson PA, Pétursson G.
Pathogenesis of visna. In: Serlupi Cresenzi G. ed. A
Multidisciplinary Approach to Myelin Diseases. New
York: Plenum Press, 1987: 303-18.
29. Peluso R, Haase A. Stowring L, Edwards M, Ventura
P. A Trojan horse mechanism for the spread of visna
in monocytes. Virology 1985; 147: 2231-6.
30. Harper ME, Marselle LM, Gallo RC, Wong-Staal
F. Detection of lymphocytes expressing human T-
lymphotropic vims type III in lymph nodes and