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Læknablaðið - 15.10.1990, Page 13

Læknablaðið - 15.10.1990, Page 13
LÆKNABLAÐIÐ 383 spectrum of target cells in the CNS in both infections is apparently similar. As there is increasing evidence that the nervous system is one of the primary target organs of infection with HIV, visna of sheep offers a promising possibility as a model for trials aimed at preventing or treating AIDS. ÞAKKIR Það yrði of langt mál að geta allra sem lagt hafa hönd á plóg á ýmsum stigum þessarar vinnu, en þó skal þökkuð sérstaklega tæknileg aðstoð Elsu Benediktsdóttur, Eyglóar Gísladóttur, Roger Lutley, Steinunnar Amadóttur og Svövu Högnadóttur, ennfremur þökkum við Margréti Kristinsdóttur fyrir frágang handrits. Jafnframt skal Dr. V.V. Joshi þakkað fyrir efnivið úr lungnabólgu í eyðni og Dr. H. Budka og Dr. Kára Stefánssyni fyrir efnivið úr heilabólgu í eyðni. HEIMILDIR 1. Sigurdsson B. Observations on three slow infections of sheep. Br Vet J 1954; 110: 255-70. 2. Sigurdsson B. Thormar H. Pálsson PA. Cultivation of visna virus in tissue culture. Arch Ges Virusforsch 1960; 10: 368-81. 3. Pálsson PA. Maedi and visna in sheep. In: Kimberlin RH, ed. Slow Virus Diseases of Animals and Man. Amsterdam: North-Holland, 1976: 17-43. 4. Georgsson G, Martin JR, Klein J, Pálsson PA, Nathanson N, Pétursson G. Primary demyelination in visna: An ultrastructural study of Icelandic sheep with clinical signs following experimental infection. Acta Neuropathol 1982; 57: 171-8. 5. Gonda MA. Wong-Staal F, Gallo RC, Clements JE, Narayan O, Gilden RV. Sequence homology and morphologic similarity of HTLV-III and visna virus, a pathogenic lentivirus. Science 1985; 227: 170-3. 6. Sonigo P, Alizon M, Staskus K, Klatzmann D, Cole S, Danos O, Retzel E. Tiollais P, Haase A. Wain-Hobson S. Nucleotide sequence of the visna lentivirus: Relationship to the AIDS virus. Cell 1985; 42: 369-82. 7. Braun MJ, Clements JE, Gonda MA. The visna virus genome: Evidence for a hypervariable site in the env gene and sequence homology among lentivirus envelope proteins. J Virol 1987; 61: 4046-54. 8. Thormar H. Visna-maedi infection in cell cultures and in laboratory animals. In: Kimberlin RH, ed. Slow Virus Diseases of Animals and Man. Amsterdam: North-Holland; 1976: 97-114. 9. Popovic M, Samgadharan MG, Read E, Gallo RC. Detection, isolation and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS. Science 1984; 224: 497-500. 10. Sigurdardóttir B, Thormar H. Isolation of a viral agent from the lungs of sheep affected with maedi. J Infect Dis 1964; 114: 55-60. 11. Gudnadóttir M, Pálsson PA. Successful transmission of visna by intrapulmonary inoculation. J Infect Dis 1965; 115: 217-25. 12. Price RW, Brew B, Sidtis J, Rosenblum M, Scheck AC, Cleary P. Central nervous system HIV-1 infection and AIDS dementia complex. Science 1988; 239: 586-92. 13. Chayt K. Harper ME, Marselle LM, Lewin EB, Rose RM, Oleske JM, Epstein LG, Wong-Staal F, Gallo RC. Detection of HTLV-III RNA in lungs of patients with AIDS and pulmonary involvement. JAMA 1986; 256: 2356-9. 14. De Boer GF, Terpstra C, Houwers DJ. Studies in epidemiology of maedi/visna in sheep. Res Vet Sci 1979; 26: 202-8. 15. Cutlip RC, Jackson TA, Lemkuhl HD. Lesions of ovine progressive pneumonia: Interstitial pneumonitis and encephalitis. Am J Vet Res 1979; 40: 1370-4. 16. Pétursson G, Nathanson N, Georgsson G, Panitch H, Pálsson PA. Pathogenesis of visna. I. Sequential virologic, serologic and pathologic studies. Lab Invest 1976; 35: 402-12. 17. Narayan O, Strandberg JD, Griffin DE, Clements JE, Adams RJ. Aspects of the pathogenesis of visna in sheep. In: Mims CA, Cuzner ML, Kelly RE, eds. Viruses and Demyelinating Diseases. London: Academic Press, 1983: 125-40. 18. Saag MS, Hahn BH, Gibbons J, Li Y, Parks ES, Parks WP, Shaw GM. Extensive variation of human immunodeficiency virus type-1 in vivo. Nature 1988; 334: 440-4. 19. Clements JE, Pedersen FS, Narayan O. Genomic changes associated with antigenic variation of visna virus during persistent infection. Proc Natl Acad Sci 1980; USA 77: 4454-8. 20. Cheng-Mayer C, Homsy J, Evans LA, Levy JA. Identification of human immunodeficiency virus subtypes with distinct pattems of sensitivity to serum neutralization. Proc Natl Acad Sci 1988; USA 85: 2815-9. 21. Gudnadóttir M. Visna-maedi in sheep. Prog Med Virol 1974; 18: 336-49. 22. Narayan O, Griffin DE, Chase J. Antigenic shift of visna vims in persistently infected sheep. Science 1977; 197: 376-8. 23. Narayan O, Wolinsky JS, Clements JE, Strandberg JD, Griffin DE, Cork LC. Slow virus replication: The role of macrophages in the persistence and expression of visna viruses of sheep and goats. J Gen Virol 1983; 59: 345-56. 24. Lutley R, Pétursson G, Pálsson PA, Georgsson G, Klein J, Nathanson N. Antigenic drift in visna: Vims variation during long-term infection of Icelandic sheep. J Gen Virol 1983; 6: 1433-40. 25. Thormar H, Barshatzky MR, Amesen K, Kozlowski PB. The emergence of antigenic variants is a rare event in long-term visna vims infection in vivo. J Gen Virol 1983; 64: 1427-32. 26. Haase AT. The AIDS lentivims connection. Microb Pathog 1986; I: 1-4. 27. Haase AT. Pathogenesis of lentivims infections. Nature 1986; 322: 130-6. 28. Georgsson G. Pálsson PA, Pétursson G. Pathogenesis of visna. In: Serlupi Cresenzi G. ed. A Multidisciplinary Approach to Myelin Diseases. New York: Plenum Press, 1987: 303-18. 29. Peluso R, Haase A. Stowring L, Edwards M, Ventura P. A Trojan horse mechanism for the spread of visna in monocytes. Virology 1985; 147: 2231-6. 30. Harper ME, Marselle LM, Gallo RC, Wong-Staal F. Detection of lymphocytes expressing human T- lymphotropic vims type III in lymph nodes and

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