Læknablaðið - 15.10.2012, Blaðsíða 25

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ENGLISH SUMMARY
Bone mineral density of young women with history of anorexia nervosa
Runarsdottir RG, Thorsteinsdottir G, Indridason OS, Sigurdsson G
Objective: A decrease in bone mineral density (BMD) is frequently
seen in patients with anorexia nervosa (AN). This study was designed to
assess BMD of young lcelandic women with current or previous history
of AN and identify predictors which might be targets for preventive
measures.
Material and methods: The study was retrospective. Participants were
women aged 18-40 years, with diagnosis of AN (F50.0, F50.1) attending
the anorexia unit at Landspítali - The National University Hospital of lce-
land - in 2001-2009, who had undergone measurement of BMD by dual-
energy X-ray absorptiometry. A control group consisted of 58 healthy 30
years old women participating in a study of bone health in 2001-2003.
Results: At time of BMD measurement the median body mass index
(BMI: kg/m2) in the AN group (n=40) was 17.4 (12.3-25.2) compared to
23.6 (18.1-43.7) in the control group (p<0,001). Lumbar spine and hip
BMD were 15.3-17.5% lower in AN patients than in control subjects
(p<0.001). In both groups there was a strong correlation between BMD
and body weight (r=0.354-0.604, p<0.05) and lean mass (r=0.425-0.588,
p<0.05). Among patients with AN a correlation was also seen between
BMD and lowest weight during the illness (r=0.482-0.499, p<0.01).
Among the 26 AN patients who had repeated BMD measurement, a
significant decrease in BMD at femoral neck (-6.6%, p=0.030) was
observed in those who lost weight between the measurements (n=9).
Those who had BMI s17.5 between BMD measurements lost 5.5-7.1% of
the BMD at the hip (p<0.05).
Conclusion: Young women with AN have 15% lower bone mass than
healthy young women. The relationship between BMD and body
weight seems to be a continuum across disease states. Increased
body weight may be the most important factor for recovery of bone
mass in AN patients.
Key words: bone mineral density, anorexia nervosa, peak bone mass, body weight.
Correspondence: Gunnar Sigurösson, gunnars@iandspitaii.is
'Faculty of Medicine, University of lceland, 2Department of Psychiatry, Eating Disorder Unit, Landspitali - The National University Hospital of lceland, 3Department of Nephro-
logy, Landspítali, 4Department of Endocrinology, Landspitali.
LÆKNAblaðið 2012/98 529