Læknablaðið - 01.02.2014, Síða 25

LÆKNAblaðið 2014/100 89
ENGLISH SUMMARY
We report the first four cases of Melioidosis treated in Iceland and
review the literature. Melioidosis is caused by the saprophytic Gram
negative bacteria Burkholderia pseudomallei. Most disease occurs in
residents of Southeast-Asia and North-Australia. The most common pre-
sentation of Melioidosis is pneumonia but as these cases demonstrate
the infection has protean manifestations and B. pseudomallei can infect
nearly every organ. It is important to notify the laboratory of the possi-
bilty of Melioidosis as the bacteria can be difficult to identify and poses
an infection risk to laboratory staff. Also, B. pseudomallei is resistant to
many of the antibiotics normally used to treat pneumonia and due to its
intracellular persistance requires prolonged therapy.
Melioidosis, first four cases in iceland
Gudmundsdottir Th1, Asgeirsson H1, Hardarson HS2, Thorisdottir AS1,3
key words: Burkholderia pseudomallei, Melioidosis, vertebral osteomyelitis, splenic abscesses, pneumonia.
Correspondance: Anna S. Þórisdóttir annathor@landspitali.is
1Landspitali University Hospital Iceland, 2Dept. of Medicine; Dept. of Clinical Microbiology; 3Dept. of Infectious Diseases.
Heimildir
1. Whitmore A, Krishnaswani CS. An account of the
discovery of a hitherto undescribed infective disease occ-
urring among the population of Rangoon. Indian Medical
Gazette 1912; 47: 262-7.
2. White NJ. Melioidosis Seminar. Lancet 2003; 361: 1714-22.
3. Cheng AC, Currie BJ. Melioidosis: Epidemiology,
Pathopysiology, and Management. Clin Microbiol Rev
2005; 18: 383-416.
4. Currie BJ. Melioidosis: an important cause of pneumonia
in residents of and travellers returned from endemic
regions. Eur Respir J 2003; 22: 542-50.
5. Currie, BJ. Burkholderia pseudomallei and Burkholderia
mallei: Melioidosis and Glanders. Mandell: Mandell,
Douglas and Bennett´s Principles and Practice of
Infectious Diseases 7th ed. 2010; 2869-77.
6. Currie BJ, Fischer DA, Howard DM, Burrow JNC,
Selvanayagam S, Snelling et al. The epidemiology of
melioidosis in Australia and Papua New Guinea. Acta
Trop 2000; 74: 121-7.
7. Rubin HL, Alexander AD, Yager RH. Melioidosis –a
military problem? Mil Med 1963; 128: 538-42.
8. Easton A, Haque A, Chu K, Lukaszewski R, Bancroft G. A
critical role for neutrophils in resistance to experimental
infection with Burkholderia pseudomallei. J Infect Dis
2007; 195: 99-107.
9. Kronmann KC, T ruett AA, Braden RH, Crum-Cianflone
NF. Melioidosis after brief exposure: A serologic survey in
US Marines. Am J Trop Med Hyg 2009; 80: 182-4.
10. Gibney KB, Cheng AC, Currie BJ. Cutaneous Melioidosis
in th Tropical Top End of Australia: A Prospective Study
and Review of the Literature. Clin Infect Dis 2008; 47: 603-
9.
11. Peacock SJ, Chieng G, Cheng AC, Dance DA, Amornchai P,
Wongsuvan G, et al. Comparison of Ashdown‘s medium,
Burkholderia cepacia medium, and Burkholderia pseudo-
mallei selective agar for clinical isolation of Burkholderia
pseudomallei. J Clin Microbiol 2005; 43: 5359-61.
12. Inglis TJJ. Comparison of Diagnostic Laboratory Methods
for Identification of Burkholderia pseudomallei. J Clin
Microbiol 2005; 43: 2201-6.
13. Suputtamongkol Y, Chaowagul W, Chetchotisakd P,
Lertpatanasuwun N, Intaranongpai S, Ruchutrakool
P, et al. Risk Factors for Melioidosis and Bacteremic
Melioidosis. Clin Infect Dis; 1999; 29: 408-13.
14. Limmathurotsakul D, Chaowagul W, Day NPJ, Peacock SJ.
Patterns of Organ Involvement in Recurrent Melioidosis.
Am J Trop Med Hyg 2009; 81: 335-7.
15. Hodgson G, Engler C et al. Comparison of Routine Bench
and Molecular Diagnostic Methods in Identification of
Burkholderia pseudomallei. J Clin Microbiol 2009; 43:
1578-80.
16. Center for Disease Control and Prevention. Laboratory
exposure to Burkholderia pseudomallei-Las Angeles,
California. MMWR Morb Mortal Wkly Rep 2004; 53: 988-
90.
S J Ú k R a T i l F E l l i