Læknablaðið - 01.10.2015, Side 28

468 LÆKNAblaðið 2015/101
ENgLISH SUMMArY
Germ cells are the precursors to the gametes that carry genetic and
epigenetic information between human generations and generate a
new individual. Because germ cells are specified early during embryo-
genesis, at the time of embryo implantation, they are inaccessible for
research. our understanding of their biology has therefore developed
slowly since their identification over one hundred years ago. As a result
of research into the properties of human and mouse embryonic stem
cells and primordial germ cells, scientists have now succeeded in effi-
ciently generating human primordial germ cells in culture by embryonic
stem cell and induced pluripotent stem cell culture. In this review we
will discuss the state of our knowledge of human primordial germ cells
and how research into the pluripotent properties of human and mouse
embryonic germ cells has led to this breakthrough. In addition we will
discuss the possible utilization of a cell culture system of human pri-
mordial germ cells for research into and treatment of germ cell related
abnormalities.
Human Primordial Germ Cell Specification – breakthrough in Culture and
Hopes for Therapeutic Utilization
Erna Magnúsdóttir
key words: primordial germ cells, pluripotency.
Correspondence: Erna Magnúsdóttir, erna@hi.is
Y F I R L I T S G R E I N
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