Læknablaðið

Árgangur

Læknablaðið - 01.10.2016, Síða 16

Læknablaðið - 01.10.2016, Síða 16
432 LÆKNAblaðið 2016/102 R A N N S Ó K N ENGLISH SUMMARY Introduction: Laparoscopic roux-en-y gastric bypass (LRYGB) has been performed at Landspitali University Hospital (LSH) since 2001. The procedure represents an important treatment option for morbidly obese patients. The aim of this study is to evaluate the long-term results of these operations in Iceland. Material and methods: All 772 consecutive patients undergoing LRYGB at LSH during 2001-2015 were included. Information was collected from a prospective database. Successful weight loss was defined as body mass index (BMI) less than 33 kg/m2 or excess body mass index loss (EBMIL) more than 50%. Results: Mean age of patients was 41 years and 83% were females. Mean pre-operative weight was 127 kg (±20) and mean BMI was 44 (±6). Mean %EBMIL was 80% after 1.5 year, 70% after 5 years and 64% after 10-13 years. 85% of patients had successful weight loss with a mean follow-up time of 7.4 years. Pre-operatively patients on average had 2.8 obesity related comorbid diseases. 71% of patients with type 2 diabetes were in full remission after surgery. One third of patients with hypertension and one third of patients with hyperlipidemia achieved full remission after surgery. 37 patients (5%) had an early complication and 174 (25%) had a late complication that frequently needed surgical solution. Most patients (78%) needed repeated adjustment of vitamins and minerals often many years after surgery. Conclusion: Majority of patients achieved a successful weight loss and most obesity related comorbidities are still in remission 7.4 years after surgery. Early complications were rare but one fourth of patients had late complications. Life long follow-up is of utmost importance after gastric bypass surgery. Outcome of gastric bypass surgery in Iceland 2001-2015 Rósamunda Þórarinsdóttir1, Vilhjálmur Pálmason1, Björn Geir Leifsson2, Hjörtur Gíslason2 1Department of Medicine, University of Iceland, 2Surgical department Landspitali University Hospital. Key words: gastric bypass surgery in Iceland 2001-2015. Correspondence: Hjörtur Gíslason, hjorturg@landspitali.is Heimildir 1. Obesity: preventing and managing the global epidem- ic. Report of a WHO consultation. World Health Organization technical report series. 2000; 894: i-xii, 1-253. 2. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, Paciorek CJ, et al. National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet 2011; 377: 557-67. 3. Þórsson B, Aspelund T, Harris TB, Launer LJ, Guðnason V. Þróun holdafars og sykursýki í 40 á Íslandi. Læknablaðið 2009; 95: 259-66. 4. Alberti KG, Eckel RH, Grundy SM, Zimmet PZ, Cleeman JI, Donato KA, et al. Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009; 120: 1640-5. 5. Alberti KG, Zimmet P, Shaw J, Grundy SM. The metabolic syndrome--a new worldwide definition. Lancet 2005; 366: 1059-62. 6. Sundstrom J, Riserus U, Byberg L, Zethelius B, Lithell H, Lind L. Clinical value of the metabolic syndrome for long term prediction of total and cardiovascular mortality: prospective, population based cohort study. BMJ 2006; 332: 878-82. 7. Batsis JA, Romero-Corral A, Collazo-Clavell ML, Sarr MG, Somers VK, Lopez-Jimenes F. Effect of bariatric surgery on the metabolic syndrome: a population-based, long-term controlled study. Mayo Clin Proc 2008; 83: 897-907. 8. Calle EE, Thun MJ, Petrelli JM, Rodriguez C, Heath CW, Jr. Body-mass index and mortality in a prospective cohort of U.S. adults. N Engl J M 1999; 341: 1097-105. 9. Zoppini G, Verlato G, Leuzinger C, Zamboni C, Brun E, Bonora E, et al. Body mass index and the risk of mortality in type II diabetic patients from Verona. Int J Obes Relat Metab Disord 2003; 27: 281-5. 10. Bianchini F, Kaaks R, Vainio H. Overweight, obesity, and cancer risk. Lancet Oncology 2002; 3: 565-74. 11. Avenell A, Brown TJ, McGee MA, Campbell MK, Grant AM, Broom J, et al. What are the long-term benefits of weight reducing diets in adults? A systematic review of randomized controlled trials. J Hum Nutr Diet 2004; 17: 317-35. 12. Avenell A, Brown TJ, McGee MA, Campbell MK, Grant AM, Broom J, et al. What interventions should we add to weight reducing diets in adults with obesity? A systematic review of randomized controlled trials of adding drug therapy, exercise, behaviour therapy or combinations of these interventions. J Hum Nutr Diet 2004; 17: 293-316. 13. Dansinger ML, Gleason JA, Griffith JL, Selker HP, Schaefer EJ. Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial. JAMA 2005; 293: 43-53. 14. Bravata DM, Sanders L, Huang J, Krumholz HM, Olkin I, Gardner CD, et al. Efficacy and safety of low carbohydrate diets: a systemic review. JAMA 2003; 289: 1837-50. 15. Yanovski SZ, Yanovski JA. Long-term drug treatment for obesity. A systematic and clinical review. JAMA 2014; 311: 74-86. 16. Svetkey LP, Stevens VJ, Brantley PL, Apple LJ, Hollis JF, Loria CM, et al. Comparison of strategies for sustaining weight loss: the weight loss maintenance randomized controlled trial. JAMA 2008; 299: 1139-48. 17. Buchwald H, Avidor Y, Braunwald E, Jensen MD, Pories W, Fahrbach K, Schoelles K, et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004 13; 292: 1724-37. 18. Adams TD, Gress RE, Smith SC, Halversen RC, Simper SC, Rosamond WD, et al. Long-term mortality after gastric bypass surgery. N Engl J Med 2007; 357: 753–61. 19. Christou NV, Sampalis JS, Liberman M, Look D, Auger S, McLean AP, et al. Surgery decreases long-term mortality, morbidity, and health care use in morbidly obese patients. Ann Surg 2004; 240: 416-23; discussion 23-4. 20. Eliasson B, Liakopoulos V, Franzén S, Näslund I, Svensson AM, Ottoson J, Gudbjörnsdóttir S. Cardiovascular dise- ase and mortality in patients with type 2 diabetes after bariatric surgery in Sweden: a nationwide, matched, observational cohort study. Lancet Diab Endocrinol 2015; 3: 847-54. 21. Fried M, Yumuk V, Oppert JM, Scopinaro N, Torres A, Weiner R, et al. Interdisciplinary European guidelines on metabolic and bariatric surgery. Obesity Surg 2014; 24: 42-55. 22. Buse JB, Caprio S, Cefalu WT, Ceriello A, Del Prato S, Inzucchi SE, Et al. How do we define cure of diabetes? Diab Care 2009; 32: 2133-5. 23. Birgisson G, Guðmundsson L. Offitumeðferð á Reykjalundi. Sjúkraþjálfarinn 2005; 32: 22-4. 24. Hannesdóttir SH, Guðmundsson ÁL, Jóhannsson E. Heilsufarslegar breytingar sjúklinga í atferlismiðaðri offitumeðferð. Læknablaðið 2011; 97: 597-602. 25. Olbers T, Lönroth H, Fagevik-Olsen M, Lundel L. Laparoscopic gastric bypass: development of technique, respiratory function, and long-term outcome. Obes Surg 2003; 13: 364-370. 26. Carlin AM, Zeni TM, English WJ, Hawasli AA, Genaw JA, Krause KR, et al. The comparative effectiveness of sleeve gastrectomy, gastric bypass, and adjustable gastric banding procedures for the treatment of morbid obesity. Ann Surg 2013; 257: 791-7. 27. Sovik TT, Taha O, Aasheim ET, Engstrom M, Kristinsson J, Bjorkman S, et al. Randomized clinical trial of laparoscopic gastric bypass versus laparoscopic duodenal switch for superobesity. Br J Surg 2010; 97: 160-6. 28. Lujan JA, Frutos MD, Hernandez Q, Liron R, Cuenca JR, Valero G, et al. Laparoscopic versus open gastric bypass in the treatment of morbid obesity: a randomized prospecti- ve study. Ann Surg 2004; 239: 433-7. 29. Nguyen NT, Goldman CD, Ho HS, Gosselin RC, Singh A, Wolfe BM. Systemic stress response after laparoscopic and open gastric bypass. J Am Coll Surg 2002; 194: 557-66. 30. Westling A, Gustavsson S. Laparoscopic vs open Roux- en-Y gastric bypass: a prospective, randomized trial. Obes Surg 2001; 11: 284-92. Heimildir 31-57 eru birtar á heimasíðu blaðsins.

x

Læknablaðið

Beinleiðis leinki

Hvis du vil linke til denne avis/magasin, skal du bruge disse links:

Link til denne avis/magasin: Læknablaðið
https://timarit.is/publication/986

Link til dette eksemplar:

Link til denne side:

Link til denne artikel:

Venligst ikke link direkte til billeder eller PDfs på Timarit.is, da sådanne webadresser kan ændres uden advarsel. Brug venligst de angivne webadresser for at linke til sitet.