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Læknablaðið - 15.10.1989, Qupperneq 23

Læknablaðið - 15.10.1989, Qupperneq 23
LÆKNABLAÐIÐ 291 15,9 ár frá aðgerð og hjá sex sjúklingum >20 ár. Við teljum því að það eina 0,9 cm æxli sem hafði myndað meinvörp réttlæti ekki ristilbrottnám hjá þeim 19% sjúklinga sem höfðu æxli á bilinu 0,9-1,4 cm því enginn annar sjúklingur í þem hópi fékk merki um endurvöxt krabbalíkis. Þakkir: Grein þessi er hluti verkefnis sem styrkt var af Vísindasjóð íslands og Minningarsjóð Bergþóru Magnúsdóttur og Jakobs J. Bjamasonar. Yfirlæknar deilda og sjúkrahúsa veittu góðfúslega aðgang að sjúkra- og rannsóknarskýrslum. SUMMARY Seventy-eight histologically verified cases of appendiceal carcinoid tumors were diagnosed in Iceland in the 30-year period 1955-1984. These have been retrospectively analysed as demonstrated in Tables I-VI. Appendiceal carcinoids were 53% of all carcinoid tumors diagnosed in that period and 66% of gastrointestinal carcinoids. The annual crude incidence of appendiceal carcinoids was 1,2 per 100.000 inhabitants (females 1,9 and males 0,62). The age ranged from 4 to 72 years, average 29 years. Children under the age of 16 years were 18. The tumor was not diagnosed preoperatively in any patient. The indication for appendectomy was acute appendicitis in 51% of the patients. Average tumor size as measured in histological sections was 0,60 cm - 79% were located in the distal third of the appendix and in 28% of the cases the tumor had invaded the mesoappendix. One patient with a 0,9 cm primary tumor had metastases. In 74 patients a standard appendectomy was the only surgical procedure performed. On Dec lst 1986 six of the 78 patients had died, but none of the carcinoid tumor. All other patients were alive without evident recurrent disease with an average follow-up time of 15 years. We conclude that standard appendectomy is adequate treatment for the vast majority of carcinoid tumors of the appendix and that complementary treatment or follow-up investigations are rarely indicated. HEIMILDIR 1. Ahlman H. Midgut carcinoid tumors. Surg Ann 1986; 18: 65-93. 2. Godwin JD. Carcinoid tumors. An analysis of 2837 cases. Cancer 1975; 36: 560-9. 3. Anderson JR, Wilson BG. Carcinoid tumours of the appendix. Br J Surg 1985; 72; 545-6. 4. Mártensson H. Gut endocrine tumors (Thesis). University of Lund 1983. 5. Moertel CG, Dockerty MB, Judd ES. Carcinoid tumors of the vermiform appendix. Cancer 1968; 21: 270-8. 6. Moertem CG, Weiland LH, Nagomey DM, Dockerty MB. Carcinoid tumor of the appendix: Treatment and prognosis. N Eng J Med 1987; 317: 1699-1701. 7. Andersson Á, Bergdahl L. Carcinoid tumors of the appendix in children. Acta Chir Scand 1977; 143: 173-5. 8. Dymock RB. Pathological changes in the appendix: review of 1000 cases. Pathology 1977; 9: 331-9. 9. Berge T, Linell F. Carcinoid tumors. Frequency in a defined population during a 12-year period. Acta Path Microbiol Scand Sect A 1976; 84: 322-30. 10. Syracuse DC, Perzin KH, Price JB, Wiedel PD, Mesa-Tejada R. Carcinoid tumors of the appendix. Ann Surg 1979; 190: 58-63. 11. Þorkelsson Þ, Jóhannsson JH. Botnlangabólga og aðrir sjúkdómar í botnlanga. Læknaneminn 1984; 37: 45-52. 12. Aho AJ, Heinonen RJ, Laurén PA. Carcinoid tumours of the appendix. Acta Chir Scand 1971; 137: 801-6. 13. Bowman GA, Rosenthal D. Carcinoid tumors of the appendix. Am J Surg 1983; 146: 700-3. 14. Glasser CM, Bhagavan BS. Carcinoid tumors of the appendix. Arch Pathol Lab Med 1980; 104: 272-5. 15. Lau W, Fan S, Yiu T et al. The clinical significance of routine histopathologic study of the resected appendix and safety of appendiceal inversion. Surg Gynecol Obstet 1986; 162: 156-8. 16. Ponka JL. Carcinoid tumors of the appendix. Am J Surg 1973; 126: 77-83. 17. Svendsen LB, Búlow S. Carcinoid tumours of the appendix in young patients. Acta Chir Scand 1971; 146: 137-9. 18. Ryden SE, Drake RM, Franciosi RA. Carcinoid tumors of the appendix in children. Cancer 1975; 36: 1538-42.
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