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ENGLISH SUMMARY
Brain abscess - overview
Sveinsson OA, Asgeirsson H, Olafsson IH
Brain abscess is a life threatening illness, demanding rapid diagnosis
and treatment. Its development requires seeding of an organism into
the brain parenchyma, often in an area of damaged brain tissue or in a
region with poor microcirculation. The lesion evolves from a cerebritis
stage to capsule formation. Brain abscesses can be caused by con-
tiguous or haematogenous spread of an infection, or by head trauma/
neurosurgical procedure. The most common presentation is that of
headache and vomiting due to raised intracranial pressure. Seizures
have been reported in up to 50% of cases. Focal neurological deficits
may be present, depending on the location of the lesion. Treatment of
a brain abscess involves aspiration or excision, along with parenteral
antibiotic therapy. The outcome has improved dramatically in the last
decades due to improvement in diagnostic techniques, neurosurgery,
and broad-spectrum antibiotics. The authors provide an overview of the
pathogenesis, diagnosis and management of brain abscesses.
Keywords: cerebral abscess, cerebritis, magnetic resonance imaging, antibiotic treatment, surgical treatment.
Correspondence: Olafur Sveinsson, olafur.sveinsson@karolinska.se
’Department of Neurology, Karolinska University Hospital, Stockholm, Sweden. 2Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden. 3Depart-
ment of Neurosurgery, Landspítali The University Hospital of lceland, Reykjavik.
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