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Læknablaðið - 15.03.2013, Síða 15

Læknablaðið - 15.03.2013, Síða 15
RANNSÓKN Heimildir 1. Bjömsson G. Prevalence and causes of blindness in Iceland, with special reference to glaucoma simplex. Am J Ophthalmol 1955; 39:202-8. 2. Bjömsson G. The Borgames Eye Study. Nordic Council Arctic Medical Research Report 1980; 26: 34-9. 3. Jonasson F, Thordarson K. Prevalence of ocular disease and blindness in a mral area in the eastem region of Iceland during 1980 throughl984. Acta Ophthalmol Suppl 1987; 182: 40-3. 4. Organisation for Economic Co-operation and Develop- ment. 2012; oecd.org/iceland/Briefing NotelCELAND 2012.pdf - nóvember 2012. 5. Hagstofa íslands 2012. hagstofa.is/Hagtolur/Mannfjoldi - nóvember 2012. 6. Klein R, Klein BE, Linton KL, De Mets DL. The Beaver Dam Eye Study: Visual acuity. Ophthalmology 1991; 98: 1310-5. 7. Attebo K, Mitchell P, Smith W. Visual acuity and the causes of visual loss in Australia. The Blue Mountains Eye Study. Ophthalmology 1996; 103: 357-64. 8. Buch H, Vinding T, La Cour M, Nielsen NV. The preva- lence and causes of bilateral and unilateral blindness in an elderly urban Danish population. The Copenhagen City Eye Study. Acta Ophthalmol Scand 2001; 79:441-9. 9. Ivers RQ, Cumming RG, Mitchell P, Attebo K. Visual impairment and falls in older adults: the Blue Mountains Eye Study. J Am Geriatr Soc 1998; 46: 58-64. 10. Javitt JC, Zhouz, Wilke RJ. Association between vision loss and higher medical care costs in Medicare beneficiaries. Ophthalmology 2007; 144:238-45. 11. World Health Organization. Intemational statistical classification of diseases and related health problems lOth revision (ICD-10) Version for 2010. who.int/classifica- tions/icd/en - nóvember 2012. 12. Gunnlaugsdottir E, Amarsson A, Jonasson F. Prevalence and causes of visual impairment and blindness in Icelanders aged 50 years and older: the Reykjavik Eye Study. Acta Ophthalmol 2008; 86:778-85. 13. Gunnlaugsdottir E, Amarsson A, Jonasson F. Five-year incidence of visual impairment and blindness in older Icelanders: the Reykjavik Eye Study. Acta Ophthalmol 2010; 88; 358-66. 14. Jonasson F, Amarsson A, Sasaki H, Peto T, Sasaki K, Bird AC. The prevalence of age-related maculopathy in Iceland: Reykjavik Eye Study. Arch Ophthalmol 2003; 121: 379-85. 15. Jonasson F, Amarsson A, Peto T, Sasaki H, Sasaki K, Bird AC. 5-year incidence of age-related maculopathy in the Reykjavik Eye Study. Ophthalmology 2005; 112:132-8. 16. Jonasson F, Damji KF, Amarsson A, Sverrisson T, Wang L, Sasaki H, et al. Prevalence of open-angle giaucoma in Iceland: Reykjavik Eye Study. Eye (Lond) 2003; 17: 747-53. 17. Arnarsson Á, Jónasson F, Katoh N, Sasaki H, Jónsson V, Kojima M, et al. Áhættuþættir skýmyndunar í berki og kjama augasteins Reykvíkinga 50 ára og eldri. Reykjavíkuraugnrannsóknin. Læknablaðið 2002; 88: 727- 31. 18. Katoh N, Jonasson F, Sasaki H, Kojima M, Ono M, Takahashi N, et al. Reykjavik Eye Study Group. Cortical lens opacification in Iceland. Risk factor analysis— Reykjavik Eye Study. Acta Ophthalmol Scand 2001; 79: 154-9. 19. Gudmundsdottir E, Jonasson F, Jonsson V, Stefánsson E, Sasaki H, Sasaki K. "With the rule" astigmatism is not the mle in the elderly. Reykjavik Eye Study: a population based study of refraction and visual acuity in citizens of Reykjavik 50 years and older. Iceland-Japan Co-Working Study Groups. Acta Ophthalmol Scand 2000; 78: 642-6. 20. Gudmundsdottir E, Amarsson A, Jonasson F. Five-year refractive changes in an adult population: Reykjavik Eye Study. Ophthalmology 2005; 112:672-7. 21. Olsen T, Amarsson A, Sasaki H, Sasaki K, Jonasson F. On the ocular refractive components: the Reykjavik Eye Study. Acta Ophthalmol Scand 2007; 85: 361-6. 22. Klein R, Wang Q, Klein BE, Moss SE, Meuer SM. The relationship of age-related maculopathy, cataract, and glaucoma to visual acuity. Invest Ophthalmol Vis Sci 1995; 36:182-91. 23. Munoz B, West SK, Rubin GS, Schein OD, Quigley HA, Bressler SB, et al. Causes of blindness and visual impair- ment in a population of older Americans: The Salisbury Eye Evaluation Study. Arch Ophthalmol 2000; 118:819-25. 24. Wang JJ, Foran S, Mitchell P. Age-specific prevalence and causes of bilateral and unilateral visual impairment in older Australians: the Blue Mountains Eye Study. Clin Experiment Ophthalmol 2000; 28:268-73. 25. Foran S, Mitchell P, Wang JJ. Five-year change in visual acuity and incidence of visual impairment: the Blue Mountains Eye Study. Ophthalmology 2003; 110: 41-50. 26. Sverrisson T. Visual impairment in patients with chronic open angle glaucoma. Acta Ophthalmol 1990: 68 (suppl 195): 71-3. 27. Umferðarstofa. Reglugerð um ökuskírteini nr. 830/2011. III. Viðauki, liður 6.1. Lágmarkskröfur um andlega og líkamlega hæfni til að stjóma vélknúnu ökutæki. 28. Geirsdottir A, Jonsson O, Thorisdottir S, Helgadottir G, Jonasson F, Stefansson E, et al. Population-based incidence of exudative age-related degeneration and ranibizumab treatment load. Br J Ophthalmol 2012; 96:444-7. 29. Age-related eye disease study research group. Randomized placebo controlled clinical trial of high dose supplementation with vitamin C, E, betacarotin and zinc for age related macular degeneration and vision loss. AREDs Report no. 8. Arch Ophthalmol 2001; 119:1417-36. 30. Stefánsson E, Bek T, Porta M, Larsen N, Kristinsson JK, Agardh E. Screening and prevention of diabetic blindness. Acta Ophthalmol Scand 2000; 78: 374-85. ENGLISH SUMMARY Visual impairment and blindness in lcelanders aged 50 years and older - The Reykjavík Eye Study Gunnlaugsdóttir E, Arnarsson AM, Jónasson F Introduction: The purpose of this study was to examine the cause- specific prevalence and 5-year incidence of visual impairment and blindness among middle-aged and older citizens of Reykjavík. Material and methods: A random sample of 1045 persons aged 50 years or older underwent a detailed eye examination in 1996 and 846 of the survivors participated in a follow-up examination in 2001. Visual impairment was defined according to World Health Organization defini- tions as a best-corrected visual acuity of <6/18 but no worse than 3/60, or visual field of 25° and <10° around a fixation point in the better eye. Best-corrected visual acuity of <3/60 in the better eye was defined as blindness. The causes of visual impairment or blindness were determ- ined for all eyes with visual loss. Results: The prevalence of bilateral visual impairment and blindness was 1.0% (95% Cl 0.4-1.6) and 0.6% (95% Cl 0.1-1.0), respectively and the 5-year incidence was 1.1 % (95% Cl 0.4-1.8) and 0.4% (95% Cl 0.0- 0.8), respectively. The prevalence of visual impairment among 60-69 year old participants was 0.6%, but among those aged 80 years or older the prevalence was 7.9%. The major cause of bilateral visual impairment and blindness both at baseline and follow-up was age-related macular degeneration. Cataract accounted for less severe visual loss. The two most common causes of unilateral visual impairment at baseline were amblyopia and cataract. Cataract was the main cause of unilateral visual impairment at 5-year follow-up. Conclusion: Prevalence and 5-year incidence of both uni- and bilateral visual impairment and blindness increases with age. Age-related macular degeneration was the leading cause of severe visual loss in this population of middle-aged and older lcelanders. Key words: Age-related macular degeneration, blindness, cataract, incidence, prevalence, visualimpairment. Correspondence: Elín Gunnlaugsdóttir elingun@gmail.com 'Department of Ophthalmology, Landspítali University Hospital, Reykjavík, lceland, 2Faculty of Medicine, University of lceland, Reykjavík,3Neuroscience research, University of Akur- eyri, Akureyri. LÆKNAblaðið 2013/99 127

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