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Læknablaðið - 15.10.2002, Side 18

Læknablaðið - 15.10.2002, Side 18
FRÆÐIGREINAR / ALVARLEGAR AUKAVERKANIR KÍNÍNS Höfundar þessarar greinar tilkynntu Lyfjastofnun formlega um tilfellin í janúar á þessu ári og í kjölfarið var tekin ákvörðun um að afturkalla heimild til lausasölu kíníns. Þetia verður að teljast skynsamleg ráðstöfun í ljósi þeirra alvarlegu aukaverkana sem lyfið getur valdið. Þótt ekki sé lengur völ á kíníni í lausasölu er lík- legt að notkun lyfsins verði áfram umtalsverð og er nauðsynlegt að læknar sem ávísa lyfinu til að fyrir- byggja vöðvakrampa í ganglimum ígrundi vel ávinn- ing og áhættu og séu á verði gegn aukaverkunum þess. Sú takmörkun á aðgengi sem felst í stöðvun á lausasölu kíníns hefur þó ekki áhrif á útsetningu fólks fyrir kíníni í neysludrykkjum. Loks er mikilvægt að vara almenning við aukaverkunum kíníns og íhuga ætti prentun upplýsinga um þær á umbúðir Iyfsins og á ílát drykkja sem innihalda þetta efni. Þakkir Höfundar þakka Ingu Skaftadóttur líffræðingi, Ónæm- isfræðideild Landspítala, fyrir greiningu kínínháðra mótefna í sermi. Heimildir 1. Moss HK, Herrmann LG. The use of quinine for relief of night cramps in the extremities. JAMA 1940; 115:1358-9. 2. McGee SR. Muscle cramps. Arch Intern Med 1990; 150:511-8. 3. Goldfrank LR, Osborn H. Quinine. In: Goldfrank LR, Flomenbaum NE, Lewin NA, Weisman RS, Howland RS, editors. Goldfrank's Toxicologic Emergencies. Sixth ed. East Norwalk, CT: Appleton & Lange, 1998: 337-40. 4. Belkin G. Cocktail purpura. An unusual case of quinine sensi- tivity. Ann Intern Med 1967; 66: 583-6. 5. Spearing RL, Hickton CM, Sizeland P, Hannah A, Bailey RR. Quinine-induced disseminated intravascular coagulation. Lancet 1990; 336:1535-7. 6. Gottschall JL, Elliot W, Lianos E, McFarland JG, Wolfmeyer K, Aster RH. Quinine-induced immune thrombocytopenia associated with hemolytic-uremic syndrome: a new clinical entity. Blood 1991;77:306-10. 7. Maguire RB, Stroncek DF, Campbell AC. Recurrent pancyto- penia, coagulopathy, and renal failure associated with multiple quinine-dependent antibodies. Ann Intem Med 1993; 119: 215-7. 8. Stroncek DF, Vercellotti GM, Hammerschmidt DE, Christie DJ, Shankar RA, Jacob HS. Characterization of multiple quinine-dependent antibodies in a patient with episodic hemo- lytic uremic syndrome and immune agranulocytosis. Blood 1992; 80:241-8. 9. Vipan WH. Quinine as a cause of purpura. Lancet 1865; ii: 37. 10. Shrager J, Kean BH. Purpura as a complication of malaria. Am J Med Sci 1946; 212:54-9. 11. Bolton FG, Young R. Observations on cases of thrombocyto- penic purpura due to quinine, sulphamezathine and quinidine. J Clin Path 1953; 6:320-3. 12. Chong BH, Du X, Berndt MC, Horn S, Chesterman CN. Characterization of the binding domains on platelet glycopro- teins Ib-IX and Ilb-IIIa complexes for the quinine/quinidine- dependent antibodies. Blood 1991; 77: 2190-9. 13. Gottschall JL, Neahring B, McFarland JG, Wu GG, Weite- kamp LA, Aster RH. Quinine-induced immune thrombocyto- penia with hemolytic-uremic syndrome: clinical and sero- Iogical findings in nine patients and review of literature. Am J Hematol 1994; 47: 283-9. 14. Salama A, Mueller-Eckhardt C. Immune-mediated blood cell dyscrasias related to drugs. Semin Hematol 1992; 29: 54-63. 15. Remuzzi G, Ruggenenti P. The hemolytic uremic syndrome. Kidney Int 1995; 48: 2-19. 16. Karmali MA, Steele BT, Petric M, Lim C. Sporadic cases of haemolytic-uraemic syndrome associated with faecal cyto- toxin and cytotoxin-producing Escherichia coli in stools. Lancet 1983; 1: 619-20. 17. Elliot HL, Trash DB. Intravascular coagulation induced by quinine: Unexpected hazard of „bitter lemon“. Scott Med J 1979; 24: 244-5. 18. Barr E, Douglas JF, Hill CM. Recurrent acute hypersensitivity to quinine. BMJ 1990; 301:323. 19. McDonald SP, Shanahan EM, Thomas AC, Roxby DJ, Berou- kas D, Barbara JAJ. Quinine-induced hemolytic uremic synd- rome. Clin Nephrol 1997; 47: 397-400. 20. Glynne P, Salama A, Chaudhry A, Swirsky D, Lightstone L. Quinine-induced immune thrombocytopenic purpura followed by hemolytic uremic syndrome. Am J Kidney Dis 1999; 33: 133-7. 21. Crum NF, Gable P. Quinine-induced hemolytic-uremic synd- rome. South Med J 2000; 93: 726-8. 22. Kojouri K, Vesely SK, George JN. Quinine-associated throm- botic thrombocytopenic purpura-hemolytic uremic syndrome: frequency, clinical features, and long-term outcomes. Ann Intern Med 2001; 135:1047-51. 23. Abdulla AJ, Jones PW, Pearce VR. Leg cramps in the elderly: prevalence, drug and disease associations. Int J Clin Pract 1999; 53: 494-6. 24. Moake JL. Haemolytic-uraemic syndrome: basic science. Lancet 1994; 343: 393-7. 25. Galbusera M, Remuzzi A, Benigni A, Rossi C, Remuzzi G. A novel interpretation of the role of von Willebrand factor in thrombotic microangiopathies based on platelet adhesion studies at high shear rate flow. Am J Kidney Dis 2000; 36: 695-702. 26. Kedia RK, Wright AJ. Quinine-mediated disseminated intra- vascular coagulation. Postgrad Med J 1999; 75: 429-30. 27. Morton AP. Quinine-induced disseminated intravascular coagulation and haemolytic-uraemic syndrome. Med J Aust 2002; 176:351. 28. Worden AN, Frape DL, Shephard NW. Consumption of quinine hydrochloride in tonic water. Lancet 1987; 1: 271-2. 29. Man-Son-Hing M, Wells G. Meta-analysis of efficacy of quinine for treatment of nocturnal leg cramps in elderly people. BMJ 1995; 310:13-7. 30. Man-Son-Hing M, Wells G, Lau A. Quinine for nocturnal leg cramps: a meta-analysis including unpublished data. J Gen Intern Med 1998; 13: 600-6. 31. Jansen PHP, Veenhuizen KCW, Wesseling AIM, de Boo Th, Verbeek ALM. Randomised controlled trial of hydroquinine in muscle cramps. Lancet 1997; 349: 528-32. 32. Diener HC, Dethlefsen U, Dethlefsen-Gruber S, Verbeek P. Effectiveness of quinine in treating muscle cramps: a double- blind, placebo-controlled, parallel-group, multicentre trial. Int J Clin Pract 2002; 56: 243-6. 33. US Department of Health and Human Services. Drug products for the treatment and/or prevention of noctumal leg muscle cramps for over-the-counter human use. Federal Register 1994; 59:43234-52. 722 Læknablaðið 2002/88

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