Læknablaðið - 15.01.2011, Page 29

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Heimildir 61-87 eitigöngu birtar á heimasíðu Læknablaðsins
Wernicke’s encephalopathy in chronic alcoholics
Wernicke’s encephalopathy (WE) is caused by thiamine
(vitamin B,) deficiency and most commonly found in
individuals with chronic alcoholism and malnutrition.
Clinically, its key features are mental status disorders and
oculomotor abnormalities as well as stance and gait ataxia.
The diagnosis of WE is frequently missed although delay
of appropriate treatment can lead to death or Korsakoff's
amnestic syndrome. It is therefore crucial in suspected
cases of WE, not to await confirmation of diagnosis,
but immediately administer high-dose intravenous
thiamine and simultaneously treat magnesium deficiency.
Alcoholics at risk of WE should on admission receive
immediate prophylactic therapy with parenteral thiamine
Thorarinsson BL, Olafsson E, Kjartansson O, Blöndal H.
Wernicke’s encephalopathy in chronic alcoholics. Icel Med J 2011:97:21-9
Key words: Wernicke's encephalopathy, Korsakoff's amnestic syndrome, Korsakoff's psychosis, thiamine, thiamine deficiency,
magnesium deficiency, malnutrition, alcoholism, alcohol dependency
Correspondence: Björn Logi Thorarinsson, bjornlth@hive.is
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English version on www.laeknabladid.is
Barst: 13. júní 2010, - samþykkt til birtingar: 30. nóvember 2010
Hagsmunatengsl: Engin
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