Læknablaðið - 15.01.2011, Blaðsíða 17

FRÆÐIGREINAR
RANNSÓKN
stuðla að eða draga úr ofnæmissjúkdómum hjá
börnum. Einnig fæst svar við því hvort algengi
fæðuofnæmis fer vaxandi hér á landi þegar
börnunum verður fylgt eftir til 24 mánaða aldurs
og samanburður fæst við fyrri rannsóknir.
Niðurstöður þessarar rannsóknar eru bæði
áhugaverðar fyrir ísland og í alþjóðlegu samhengi.
Ráðgert er að fylgja þessum börnum eftir næst
við sex ára aldur í áframhaldandi alþjóðlegu
samstarfi.
Þakkir
Þakkir eru færðar þeim fjölmörgu sem komu að
þessari rannsókn; Önnu Guðbjörgu Gunnars-
dóttur hjúkrunarfræðingi, öðrum starfsmönnum
EuroPrevall-rannsóknarinnar á Islandi og hjúkrun-
arfræðingum í mæðraeftirliti og fósturgrein-
ingardeildum. Einnig fá öll börnin og foreldrarnir
sem tóku þátt í rannsókninni þakkir. Að lokum
fá Rannsóknarsjóður íslenskra námsmanna,
vísindasjóður Landspítala og Evrópusambandið
(FOOD-CT-2005-514000) þakkir fyrir að styrkja
verkefnið.
Heimildir
1. Rona RJ, Keil T, Summers C, et al. The prevalence of food
allergy: A meta-analysis. J Allergy Clin Immunol 2007; 120:
638-46.
2. Hong X, Tsai HJ, Wang X. Genetics of food allergy. Curr Opin
Pediatr 2009; 21: 770-6.
3. van Wijk F, Knippels L. Initiating mechanisms of food
allergy: Oral tolerance versus allergic sensitization. Biomed
Pharmacother 2007; 61: 8-20.
4. Berg AV, Krámer U, Link E, et al. Impact of early feeding
on childhood eczema: Development after nutritional
intervention compared with the natural course - The
GINIplus study up to the age of 6 years. Clin Exp Allergy
2010; 40: 627-36.
5. Sicherer SH, Sampson HA. 9. Food allergy. J Allergy Clin
Immunol 2006; 117(SUPPL. 2):S470-S5+S89.
6. Host A, Halken S, Muraro A et al. Dietary prevention of
allergic diseases in infants and small children: Amendment
to previous published articles in Pediatric Allergy and
Immunology 2004, by an expert group set up by the Section
on Pediatrics, European Academy of Allergology and
Clinical Immunology. Pediatr Allergy Immunol 2008; 19:1-4.
7. Keil T, McBride D, Grimshaw K, et al. The multinational
birth cohort of EuroPrevall: background, aims and methods.
Allergy 2010; 65: 482-90.
8. Landlæknisembættið. Fæðingar á íslandi og fæðingartíðni
1995-2009. www.influensa.is/Heilbrigdistolfraedi/Faeding-
ar. 30. apríl 2010.
9. Gíslason D, Gíslason Þ, Blöndal Þ, Helgason H. Bráðaofnæmi
hjá 20-44 ára íslendingum. Læknablaðið 1995; 81: 606-12.
10. lóistjansson I, Ardal B, Jonsson JS, Sigurdsson JA, Foldevi
M, Bjorksten B. Adverse reactions to food and food allergy in
young children in Iceland and Sweden. Scand J Prim Health
Care 1999; 17: 30-4.
11. Venter C, Pereira B, Grundy J. et al. Incidence of parentally
reported and clinically diagnosed food hypersensitivity in
the first year of life. J Allergy Clin Immunol 2006; 117: 1118-
24.
12. Eiríksson H, Árdal B, Lúðvíksson BR, Sigfússon A,
Valdimarsson H, Haraldsson A. Ofnæmi og astmi hjá
íslenskum bömum. Læknablaðið 2000; 86:102-7.
13. Cantani A. The growing genetic links and the early onset of
atopic diseases in children stress the unique role of the atopic
march: a meta-analysis. J Investig Allergol Clin Immunol
1999; 9: 314-20.
14. Ludviksson BR, Eiriksson TH, Ardal B, Sigfusson A,
Valdimarsson H. Correlationbetween serum immunoglobulin
A concentrations and allergic manifestations in infants. J
Pediatrics 1992; 121: 23-7.
15. Osterballe M, Hansen TK, Mortz CG, Host A, Bindslev-
Jensen C. The prevalence of food hypersensitivity in an
unselected population of children and adults. Pediatr
Allergy Immunol 2005; 16: 567-73.
16. Östblom E, Wickman M, van Hage M, Lilja G. Reported
symptoms of food hypersensitivity and sensitization to
common foods in 4-year-old children. Acta Paediatr 2008; 97:
85-90.
17. Kvenshagen B, Halvorsen R, Jacobsen M. Is there an
increased frequency of food allergy in children delivered by
caesarean section compared to those delivered vaginally?
Acta Paediatr 2009; 98: 324-7.
18. Jedrychowski W, Galas A, Whyatt R, Perera F. The prenatal
use of antibiotics and the development of allergic disease in
one year old infants. A preliminary study. Int J Occup Med
Environ Health 2006; 19: 70-6.
19. Martel MJ, Rey E, Malo JL, et al. Determinants of the
incidence of childhood asthma: a two-stage case-control
study. Am J Epidemiol 2009; 169:195-205.
20. Grimshaw KE, Allen K, Edwards CA, et al. Infant feeding
and allergy prevention: a review of current knowledge and
recommendations. A EuroPrevall state of the art paper.
Allergy 2009; 64:1407-16.
21. Kumar R, Ouyang F, Story RE et al. Gestational diabetes,
atopic dermatitis, and allergen sensitization in early
childhood. J Allergy Clin Immunol 2009; 124:1031-8.
22. Sugiyama M, Arakawa H, Ozawa K, et al. Early-life risk
factors for occurrence of atopic dermatitis during the first
year. Pediatrics 2007; 119: e716-23.
23. Almqvist C, Pershagen G, Wickman M. Low socioeconomic
status as a risk factor for asthma, rhinitis and sensitization at
4 years in a birth cohort. Clin Exp Allergy 2005; 35: 612-8.
24. Chen CM, Tischer C, Schnappinger M, Heinrich J. The role of
cats and dogs in asthma and allergy-a systematic review. Int
J Hyg Environ Health 2010; 213:1-31.
25. Keski-Nisula L, Heinonen S, Remes S, Pekkanen J. Pre-
eclampsia, placental abruption and increased risk of atopic
sensitization in male adolescent offspring. Am J Reprod
Immunol 2009; 62: 293-300.
26. Oien T, Storro O, Johnsen R. Do early intake of fish and fish
oil protect against eczema and doctor-diagnosed asthma at 2
years of age? A cohort study. J Epidemiol Community Health
2010; 64:124-9.
27. Davidson R, Roberts SE, Wotton CJ, Goldacre MJ. Influence of
matemal and perinatal factors on subsequent hospitalisation
for asthma in children: evidence from the Oxford record
linkage study. BMC Pulm Med 2010; 10:14.
28. Barnes KC. Án update on the genetics of atopic dermatitis:
scratching the surface in 2009. J Allergy Clin Immunol 2010;
125:16-29 el-ll;quiz 30-1.
29. Pohlabeln H, Muhlenbruch K, Jacobs S, Bohmann H.
Frequency of allergic diseases in 2-year-old children in
relationship to parental history of allergy and breastfeeding.
J Investig Allergol Clin Immunol 2010; 20:195-200.
Niðurstöðurnar hafa verið kynntar á Rannsóknarráðstefnu Heilbrigðissviðs HÍ og á
Vísindi á vordögum og birst í Fylgiriti Læknablaðsins.
LÆKNAblaðið 2011/97 17