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Læknablaðið - 15.01.2011, Qupperneq 17

Læknablaðið - 15.01.2011, Qupperneq 17
FRÆÐIGREINAR RANNSÓKN stuðla að eða draga úr ofnæmissjúkdómum hjá börnum. Einnig fæst svar við því hvort algengi fæðuofnæmis fer vaxandi hér á landi þegar börnunum verður fylgt eftir til 24 mánaða aldurs og samanburður fæst við fyrri rannsóknir. Niðurstöður þessarar rannsóknar eru bæði áhugaverðar fyrir ísland og í alþjóðlegu samhengi. Ráðgert er að fylgja þessum börnum eftir næst við sex ára aldur í áframhaldandi alþjóðlegu samstarfi. Þakkir Þakkir eru færðar þeim fjölmörgu sem komu að þessari rannsókn; Önnu Guðbjörgu Gunnars- dóttur hjúkrunarfræðingi, öðrum starfsmönnum EuroPrevall-rannsóknarinnar á Islandi og hjúkrun- arfræðingum í mæðraeftirliti og fósturgrein- ingardeildum. Einnig fá öll börnin og foreldrarnir sem tóku þátt í rannsókninni þakkir. Að lokum fá Rannsóknarsjóður íslenskra námsmanna, vísindasjóður Landspítala og Evrópusambandið (FOOD-CT-2005-514000) þakkir fyrir að styrkja verkefnið. Heimildir 1. Rona RJ, Keil T, Summers C, et al. The prevalence of food allergy: A meta-analysis. J Allergy Clin Immunol 2007; 120: 638-46. 2. Hong X, Tsai HJ, Wang X. Genetics of food allergy. Curr Opin Pediatr 2009; 21: 770-6. 3. van Wijk F, Knippels L. Initiating mechanisms of food allergy: Oral tolerance versus allergic sensitization. Biomed Pharmacother 2007; 61: 8-20. 4. Berg AV, Krámer U, Link E, et al. Impact of early feeding on childhood eczema: Development after nutritional intervention compared with the natural course - The GINIplus study up to the age of 6 years. Clin Exp Allergy 2010; 40: 627-36. 5. Sicherer SH, Sampson HA. 9. Food allergy. J Allergy Clin Immunol 2006; 117(SUPPL. 2):S470-S5+S89. 6. Host A, Halken S, Muraro A et al. Dietary prevention of allergic diseases in infants and small children: Amendment to previous published articles in Pediatric Allergy and Immunology 2004, by an expert group set up by the Section on Pediatrics, European Academy of Allergology and Clinical Immunology. Pediatr Allergy Immunol 2008; 19:1-4. 7. Keil T, McBride D, Grimshaw K, et al. The multinational birth cohort of EuroPrevall: background, aims and methods. Allergy 2010; 65: 482-90. 8. Landlæknisembættið. Fæðingar á íslandi og fæðingartíðni 1995-2009. www.influensa.is/Heilbrigdistolfraedi/Faeding- ar. 30. apríl 2010. 9. Gíslason D, Gíslason Þ, Blöndal Þ, Helgason H. Bráðaofnæmi hjá 20-44 ára íslendingum. Læknablaðið 1995; 81: 606-12. 10. lóistjansson I, Ardal B, Jonsson JS, Sigurdsson JA, Foldevi M, Bjorksten B. Adverse reactions to food and food allergy in young children in Iceland and Sweden. Scand J Prim Health Care 1999; 17: 30-4. 11. Venter C, Pereira B, Grundy J. et al. Incidence of parentally reported and clinically diagnosed food hypersensitivity in the first year of life. J Allergy Clin Immunol 2006; 117: 1118- 24. 12. Eiríksson H, Árdal B, Lúðvíksson BR, Sigfússon A, Valdimarsson H, Haraldsson A. Ofnæmi og astmi hjá íslenskum bömum. Læknablaðið 2000; 86:102-7. 13. Cantani A. The growing genetic links and the early onset of atopic diseases in children stress the unique role of the atopic march: a meta-analysis. J Investig Allergol Clin Immunol 1999; 9: 314-20. 14. Ludviksson BR, Eiriksson TH, Ardal B, Sigfusson A, Valdimarsson H. Correlationbetween serum immunoglobulin A concentrations and allergic manifestations in infants. J Pediatrics 1992; 121: 23-7. 15. Osterballe M, Hansen TK, Mortz CG, Host A, Bindslev- Jensen C. The prevalence of food hypersensitivity in an unselected population of children and adults. Pediatr Allergy Immunol 2005; 16: 567-73. 16. Östblom E, Wickman M, van Hage M, Lilja G. Reported symptoms of food hypersensitivity and sensitization to common foods in 4-year-old children. Acta Paediatr 2008; 97: 85-90. 17. Kvenshagen B, Halvorsen R, Jacobsen M. Is there an increased frequency of food allergy in children delivered by caesarean section compared to those delivered vaginally? Acta Paediatr 2009; 98: 324-7. 18. Jedrychowski W, Galas A, Whyatt R, Perera F. The prenatal use of antibiotics and the development of allergic disease in one year old infants. A preliminary study. Int J Occup Med Environ Health 2006; 19: 70-6. 19. Martel MJ, Rey E, Malo JL, et al. Determinants of the incidence of childhood asthma: a two-stage case-control study. Am J Epidemiol 2009; 169:195-205. 20. Grimshaw KE, Allen K, Edwards CA, et al. Infant feeding and allergy prevention: a review of current knowledge and recommendations. A EuroPrevall state of the art paper. Allergy 2009; 64:1407-16. 21. Kumar R, Ouyang F, Story RE et al. Gestational diabetes, atopic dermatitis, and allergen sensitization in early childhood. J Allergy Clin Immunol 2009; 124:1031-8. 22. Sugiyama M, Arakawa H, Ozawa K, et al. Early-life risk factors for occurrence of atopic dermatitis during the first year. Pediatrics 2007; 119: e716-23. 23. Almqvist C, Pershagen G, Wickman M. Low socioeconomic status as a risk factor for asthma, rhinitis and sensitization at 4 years in a birth cohort. Clin Exp Allergy 2005; 35: 612-8. 24. Chen CM, Tischer C, Schnappinger M, Heinrich J. The role of cats and dogs in asthma and allergy-a systematic review. Int J Hyg Environ Health 2010; 213:1-31. 25. Keski-Nisula L, Heinonen S, Remes S, Pekkanen J. Pre- eclampsia, placental abruption and increased risk of atopic sensitization in male adolescent offspring. Am J Reprod Immunol 2009; 62: 293-300. 26. Oien T, Storro O, Johnsen R. Do early intake of fish and fish oil protect against eczema and doctor-diagnosed asthma at 2 years of age? A cohort study. J Epidemiol Community Health 2010; 64:124-9. 27. Davidson R, Roberts SE, Wotton CJ, Goldacre MJ. Influence of matemal and perinatal factors on subsequent hospitalisation for asthma in children: evidence from the Oxford record linkage study. BMC Pulm Med 2010; 10:14. 28. Barnes KC. Án update on the genetics of atopic dermatitis: scratching the surface in 2009. J Allergy Clin Immunol 2010; 125:16-29 el-ll;quiz 30-1. 29. Pohlabeln H, Muhlenbruch K, Jacobs S, Bohmann H. Frequency of allergic diseases in 2-year-old children in relationship to parental history of allergy and breastfeeding. J Investig Allergol Clin Immunol 2010; 20:195-200. Niðurstöðurnar hafa verið kynntar á Rannsóknarráðstefnu Heilbrigðissviðs HÍ og á Vísindi á vordögum og birst í Fylgiriti Læknablaðsins. LÆKNAblaðið 2011/97 17
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