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Læknablaðið - 15.09.2011, Síða 15

Læknablaðið - 15.09.2011, Síða 15
RANNSÓKN Heimildir 1. Burr ML, Butland BK, King S, Vaughan-Williams E. Changes in asthma prevalence: two surveys 15 years apart. Arch Dis Child 1989; 64:1452-6. 2. Ninan TK, Russell G. Respiratory symptoms and atopy in Aberdeen schoolchildren: evidence from two surveys 25 years apart. BMJ 1992; 304: 873-5. 3. Wieringa MH, Weyler JJ, Nelen VJ, et al. Prevalence of respiratory symptoms: marked differences within a small geographical area. Int J Epidemiol 1998; 27: 630-5. 4. Comtois P. The experimental research of Charles H. Blackley. Aerobiologia 1995; 11: 63-8. 5. Riedler J, Eder W, Oberfeld G, Schreuer M. Austrian children living on a farm have less hay fever, asthma and allergic sensitization. Clin Exper Allergy 2000; 30:194-200. 6. Bjamadóttir E, Gíslason D, Gíslason Þ. Algengi bráða- ofnæmis og astma meðal íslenskra læknanema. Lækna- blaðið 2001; 87: 621-4. 7. Weiland SK, von Mutius E, Hirsch T, et al. Prevalence of respiratory and atopic disorders among children in the East and West of Germany five years after unification. Eur Respir J 1999; 14: 862-70. 8. Bumey PG, Malmberg E, Chinn S, Jarvis D, Luczynska C, Lai E. The distribution of total and specific semm IgE in the European Community Respiratory Health Survey. J Allergy Clin Immunol 1997; 99:314-22. 9. Chinn S, Bumey P, Sunyer J, Jarvis D, Luczynska C. Sensitization to individual allergens and bronchial responsiveness in European Community Respiratory Health Study. Eur Respir J 1999; 14: 876-84. 10. Gíslason Þ, Gíslason D, Blöndal Þ. Astmi og öndunarfæraeinkenni meðal 20-44 ára íslendinga. Læknablaðið 1997; 83:211-6. 11. Kummeling I, Mills EN, Clausen M, et al. The EuroPrevall surveys on the prevalence of food allergies in children and adults: background and study methodology. Allergy 2009; 64:1493-7. 12. Gíslason Þ, Gíslason D, Blöndal Þ, Helgason H, Rafnsson V. Öndunarfæraeinkenni íslendinga á aldrinum 20-44 ára. Læknablaðið 1993; 79:343-7. 13. Gíslason D, Gíslason Þ, Blöndal T, Helgason H. Bráðaofnæmi hjá 20-44 ára íslendingum. Læknablaðið 1995; 81: 606-12. 14. Clausen M, Kristjánsson S, Haraldsson A, Björkstén B. High prevalence of allergic diseases and sensitization in a low allergen country. Acta Paediatr 2008; 97:1216-20. 15. Zollner IK, Weiland SK, Piechotowski I, et al. No increase in the prevalence of asthma, allergies, and atopic sensitization among children in Germany: 1992-2001. Thorax 2005; 60: 545-48. 16. Gíslason D, Gíslason Þ, Blöndal T, Helgason H. Atopy, Hyperresponsiveness and Asthma in Icelandic Urban Population 20-44 Years of Age. Allergy (suppl. nr. 32) 1996; 51:61. 17. Ring J, Krámer U, Scháfer T, Behrendt H. Why are allergies increasing? Curr Opin Immunol 2001; 13: 701-8. 18. Strachan DP. Hay-Fever, Hygiene, and Household Size. BMJ 1989; 299:1259-60. 19. von Mutius E, Vericelli D. Farm living: effect on childhood asthma and allergy. Nat Rev Immunol 2010; 10: 861-8. 20. Þorgeirsdóttir H, Steingrímsdóttir L, Ólafsson Ö, Guðnason V. Þróun ofþyngdar og offitu meðal 45-64 ára Reykvíkinga á árunum 1975-1994. Læknablaðið 2005; 91: 115-21. 21. Gunnbjömsdóttir MI, Amenaas E, Gíslason Þ, et al. Obesity and noctumal gastro-oesophageal reflux are related to onset of asthma and respiratory symptoms. Eur Respir J 2004; 24:116-21. 22. Ólafsdóttir IS, Gíslason T, Þjóðleifsson B, et al. C-reactive protein is elevated in non-allergic but not allergic asthma - a multicentre epidemiological study. Thorax 2005; 60: 451-4. 23. Gislason T, Janson C, Vermeire P, et al. Reported gastro- oesophageal reflux during sleep and respiratory symp- toms. A population study of young adults in three European Countries. Chest 2002; 121:158-63. 24. Laerum BN, Wentzel-Larsen T, Gulsvik A, et al. Rela- tionship of fish and cod oil intake with adult asthma. Clin Exp Allergy 2007; 37:1616-23. 25. Hallsdóttir M. - www.ni.is/grodur/frjomaelingar/ samantekt - júní 2011. ENGLISH SUMMARY Prevalence of respiratory symptoms and use of asthma drugs are increasing among young adult lcelanders Sigurkarlsson S, Clausen M, Gíslason T, Gíslason D Introduction: In the year 1990 the European Community Respiratory Health Survey I (ECRHS I) demonstrated that the prevalence of these diseases was lowest in lceland (www.ecrhs.org). In order to compare the prevalence of respiratory symptoms in Reykjavik over time, a new identical cross- sectional study was performed seventeen years later. Material and methods: Both cohorts, were in the age group 20-44 years and randomly selected from the population in Reykjavik and suburbs. Both answered questionnaires about respiratory symptoms, nasal allergy and use of anti-asthmatic drugs. The second cohort was part of the EuroPrevall study (www.europrevall.org) performed in 2007. Results: Response rate was lower in 2007 (999 or 43.2%) than in 1990 (2.903 or 80.6%).The prevalence of attacks of asthma increased over time from 2.2% to 6.7% (p<0.0001), use of anti-asthmatic drugs increased from 2.4% to 7.2% (p<0.0001) and nasal allergy symptoms from 17.8% to 29.3% (p< 0.0001). There was an increase of all respiratory symptoms except wheezing or whistling, where the prevalence dropped from 18.0% to 14.4% (p<0.01). In the year 2007 women had more often been woken by attacks of coughing (p<0.0001), had more often attacks of asthma (p<0.05) and were more likely to use anti-asthmatic drugs (p<0.05) than men. Attacks of asthma and the use of anti-asthmatic drugs were more common among the younger age group in the year 2007. That was not seen in the year 1990. Conclusion: This study provides evidence of an increase in respiratory symptoms and use of anti-asthmatic drugs over a period of 17 years from 1990 among young adult lcelanders. Key words: Prevalence, asthma, ECRHS. Correspondence: Davið Gíslason, davidgis@simnet.is LÆKNAblaðið 2011/97 467

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