Náttúrufræðingurinn - 2013, Page 93

93
Tímarit Hins íslenska náttúrufræðifélags
20. Hendrie, H.C., Murrell, J., Gao, S.J., Unverzagt, F.W., Ogunniyi, A. &
Hall, K.S. 2006. International studies in dementia with particular
emphasis on populations of African origin. Alzheimer Disease and
Associated Disorders 20(3). S42–S6.
21. Bucciantini, M., Giannoni, E., Chiti, F., Baroni, F., Formigli, L., Zurdo, J.
o.fl. 2002. Inherent toxicity of aggregates implies a common mechanism
for protein misfolding diseases. Nature 416 (6880). 507–511.
22. Ravikumar, B., Sarkar, S., Davies, J.E., Futter, M., Garcia-Arencibia, M.,
Green-Thompson, Z.W. o.fl. 2010. Regulation of mammalian autophagy in
physiology and pathophysiology. Physiological Reviews 90 (4). 1383–1435.
23. Rabinowitz, J.D. & White, E. 2010. Autophagy and metabolism. Science
330 (6009). 1344–1348.
24. Mijaljica, D., Prescott, M. & Devenish, R.J. 2010. Autophagy in disease.
Methods in Molecular Biology 648. 79–92.
25. Arias, E. & Cuervo, A.M. 2011. Chaperone-mediated autophagy in protein
quality control. Current Opinion in Cell Biology 23(2). 184–189.
26. Cherra, S.J., Dagda, R.K. & Chu, C.T. 2010. Review: autophagy and neu-
rodegeneration: survival at a cost? Neuropathology and Applied Neuro-
biology 36 (2). 125–132.
27. Barnett, A. & Brewer, G.J. 2011. Autophagy in aging and Alzheimer's
disease: pathologic or protective? Journal of Alzheimer's Disease 25(3).
385–394.
28. Quan, S., Koldewey, P., Tapley, T., Kirsch, N., Ruane, K.M., Pfizenmaier,
J. o.fl. 2011. Genetic selection designed to stabilize proteins uncovers a
chaperone called Spy. Nature Structural & Molecular Biology 18 (3).
262–U41.
29. Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-
Migishima, R. o.fl. 2006. Suppression of basal autophagy in neural cells
causes neurodegenerative disease in mice. Nature 441 (7095). 885–889.
30. Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Tanida, I. o.fl.
2006. Loss of autophagy in the central nervous system causes neurode-
generation in mice. Nature 441 (7095). 880–884.
31. Kegel, K.B., Kim, M., Sapp, E., McIntyre, C., Castano, J.G., Aronin, N.
o.fl. 2000. Huntingtin expression stimulates endosomal-lysosomal
activity, endosome tubulation, and autophagy. The Journal of Neuro-
science 20(19). 7268–7278.
32. Cataldo, A.M., Barnett, J.L., Berman, S.A., Li, J.H., Quarless, S., Bursztajn,
S. o.fl. 1995. Gene-Expression and Cellular Content of Cathepsin-D in
Alzheimers-Disease Brain - Evidence for Early up-Regulation of the
Endosomal Lysosomal System. Neuron 14(3). 671–680.
33. Tsujimoto, Y. & Shimizu, S. 2005. Another way to die: autophagic pro-
grammed cell death. Cell Death Differ 12. 1528–1534.
34. Madeo, F., Eisenberg, T. & Kroemer, G. 2009. Autophagy for the avoid-
ance of neurodegeneration. Genes & Development 23(19). 2253–2259.
35. Hetz, C., Thielen, P., Matus, S., Nassif, M., Court, F. & Kiffin, R. o.fl. 2009.
XBP-1 deficiency in the nervous system protects against amyotrophic
lateral sclerosis by increasing autophagy. Genes & Development 23(19).
2294–2306.
36. Caccamo, A., Majumder, S., Richardson, A., Strong, R. & Oddo, S. 2010.
Molecular Interplay between Mammalian Target of Rapamycin (mTOR),
Amyloid-beta, and Tau: effects on cognitive impairments. The Journal of
Biological Chemistry 285(17). 13107–13120.
37. Ling, D.J., Song, H.J., Garza, D., Neufeld, T.P., Salvaterra, P.M. 2009.
Abeta42-Induced Neurodegeneration via an Age-Dependent Autophag-
ic-Lysosomal Injury in Drosophila. PLoS One 4 (1).
38. Sarkar, S., Perlstein, E.O., Imarisio, S., Pineau, S., Cordenier, A., Maglathlin,
R.L. o.fl. 2007. Small molecules enhance autophagy and reduce toxicity in
Huntington's disease models. Nature Chemical Biology 3 (6). 331–338.
39. Bove, J., Martinez-Vicente, M. & Vila, M. 2011. Fighting neurodegenera-
tion with rapamycin: mechanistic insights. Nature Reviews Neurosci-
ence 12(8). 437–452.
40. Fulceri, F., Ferrucci, M., Lazzeri, G., Paparelli, S., Bartalucci, A., Tambur-
ini, I. o.fl. 2011. Autophagy activation in glutamate-induced motor neu-
ron loss. Archives Italiennes de Biologie 149(1). 101–111.
41. Fornai, F., Siciliano, G., Manca, M.L., Murri, L., Paparelli, A. & Ruggieri, S.
2008. Lithium in ALS: from the bench to the bedside. Amyotrophic
Lateral Sclerosis 9(2). 123–124.
42. Fornai, F., Longone, P., Cafaro, L., Kastsiuchenka, O., Ferrucci, M., Manca,
M.L. o.fl. 2008. Lithium delays progression of amyotrophic lateral
sclerosis. Proceedings of the National Academy of Sciences of the
United 105(6). 2052–2057.
43. Yeh, H.L. & Tsai, S.J. 2008. Lithium may be useful in the prevention
of Alzheimer's disease in individuals at risk of presenile familial
Alzheimer's disease. Medical Hypotheses 71(6). 948–951.
44. Margrét Bessadóttir, Már Egilsson, Eydís Einarsdóttir, Íris H.
Magnúsdóttir, Margrét H. Ögmundsdóttir, Sesselja Ómarsdóttir &
Helga M. Ögmundsdóttir 2012. Proton-shuttling lichen compound
usnic acid affects mitochondrial and lysosomal function in cancer cells.
PloS 7(12). e51296.
45. Gillette-Guyonnet, S. & Vellasa, B. 2008. Caloric restriction and brain
function. Curr. Opin. Clinical Nutrition 11(6). 686–692.
46. Mattison, J.A., Roth, G.S., Beasley, T.M., Tilmont, E.M., Handy, A.M.,
Herbert, R.L. o.fl. 2012. Impact of caloric restriction on health and sur-
vival in rhesus monkeys from the NIA study. Nature 489. 318-321.
47. Mouton, P.R., Chachich, M.E., Quigley, C., Spangler, E. & Ingram, D.K.
2009. Caloric restriction attenuates amyloid deposition in middle-aged
dtg APP/PS1 mice. Neuroscience Letters 464(3). 184–187.
48. Alirezaei, M., Kemball, C.C. & Whitton, J.L. 2011. Autophagy, inflamma-
tion and neurodegenerative disease. European Journal of Neuroscience
33(2). 197–204.
49. Alirezaei, M., Kemball, C.C., Flynn, C.T., Wood, M.R., Whitton, J.L. &
Kiosses, W.B. 2010. Short-term fasting induces profound neuronal
autophagy. Autophagy 6(6). 702–710.
50. Madorsky, I., Opalach, K., Waber, A., Verrier, J.D., Solmo, C., Foster, T. o.fl.
2009. Intermittent fasting alleviates the neuropathic phenotype in a
mouse model of Charcot-Marie-Tooth disease. Neurobiology of Disease
34 (1). 146–154.
51. Thayer, Z.M. & Kuzawa, C.W. 2011. Biological memories of past environ-
ments Epigenetic pathways to health disparities. Epigenetics 6(7). 798–803.
52. Wang, J., Ho, L., Qin, W.P., Rocher, A.B., Seror, I. & Humala, N. o.fl. 2005.
Caloric restriction attenuates beta-amyloid neuropathology in a mouse
model of Alzheimer's disease. The Faseb Journal 19(6). 659–661.
53. Qin, W.P., Chachich, M., Lane, M., Roth, G., Bryant, M., de Cabo, R. o.fl.
2006. Calorie restriction attenuates Alzheimer's disease type brain amy-
loidosis in Squirrel monkeys (Saimiri sciureus). Journal of Alzheimer's
Disease 10 (4). 417–422.
54. Hamadeh, M.J., Rodriguez, M.C., Kaczor, J.J. & Tarnopolsky, M.A. 2005.
Caloric restriction transiently improves motor performance but hastens
clinical onset of disease in the Cu/Zn-superoxide dismutase mutant
G93A mouse. Muscle and Nerve 31 (2). 214–220.
um höfundinn
Pétur Henry Petersen (f. 1969) lauk B.S.- og M.S.-prófi
í líffræði frá Háskóla Íslands árin 1992 og 1996 og
doktorsprófi frá Yale háskóla 2004.
Póst- og netfang höfundar/Author’s address
Pétur Henry Petersen
Rannsóknastofa í Taugalíffræði
Lífvísindasetur Háskóla Íslands, Læknadeild
Vatnsmýrarvegi 16
IS-101 Reykjavík
phenry@hi.is