Læknablaðið - 01.06.2018, Blaðsíða 15
LÆKNAblaðið 2018/104 287
R A N N S Ó K N
1. Mourani S, Dobbs SM, Genta RM, Tandon AK, Yoffe B.
Hepatitis A Virus-associated Cholecystitis. Ann Intern
Med 1994; 120: 398-400.
2. Davis TV, Keeffe EB. Acute pancreatitis associated with
acute hepatitis A. Am J Gastroenterol 1992; 87: 1648-50.
3. Heilbrigðisskýrslur. Landlæknisembættið 1900-1979.
4. Briem H, Weiland O, Fridriksson I, Berg R. Prevalence of
antibody to hepatitis A in Iceland in relation to age, sex
and number of notified cases of hepatitis. Am J Epidemiol
1982; 116: 451-5.
5. Briem H. Declining prevalence of hepatitis A virus infect-
ion in Iceland. Scand J Infect Dis 1991; 23: 135-8.
6. Högnadottir H, Löve A. Greining lifrarbólguveiru A.
Læknablaðið 1993; 79: 223-6.
7. Farsóttaskýrslur sóttvarnalæknis-tilkynningarskyldir
sjúkdómar 1997-2016. Embætti landlæknis. landlaeknir.
is/smit-og-sottvarnir/smitsjukdomar/tilkynningarskyldir-
sjukdomar/ - nóvember 2017.
8. Kristinsdóttir H, Löve A, Björnsson ES. Lifrarbólga A á
Íslandi. Læknablaðið 2018; 104: 127-31.
9. Hepatitis A outbreak in the EU/EEA mostly affecting men
who have sex with men. Rapid risk assessment. ECDC.
Third update, 28 June 2017.
10. landlaeknir.is/um-embaettid/frettir/frett/item32603/
Lifrarbolgu-A-faraldur-i-Evropu - nóvember 2017
11. Briem H, Safary A. Immunogenicity and Safety in Adults
of Hepatitis A Virus Vaccine Administered as a Single
Dose with a Booster 6 Months later. J Med Virol 1994; 44:
443-5.
12. Mohammed RA, Ghadban W, Mohammed O. Acute
acalculus cholecystitis induced by hepatitis B virus infect-
ion. Case Reports Hepatol 2012: 132345.
13. Giorgio A, Francica G, Amorosos P, Fico P, de Stefano G,
Pierri P, et al. Morphologic and motility changes of the
gallbladder in response to acute liver injury. A prospective
real-time sonographic study in 255 patients with acute
viral hepatitis. J Ultrasound Med 1989; 8: 499-506.
14. Maudgal DP, Wansbrough-Jones MH, Joseph AE.
Gallbladder abnormalities in acute infectious hepatitis. A
prospective study. Dig Dis Sci 1984; 29: 257-60.
15. Cuk P, Iqbal M, Lykke J. Perforated acute acalculus cho-
lecystitis caused by hepatitis A. Ugeskr Læger 2014; 176:
V12130701.
16. Black MM, Mann NP. Gangrenous cholecystitis due to
hepatitis A infection. J Trop Med Hyg 1992; 95: 73-4.
17. Ozaras R, Mert A, Yilmaz MH, Celik AD, Tabak F, Bilir
M, et al. Acute viral cholecystitis due to hepatitis A virus
infection. J Clin Gastroenterol 2003; 37: 79-81.
18. Souza LJ, Braga LC, Rocha Nde S, Tavares RR. Acute
acalculus cholecystitis in a teenager with hepatitis A virus
infection – a case report. Braz J Infect Dis 2009; 13: 74-6.
19. Kaya S, Eskazan AE, Ay N, Baysal B, Bahadir MV, Onur A,
et al. Acute Acalculus Cholecystitis due to Viral Hepatitis
A. Case Rep Infect Dis 2013: 407182.
20. Haffar S, Bazerbachi F, Prokop L, Watt KD, Murad MH,
Chari ST. Frequency and prognosis of acute pancreatitis
associated with fulminant or non-fulminant acute hepatit-
is A: A systematic review. Pancreatology 2017; 17: 166-75.
Sif Ormarsdóttir1
Páll Helgi Möller1,2
Alma Rut Óskarsdóttir2
Pétur Hannesson1
Arthur Löve1
Haraldur Briem3
Aim
The incidence of hepatitis A (HAV) in Iceland is low with
about one case per year in the last decades. Since 2016,
there has been an ongoing outbreak of HAV in men who
have sex with men (MSM). The aim of this study was to
inves tigate whether cases diagnosed in Iceland during 2017
had any link to the HAV outbreak in Europe.
Methods
All cases of HAV in Iceland during 2017 were reviewed retro-
spectively.
Results
Four of five cases diagnosed during 2017 were MSM and
one was a female. Three cases presented the same week in
the summer 2017. The age of the patients was between 25
and 39 years. All the male patients had had sex with men
from Europe and/or had travelled to Europe prior to admis-
sion. All cases had typical signs and symptoms of HAV
infection and in all cases recent infection was confirmed
by positive serology and exclusion of other causes of acute
hepatitis. Four of five patients had radiological signs of
changes in the gallbladder with thickening of the wall and
oedema and one underwent later an elective cholecystect-
omy.
Conclusion
The outbreak of HAV in MSM Europe reached Iceland in the
summer 2017, emphasizing the importance of vaccination
in this risk group as recommended by the Icelandic Health
Authorities. The review of these cases indicate that changes
such as thickening of the gallbladder wall without gallstones
in patients with HAV are common. It is important to discrimi-
nate patients with these changes associated with HAV from
patients with acute acalculus cholecystitis.
European outbreak of Hepatitis A in Iceland in 2017.
Common radiological changes of the gallbladder
ENGLISH SUMMARY
Heimildir
Barst til blaðsins 8. mars 2018, samþykkt til birtingar 16. maí 2018.
1Landspitali, University Hospital of Iceland, 2University of Iceland, Faculty of Medicine, 3Directorate of Health.
Key words: Viral hepatitis A, European outbreak, men who have sex with men, acalculus cholecystitis.
Correspondence: Sif Ormarsdóttir, sifor@landspitali.is