Læknablaðið - 15.01.1991, Síða 15

LÆKNABLAÐIÐ
7
Table 6. Prevalence of iron deficiency in non-anemic and anemic subjects.
Subgroup No evidence for iron deficiency S-TIBC saturation <16% S-Ferritin <12 /ig/L Definite iron deficiency
Group A urban males (n=479) Anemic Non-anemic (1.0%) (94.5%) (0.6%) (3.3%) (0.0%) (0.4%) (0.2%) (0.0%)
Group A rural males (n=446) Anemic Non-anemic (0.9%) (95.5%) (0.0%) (3.4%) (0.0%) (0.2%) (0.0%) (0.0%)
Group A urban females (n=535) Anemic Non-anemic (4.1%) (83.6%) (1.3%) (8.4%) (0.2%) (0.9%) (1.3%) (0.2%)
Group A rural females (n=427) Anemic Non-anemic (1.2%) (92.0%) (0.7%) (5.9%) (0.0%) (0.0%) (0.0%) (0.2%)
Group B males (n=372) Anemic Non-anemic (1-1%) (90.0%) (0.3%) (6.2%) (0.0%) (1.9%) (0.0%) (0.5%)
Group B females (n=333) Anemic Non-anemic (3.6%) (70.6%) (1.8%) (10.5%) (1.8%) (3.9%) (3.3%) (4.5%)
Anemia is defined as B-Hemoglobin<130g/L in males and <120 g/L in females.
»No evidence for iron deficiency« column includes subjects with S-TIBC>16% and S-Ferritin>12 fig/L.
»S-TIBC saturation <16%« column includes subjects with S-TIBC<16% but S-Ferritin>12 /xg/L.
»S-Ferritin<12/ig/L« column includes subjects with S-Ferritin <12/ig/L but S-TIBC saturation >16%.
»Definite iron deficiency« column includes subjects with S-TIBC saturation <16% and S-Ferritin<12/ig/L.
Table 7. Number and percentage of patients with iron overload in group A.
Iron overload on Iron overload upon
initial screening repeated testing
Subgroup Number Percentage Number Percentage
Urban males (n=479) .......................... 6 (1.25%) 3 (0.63%)
Urban females (n=535)......................... 4 (0.75%) 2 (0.37%)
Rural males (n=446)........................... 5 (1.12%) 2 (0.45%)
Rural females (n=427) ........................ 1 (0.23%) 0 (0.0%)
Criteria for iron overload were S-TIBC saturation >50% and S-Ferritin >500 /rg/L or S-TiBC saturation >60% and S-Ferritin >380 //g/L in males
and >220 /ig/L in females. The 15 individuals with iron overload in the initial study were retested at a different time and the number and percentage
of patients repeatedly fulfilling the aforementioned criteria are denoted in the second half of the table.
Table 8. Characteristics of seven patients with iron overload in group A.
S-TIBC Serum Liver Iron
Case Age saturation S-Ferritin iron stores Clinical
no. years Sex % /zmol/L grade g remarks HLA class
1 ....................... 68 F (82) 900 3 3.3 Symptomless A3, B7, B18
2 ....................... 63 M (85) 1050 4 3.8 Gastrectomized A3, B7, A25, B18
3 ....................... 52 M (77) 740 3 3.8 Lassitude A1, B15, A2, B17
4 ....................... 50 M (84) 800 3 2.7 Gastrectomized Aw19, B7, A25, B18
5 ...................... 54 F (89) 350 3 - Symptomless ------------
6 ...................... 62 M (54) 1080 2 - Symptomless ------------
7 ...................... 57 M (70) 615 3 - Alcoholic ----
The S-TIBC saturation and S-Ferritin values are averages from three independent measurements. Liver iron grade was estimated by the method of
Scheuer (23). Iron stores were calculated after serial phlebotomy with a 4 mg/day correction factor for iron absorption. Patients no. 5 to 7 did not
undergo serial phlebotomy by the investigators.
Sjö einstaklingar uppfylltu skilmerki
jámofhleðslu við endurteknar mælingar
(tafla 7) og voru því rannsakaðir nánar (tafla
8). Fyrsti sjúklingurinn var einkennalaus,
68 ára gömul kona með sögu um eðlilegar
tíðablæðingar og hafði fætt tvö böm. Einn