Læknablaðið - 15.04.2010, Blaðsíða 25

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Factors predictive of survival after lobectomy for non-small
cell lung cancer in lceland during 1999-2008
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Oskarsdottir GN, SkuladoWr R, Thorsteinsson H, Isaksson HJ, Jonsson, Gudbjartsson T.
Factors predictive of survival after lobectomy for non-small cell lung cancer in lceland during 1999-2008.
lcelMed J 2010; 96:251-7.
Key words: Lung cancer, lobectomy, survival, prognostic factors, multivariate anatysis.
Correspondence: Tómas Guðbjartsson, tomasgud@landspitali.is
Objective: To study the impact of TNM stage and various
preoperative functional parameters on survival in patients
who underwent lobectomy for non-small cell lung cancer
(NSCLC) in lceland from 1999 to 2008.
Materials and methods: Retrospective study including
213 patients (mean age 66.9 yrs, equal male/female ratio)
that underwent lobectomy for NSCLC. Tumors were staged
by the TNM staging system, survival was estimated by the
Kaplan-Meier method and prognostic factors of survival
studied using the Cox proportional hazards regression
model.
Results: Survival at 1 year was 82.7% and 45.1 % at
5 years. Operative mortality at 30 days was 0%. Most
tumors were found to be in stage I (59.6%) or stage II
(17.8%) and 7% were stage IIIA, whereas 14.6% were
in stage IIIB or IV. Using multivariate analysis; advancing
stage, increasing tumor size, reduced lung function and
history of arrhythmia, predicted worse survival, whereas
adenocarcinoma histology was a positive prognostic factor
(HR 0.5, p=0.002) when compared to other histological
types.
Conclusions: Survival for patients undergoing lobectomy
for operable non-small cell lung cancer in lceland is
comparable with other studies. Advanced stage, tumor
size, reduced lung function and arrhythmia were negative
predictors of survival, but in contrast to many but not
all studies adenocarcinoma histology predicted a better
prognosis compared to other tumor types.
Barst: 4. október 2009, - samþykkt til birtingar: 25. janúar 2010
Hagsmunatengsl: Engin
LÆKNAblaðið 2010/96 257
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