Læknablaðið - 01.03.2014, Page 23

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ENGLISH SUMMARY
introduction: Amniocentesis and chorionic villus sampling (CVS) are
methods for fetal chromosomal diagnosis. Pregnant women aged ≥35
years have been offered amniocentesis in Iceland for over 35 years. The
main testing indication was maternal age until 1998, when universal
early screening was introduced. We examined outcome and fetal loss
following amniocentesis and CVS in singleton and twin pregnancies, age
distribution changes, reasons for the procedures and fetal karyotype
diagnoses.
Material and methods: Retrospective quantitative study on women
who had amniocentesis and CVS (n=2323) in the Prenatal Diagnosis
Unit at Landspitali University Hospital during 1998-2007. Unit files and
individual case and maternity records were used to retrieve information
on the indications and on maternal age, type of procedure, outome of
pregnancy, and the fetal karyotype.
Results: The number of procedures was substantially reduced from
over 500 to just over 100 per year, with a proportional shift to CVS.
Procedure-related fetal loss was 22/2323 (0.9%), with no significant
difference between amniocentesis (0.8%) and CVS (1.3%). The diffe-
rence decreased in the latter half of the study period to 0.7% and 0.8%,
respectively. Age-related reasons decreased from 81.2% to 30.8%.
Conclusion: The fetal loss incidence rates indicated that amniocentesis
and CVS have the same safety level as elsewhere. Complications were
uncommon. With CVS fetal screening was moved to an earlier time in
pregnancy. Early screening has changed the maternal age profile and is
available to all women on request. The information obtained can be used
to improve service information.
Fetal loss after amniocentesis and chorionic villus sampling in iceland
Kristin Rut Haraldsdottir, Helga Gottfredsdottir, Reynir Tomas Geirsson
keywords: Amniocentesis, chorion villus sampling, miscarriage, fetal loss, singelton pregnancy, twins.
Correspondence: Kristín Rut Haraldsdóttir, krruthar@landspitali.is
1Faculty of Nursing, Department of Midwifery, University of Iceland, 2Women´s Clinic, Landspitali University Hospital, 3Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
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