Læknablaðið

Árgangur

Læknablaðið - 01.06.2016, Blaðsíða 22

Læknablaðið - 01.06.2016, Blaðsíða 22
282 LÆKNAblaðið 2016/102 Heimildir 1. Kristjánsdóttir H, Kristinsdóttir JD, Aradóttir AB, Hauksson A, Gottfreðsdóttir H, Reynisson R, et al. Meðgönguvernd heilbrigðra kvenna í eðlilegri meðgöngu. Klínískar leiðbeiningar. Landlæknisembættið 2010. land- laeknir.is/servlet/file/store93/item2548/4407.pdf - sept- ember 2015. 2. Haraldsdóttir KR, Gottfreðsdóttir H, Geirsson RT. Fósturlát í kjölfar legvatnsástungu og fylgjusýnitöku á Íslandi. Læknablaðið 2014; 100: 147-51. 3. Tabor A, Alfirevic Z. Update on procedure-related risks for prenatal 4. diagnosis techniques. Fetal Diagn Ther 2010; 27: 1-7. 5. Hill M, Fisher J, Chitty LS, Morris S. Women´s and health professionals preferences for prenatal tests for Down syndrome: a discrete choice experiment to contrast non- invasive prenatal diagnosis with current invasive tests. Genet Med 2012; 14: 905-13. 6. Lo YMD, Corbetta N, Chamberlain PF, Rai V, Sargent IL, Redman CWG, et al. Presence of fetal DNA in maternal plasma and serum. Lancet 1997; 350: 485-7. 7. Ashoor G, Syngelaki A, Wagner M, Birdir C, Nicolaides, KH. Chromosome-selective sequencing of maternal plasma cell–free DNA for first-trimester detection of trisomy 21 and trisomy 18. Am J Obstet Gynecol 2012; 206: 322.e1-5. 8. Bianchi DW, Platt LD, Goldberg JD, Abuhamad AZ, Sehnert AJ, Rava RP. Genome-wide fetal aneuploidy detection by maternal plasma DNA sequencing. Obstet Gynecol 2012; 119: 890-901. 9. Gil M, Quezada M, Revello R, Akolekar R, Nicolaides K. Analysis of cell-free DNA in maternal blood in screening for fetal aneuploidies: updated meta-analysis. Ultrasound Obstet Gynecol 2015; 45: 249-66. 10. Zhou Q, Pan L, Chen S, Chen F, Hwang R, Yang X, et al. Clinical application of non-invasive prenatal testing for the detection of trisomies 21, 18, and 13: a hospital experience. Prenat Diagn 2014; 34: 1061-5. 11. Allyse M, Minear M, Berson E, Sridhar S, Rote M, Hung A, et al. Non-invasive prenatal testing: a review of international implementation and challenges. Int J Womens Health 2015; 7: 113-26. 12. Lewis C, Hill M, Chitty L. Non-invasive prenatal diagnosis for single gene disorders: experience of patients. Clin Genet 2014; 85: 336-42. 13. Tischler R, Hudgins L, Blumenfeld YJ, Greely HT, Ormond, KE. Noninvasive prenatal diagnosis: pregnant women´s interest and expected uptake. Prenat Diagn 2011; 31: 1292-9. 14. Verweij EJ, Oepkes D, de Vries M, var den Akker ME, van den Akker ES, de Boer MA. Non-invasive prenatal screen- ing for trisomy 21: What women want and are willing to pay. Patient Educ Couns 2013; 93: 641-5. 15. Bishop AJ, Marteau TM, Armstrong D, Chitty LS, Longworth L, Buxton MJ, et al. Women and health care professionals‘ preferences for Down‘s syndrome screen- ing tests: a conjoint analysis study. BJOG 2004; 111: 775-9. 16. de Jong A, Maya IM, van Lith JMM. Prenatal screening: current practice, new developments, ethical challenges. Bioethics 2015; 29: 1-8. 17. Kristjánsdóttir H, Steingrímsdóttir Þ, Ólafsdóttir ÓÁ Björnsdóttir Á, Sigurðsson JÁ. Barneign og heilsa. Ferilrannsókn meðal íslenskra kvenna frá því snemma á meðgöngu þar til tveimur árum eftir fæðingu barns. Ljósmæðrablaðið 2012; 2: 13-21. 18. Mulvey S, Zachariah R, McIlwaine K, Wallace EM. Do women prefer to have screening tests for Down syndrome that have the lowest screen-positive rate or the highest detection rate? Prenat Diagn 2003; 23: 828-32. 19. Kormáksdóttir G. Er munur á þjónustu fyrir verð- andi foreldra varðandi fósturskimanir eftir búsetu? Meistaraverkefni í ljósmóðurfræði. Háskóli Íslands 2013. 20. Stefansdottir V, Skirton H, Jonasson K, Hardardottir H, Jonsson, JJ. Effects of knowledge, education, and experience on acceptance of first trimester screening for chromosomal anomalies. Acta Obstet Gynecol 2010; 89: 931-8. 21. Ryan M, Farrar S. Using conjoint analysis to elicit prefer- ences for health care. BMJ 2000; 320: 1530-3. ENGLISH SUMMARY Introduction: Prenatal screening in early pregnancy is offered to all women in Iceland. In the case of an increased risk, invasive diagnostic test with 1% risk of fetal loss is offered. Recent developments include an exploration of a cell free fetal DNA in maternal plasma. The aim of this study was to explore factors that are of importance to pregnant women and professionals in fetal diagnosis. Material and methods: A questionnaire incorporating a discrete choice experimental design was used. The population included all pregnant women attending antenatal care in the capital area from June to Novem- ber 2014 and all health professionals provide prenatal care in Iceland. We included all health professionals who provide prenatal care and a convenience sample of 300 pregnant women attending primary health clinics, who were more than 20 weeks pregnant, had declined screening or had low risk result. Results: Overall pregnant women and professionals prefer a test which is accurate and safe, performed early in pregnancy and provides thorough information. In comparison with the health professionals, who responded to the questionnaire (20,8%, 61/293), the pregnant women placed greater emphasis on test safety and comprehensive information but less on accuracy and early testing. Conclusion: Similar results can be found in other studies but it is of importance to gain knowledge of pregnant women´s and professionals views before a new method in screening contexts is implimented in Iceland. Good counseling is of importance to ensure that women under- stand all aspects of the technique which increases informed choices. Key words: non-invasive prenatal testing (NIPT); Down syndrome; discrete choice experiment; women’s preferences; health professionals’ attitudes. Women´s preferences for prenatal tests A discrete choice experiment to contrast noninvasive prenatal testing with current invasive tests Sigrún Ingvarsdóttir, Vigdís Stefánsdóttir, Helga Gottfreðsdóttir Key words: non-invasive prenatal testing (NIPT), Down syndrome; discrete choice experiment; womens’ preferences; health professionals’ attitudes. Correspondence: Sigrún Ingvarsdóttir, sigruing@landspitali.is R A N N S Ó K N
Blaðsíða 1
Blaðsíða 2
Blaðsíða 3
Blaðsíða 4
Blaðsíða 5
Blaðsíða 6
Blaðsíða 7
Blaðsíða 8
Blaðsíða 9
Blaðsíða 10
Blaðsíða 11
Blaðsíða 12
Blaðsíða 13
Blaðsíða 14
Blaðsíða 15
Blaðsíða 16
Blaðsíða 17
Blaðsíða 18
Blaðsíða 19
Blaðsíða 20
Blaðsíða 21
Blaðsíða 22
Blaðsíða 23
Blaðsíða 24
Blaðsíða 25
Blaðsíða 26
Blaðsíða 27
Blaðsíða 28
Blaðsíða 29
Blaðsíða 30
Blaðsíða 31
Blaðsíða 32
Blaðsíða 33
Blaðsíða 34
Blaðsíða 35
Blaðsíða 36
Blaðsíða 37
Blaðsíða 38
Blaðsíða 39
Blaðsíða 40
Blaðsíða 41
Blaðsíða 42
Blaðsíða 43
Blaðsíða 44
Blaðsíða 45
Blaðsíða 46
Blaðsíða 47
Blaðsíða 48
Blaðsíða 49
Blaðsíða 50
Blaðsíða 51
Blaðsíða 52
Blaðsíða 53
Blaðsíða 54
Blaðsíða 55
Blaðsíða 56

x

Læknablaðið

Beinir tenglar

Ef þú vilt tengja á þennan titil, vinsamlegast notaðu þessa tengla:

Tengja á þennan titil: Læknablaðið
https://timarit.is/publication/986

Tengja á þetta tölublað:

Tengja á þessa síðu:

Tengja á þessa grein:

Vinsamlegast ekki tengja beint á myndir eða PDF skjöl á Tímarit.is þar sem slíkar slóðir geta breyst án fyrirvara. Notið slóðirnar hér fyrir ofan til að tengja á vefinn.