Læknablaðið - 15.02.2002, Page 31

FRÆÐIGREINAR / ÁHRIF LÝSIS / ÍKOMUSTAÐUR SÝKINGAR
áhrifum lýsisins er miðlað um ónæmiskerfið, eins og
við gerum ráð fyrir, ætti íkomustaður sýkingarinnar
að skipta litlu máli. Rannsókn okkar nú þar sem
mýsnar voru sýktar í lungu renna frekari stoðum
undir þá kenningu að lýsisáhrifunum sé miðlað um
ónæmiskerfið og endurspegli ekki staðbundin við-
brögð í ákveðnum vefjum. Hafa verður í huga að
fyrsta ónæmissvarið er nokkuð mismunandi í lungum
eða í vöðva. Við innspýtingu í vöðva er farið fram hjá
yfirborðsvörnum líkamans en við sýkingu í lungu eru
fyrstu varnir líkamans virkar. Yfirborðsvarnir í lung-
um eru þó ekki afgerandi í viðbrögðum við stórum
sýkingaskammti af Gram neikvæðum bakteríum.
Niðurstöðurnar benda til að jákvæð áhrif fáist
fram, óháð íkomustað sýkinganna. Þessar niðurstöð-
ur renna stoðum undir þá kenningu að lýsi virki á
almennt ónæmissvar líkamans.
Þakkir
Sonja Vilhjálmsdóttir annaðist dýrahald á Keldum.
Örn Ólafsson annaðist tölfræðiútreikninga. Styrkir
til rannsóknarinnar fengust frá RANNÍS, Nýsköpun-
arsjóði námsmanna, Lýsi ehf, Aðstoðarmannasjóði
Háskóla íslands og Vísindasjóði Landspítala. Sýkla-
fræðideild Landspítala lagði til bakteríurnar.
Heimildir
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