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Læknablaðið - 15.06.2013, Blaðsíða 20

Læknablaðið - 15.06.2013, Blaðsíða 20
RANNSÓKN Heimildir 1. Anderson, T. D., L. A. Loevner, et al. (2000). „Prevalence of unsuspected acoustic neuroma found by magnetic resonance imaging." Otolaryngol Head Neck Surg 122(5): 643-6. 2. Spoelhof GD. When to suspect an acoustic neuroma. Am Fam Physician 1995; 52(6): 1768-74. 3. Bird PA, MacFarlane MR. Management of unilateral vesti- bular schwannoma/acoustic neuroma. The New Zealand medical joumal 2007; 120:1265. 4. Bronstein AM. Vision and vertigo: some visual aspects of vestibular disorders. J Neurol. 2004; 251: 381-7. 5. Moffat DA, Jones SE, Mahendran S, Humphriss R, Baguley DM. Referral pattems in vcstibular schwannomas,10 years on. Clin Otolaryngol Allied Sci. 2004; 29(5): 515-7. 6. Tos M, Thomsen J, Charabi S. Incidence of acoustic neuromas. Ear Nose Throat J. 1992; 71:391-3. 7. Tos M, Charabi S, Thomsen J. Incidence of vestibular schwannomas. Laryngoscope 1999; 109: 736-40. 8. Tos M, Stangerup SE, Cayé-Thomasen P, Tos T, Thomsen J. What is the real incidence of vestibular schwannoma? Archives of Otolaryngology-Head & Neck Surgery 2004; 130(2): 216-20. 9. Larjavaara S, Feychting M, Sankila R, Johansen C, Klaeboe L, Schiiz J, Auvinen A. Incidence trends of vestibular schwannomas in Denmark, Finland, Norway and Sweden in 1987-2007. Br J Cancer. 2011; 105(7): 1069-75. 10. Stangerup SE, Tos M, Caye-Thomasen P, Tos T, Klokker M, Thomsen J. Increasing annual incidence of vestibular schwannoma and age at diagnosis. J Laryngol Otol. 2004; 118(8): 622-7. 11. Chopra R, Kondziolka D, Niranjan A, Lunsford LD, Flickinger JC. Long-term follow-up of acoustic schwan- noma radiosurgery with marginal tumor doses of 12 to 13 Gy. Int J Radiat Oncol Biol Phys. 2007; 68(3): 845-51. 12. Jeyakumar A, Seth R, Brickman TM, Dutcher P. The prevalence and clinical course of patients with ,incidental' acoustic neuromas. Acta Otolaryngol. 2007; 127(10): 1051- 7. 13. Myrseth E, Pedersen PH, Moller P, Lund-Johansen M. Treatment of vestibular schwannomas. Why, when and how? Acta Neurochir (Wien) 2007; 149(7): 647-60. 14. Hain TC. Acoustic neuroma. Northwestem University Medical School Chicago 2008. Updated Feb 16, 2009. www.dizziness-and-balance.com/disorders/tumors/ acoustic_neuroma.htm - apríl 2009. 15. Hoffman RA. Neurotologic evaluation and management of acoustic neuroma. Bull N V Acad Med. 1979; 55(8): 751- 6. 16. Karpinos M, Teh BS, Zeck O, Carpenter LS, Phan C, Mai WY, et al. Treatment of acoustic neuroma: stereotactic radiosurgery vs. microsurgery. Int J Radiat Oncol Biol Phys.2002; 54(5): 1410-21. 17. Myrseth E, Moller P, Pedersen PH, Lund-Johansen M. Vestibular Schwannoma: Surgery or Gamma Knife Radiosurgery? A Prospective, Nonrandomized Study. Neurosurgery 2009; 64(4): 654-61. 18. Myrseth E, Moller P, Pedersen PH, Vassbotn FS, Wentzel- Larsen T, Lund-Johansen M. Vestibular schwannomas: Clinical results and quality of life after microsurgery or gamma knife radiosurgery. Neurosurgery 2005; 56(5): 927- 34. 19. House JW, Brackmann DE. Facial nerve grading system. Otolaryngol Head Neck Surg. Apr 1985; 93(2): 146-7. 20. Stangerup SE, Caye-Thomasen P, Tos M, Thomsen J. The natural history of vestibular schwannoma. Otol Neurotol. 2006; 27(4): 547-52. 21. Solares CA, Panizza B. Vestibular schwannoma: An understanding of growth should influence management decisions. Otology & Neurotology 2008; 29(6): 829-34. 22. Smouha EE, Yoo M, Mohr K, Davis RP. Conservative management of acoustic neuroma: a meta-analysis and proposed treatment algorithm. Laryngoscope. 2005; 115(3): 450-4. ENGLISH SUMMARY Acoustic Neuroma in lceland for 30 years (1979-2009) GudmundssonThH', Petersen H' 2 Introduction: Acoustic neuroma (AN) is a tumor of the 8th cranial nerve. The goal of this study was to find the incidence of AN in lceland from 1979 - 2009 as well as investigate other epidemiological factors. Material and Methods: The group of patients with the AN diagnosis was gathered retrospectively through medical records. We looked at several epidemiological factors including age and symptoms at diag- nosis, and the treatment chosen foreach individual. Results: The incidence rate of AN in lceland is 1.24/100,000. About 10% of diagnosed tumors were found incidentally. Most of those were found in the last 10 years of the investigation and in that period fewer large and giant tumors at diagnosis. Present complaints of patients at diagnosis were hearing loss (69%), dysequilibrium/dizziness (47%) and tinnitus (43%). Treatments were surgery (n=47), observation (n=30) and gamma knife radiosurgery (n=16). We had information concerning postoperative hearing loss and facial paralysis in 39 patients who underwent surgery. Loss of hearing postoperatively occurred in 69% (n=27) and 44% (n=17) had facial paralysis. For an average of 3.5 years, 17% of tumors followed by imaging grew. Conclusion: The incidence of AN is similar to that in Europe and is increasing. More tumors are found incidentally. Small tumors can be followed by regular imaging, at least for the short term. Larger tumors are treated by surgery or gamma knife radiosurgery. A high percentage of patients receiving surgery lost their hearing postoperatively. Key words: Acoustic neuroma, acoustic tumor, vestibular schwannoma, acoustic schwannoma Correspondence: Þorsteinn H. Guðmundsson, thhg86@gmail.com 'Department of Life Sciences, University of lceland, 2Department of Otorhinolaryngology Head and Neck Surgery, Landspítali, Reykjavik, lceland 292 LÆKNAblaðið 2013 /99

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