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Læknablaðið - 15.12.2007, Qupperneq 20

Læknablaðið - 15.12.2007, Qupperneq 20
FRÆÐIGREINAR METÝLFENÍDAT kostnað stuttverkandi lyfjaforms. Samanborið við Evrópulönd er notkun metýlfenídats á íslandi mikil. Aldursdreifing og kynhlutfall lyfjanotkunar er svipað og víðast annars staðar og kemur einnig heim og saman við dreifingu ADHD hjá börnum. Miðað við tíðnitölur ADHD er ekki hægt að álykta að um ofnotkun lyfjanna sé að ræða hér á landi. Hins vegar er nauðsynlegt að vandlega sé staðið að greiningu ADHD hjá börnum og að önnur meðferðar- og stuðningsúrræði séu reynd fyrir og samhliða lyfjagjöf. Mikilvægt er að stuðla að skyn- samlegri lyfjanotkun og að þeir hljóti viðeigandi meðferð sem á þurfa að halda. Höfundar leggja til frekari að gerður verði frek- ari samanburður á geðlyfjanotkun og meðferð- arúrræðum barna milli landa í framtíðinni. Einnig er þarft að kanna algengi og dreifingu lyfjanotk- unar við ADHD hjá fullorðnum á íslandi. Loks hlýtur það að teljast verðugt verkefni að kostn- aðargreina meðferðarúrræði ADHD, til dæmis hvort aukin notkun dýrari lyfjaforma sé þjóðhags- lega hagkvæm. Þakkir Þakkir fá Hrefna Þorbjarnardóttir, ritari og Kristinn Jónsson, kerfisfræðingur. Heimildir 1. Costello EJ, Mustillo S, Erkanli A, Keeler G, Angold A. Prevalence and development of psychiatric disorders in childhood and adolescence. Arch Gen Psychiatry 2003; 60: 837-44. 2. Cuffe SP, Moore CG, McKeown RE. Prevalence and correlates of ADHD symptoms in the national health interview survey. J Atten Disord 2005; 9: 392-401. 3. Woodruff TJ, Axelrad DA, Kyle AD, Nweke O, Miller GG, Hurley BJ.Pediatrics. Trends in environmentally related childhood illnesses 2004; 113:1133-40. 4. Faraone SV, Sergeant J, Gillberg C, Biederman J. The worldwide prevalence of ADHD: is it an American condition? World Psychiatry 2003; 2:104-13. 5. Barkley RA. Primary Symtoms, Diagnostic Criteria, Prevalence, and Gender Differences. In: Barkley RA, ed. Attention Deficit/Hyperactivity disorder. A handbook for diagnosis and treatment. Third edition. New York: Guilford 2005: 76-121. 6. Bradley C. The behavior of children receiving benzedrine. Am J Psychiatry 1937; 94: 577-85. 7. Barkley RA. History. In: Barkley RA, ed. Attention Deficit/ Hyperactivity disorder. A handbook for diagnosis and treatment. Third edition. New York: Guilford 2005:3-52. 8. Connor DF. Stimulants. In: Barkley RA, ed. Attention Deficit/ Hyperactivity disorder. A handbook for diagnosis and treatment. Third edition. New York: Guilford 2005: 608- 47 . 9. Scheffler RM, Hinshaw SP, Modrek S, Levine P. The global market for ADHD medications. Health Aff (Millwood) 2007; 26:450-57. 10. Olfson M, Marcus SC, Weissman MM, Jensen P. National Trends in the Use of Psychotropic Medications by Children. J Am Acad Child Adolesc Psychiatry 2002; 41:514 -21. 11. Zuvekas SH, Vitiello B, Norquist GS. Recent Trends in Stimulant Medication Use Among U.S. Children. Am J Psychiatry 2006; 163: 579-85. 12. National Institute for Health and Clinical Excellence, National Health Service. NICE implementation uptake report: attention deficit hyperactivity disorder, 16.04.2007: www.nice.org.uk 13. The Norwegian Institute of Public Health. Over 11 000 bam og unge behandles med ADHD-medisiner. Reseptbasert legemiddelregister, Grossistbasert legemiddelstatistikk. 13.02.2006, 01.03.2007: www.fhi.no 14. The Danish Medicines Agency. Lægemiddelstatistikregisteret: www.medstat.dk 15. Lyfjadeild TR - lyfjaskírteini vinnureglur. Metýlfenídat. 1. júm' 2007 www.tr.is 16. Castle L, Aubert RE, Verbrugge RR, Khalid M, Epstein RS. Trends in medication treatment for ADHD. J Atten Disord 2007; 10: 335-42. 17. Banaschewski T, Coghill D, Santosh P, Zuddas A, Asherson P, Buitelaar J, et. al.Long-acting medications for the hyperkynetic disorders: A systematic review and European treatment guidelines. Eur Child Adolesc Psychiatry 2006; 15: 476-95. 18. Baldursson G, Magnusson P, Guðmundsson OO. Greiningar og meðferðarúrræði 102 bama og unglinga sem komu til bama- og unglingageðdeildar Landsptítalans vegna ofvirknieinkenna frá 1. júní 1998 til 31. maí 1999. Læknablaðið 2000; 86: 337-42. 19. Faraone SV, Biederman J, Weber W, Russell RL. Psychiatric, neuropsychological, and psychosocial features of DSM-IV subtypes of attention-deficit/hyperactivity disorder: results from a clinically referred sample. J Am Acad Child Adolesc Psychiatry 1998; 37:185-93. 20. Jónsdóttir S. ADHD and its relationship to comorbidity and gender. Doktorsritgerð varin við læknadeild Rijksuniversiteit Groningen, Hollandi 27. september 2006. 21. Biederman J, Mick E, Faraone SV, Braaten E, Doyle A, Spencer T, et. al. Influence Of Gender On Attention Deficit Hyperactivity Disorder In Children Referred To A Psychiatric Clinic. Am J Psychiatry 2002; 159: 36-42. 22. American Academy of Pediatrics. Clinical practice guideline: diagnosis and evaluation of the child with attention-deficit/ hyperactivity disorder. Pediatrics 2000; 105:1158-70. 23. Cox ER, Motheral BR, Henderson RR, Mager D. Geographic variation in the prevalence of stimulant medication use among children 5 to 14 years old: results from a commercially insured US sample. Pediatrics 2003; 111:237-43. 24. Milton A, Eberhard D. Child and adolescent psychiatry in Iceland: Report from a brief study tour. September 2006. 25. MTA Cooperative group. A 14-month randomized clinical trial of treatment strategies for attention-deficit/hyperactivity disorder. Multimodal treatment study of children with ADHD. Arch Gen Psychiatry 1999; 56:1097-9. 26. Conners CK, Epstein JN, March JS, Angold, A, Wells K C, Klaric J, et al. Multimodal treatment of ADHD in the MTA: An altemative outcome analysis. J Am Acad Child Adolesc Psychiatry 2001; 40:159-67. 27. MTA Cooperative Group. National Institute of Mental Health Multimodal Treatment Study of ADHD follow up: 24-month outcomes of treatment strategies for attention-deficit/ hyperactivity disorder. Pediatrics 2004; 113: 754-61. 28. Barkley RA, McMurray MB, Edelbrock CS, Robbins K. Side effects of methylphenidate in children with attention deficit hyperactivity disorder: a systemic, placebo-controlled evaluation. Pediatrics 1990; 86:184-92. 29. Greenhill LL, Halperin JM, Abikoff H. Stimulant medications. Am Acad Child Adolesc Psychiatry 1999; 38:503-12. 30. Santosh PJ, Taylor E. Stimulant drugs. Eur Child Adolesc Psychiatry 2000; 9:127-43. 31. Volkow ND, Ding YS, Fowler JS, Wang GJ, Logan J, Gatley JS. Is methylphenidate like cocanine? Studies on their pharmacokinetics and distribution in the human brain. Arch Gen Psychiatry 1995; 52: 456-63. 32. Wilens TE, Faraone SV, Biederman J, Gunawardene, S. Does stimulant therapy of attention deficit/hyperactivity disorder beget later substance abuse? A meta-analytic review of the literature. Pediatrics 2003; 111:179-85. 832 LÆKNAblaðið 2007/93
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