Læknablaðið - 15.11.2008, Blaðsíða 33

FRÆÐIGREINAR
Y F I R L I T
5. Tumpey TM, Basler CF, Aguilar PV, et al. Characterization
of the reconstructed 1918 Spanish influenza pandemic virus.
Science 2005; 310: 77-80.
6. Oner A, Bay A, Arslan S, et al. Avian influenza A (H5N1)
infection in eastem Turkey in 2006. N Engl J Med 2006; 355:
2179-2.
7. Kandun I, Wibisono H, Sedyaningsih E, et al. Three
Indonesian clusters of H5N1 vims infection in 2005. N Engl J
Med 2006; 355: 2186-94.
8. Mills CE, Robins JM, Lipsitch M. Transmissibility of 1918
pandemic influenza. Nature 2004; 432: 904-6.
9. Beigel JH, Farrar J, Han AM, et al. Avian influenza A (H5N1)
infection in humans. N Engl J Med 2005; 353:1374-85.
10. Bmndage JF, Shanks GD. Deaths from bacterial pneumonia
during 1918-19 influenza pandemic. Emerg Infect Dis. 2008;
14:1193-9.
11. Gottfredsson M (2008). Lessons from the 1918 Spanish flu
epidemic in Iceland. í (Georgiev V, Western KA, McGowan
JJ, ritstjórar): National Institute of Allergy and Infectious
Diseases, NIH. Vol. 1. Frontiers in Researdí. Humana Press,
New Jersey, 2008:115-22.
12. Gottfredsson M, Halldórsson BV, Jónsson S, et al. Lessons
from the past: familial aggregation analysis of fatal pandemic
influenza (Spanish flu) in Iceland in 1918. Proc Natl Acad Sci
USA2008; 105:1303-8.
13. Ásgeirsson V. „Engill dauðans". Spænska veikin á íslandi
1918-1919. Saga 2008; 46: 76-114.
14. Ólafsson BÞ. Neyðarhjálp í Reykjavík í spænsku veikinni
1918. Saga 2008; 46: 209-15.
15. Thoroddsen Þ. Inflúenzan fyrrum og nú. Læknablaðið 1919;
5:13-23 og 74-9.
16. Landlæknir. Heilbrigðisskýrslur 1918. 51-6.
17. [Anonymous]. Spanska veikin. Morgunblaðið 21 okt. 1918,
5(344):3.
18. [Anonymous]. Spanska veikin í Frakklandi. Morgunblaðið
21. okt. 1918, 5(344):1.
19. [Anonymous]. Spánska veikin. Morgunblaðið 25. okt. 1918,
5(348):1.
20. [Anonymous]. Spanska veikin. Skal flotið „sofandi að
feigðarósi"? Morgunblaðið 27. okt. 1918,5(350):1.
21. [Anonymous]. Dagbók. Morgunblaðið 27. okt. 1918,5(350):3.
22. Bjömson G. „Spanska pestin". Morgunblaðið 29. okt. 1918,
5(352):1-2.
23. Bjömsson G. „Spanska pestin" (Influenzan) II. Morgunblaðið
30. okt. 1918,5(353):2.
24. Bjömsson G. „Spanska pestin" (Influenzan) III. Morgunblaðið
31. okt. 1918,5(353):2.
25. Bjömsson G. „Spanska pestin" (Influenzan) IV. Morgunblaðið
2. nóv. 1918, 6(2):1.
26. Bjömsson G. „Spanska pestin" (Influenzan) V. Morgunblaðið
3. nóv. 1918, 6(3):1.
27. [Anonymous]. Dagbók. Morgunblaðið 3. nóv. 1918, 6(3): 3.
28. [Anonymousj. Dagbók. Morgunblaðið 5. nóv. 1918, 6(3): 3.
29. [Anonymousj. Lyfjabúðin og Inflúenzan. Morgunblaðið 6.
nóv, 1918,6(3): 2.
30. [Anonymous]. Sóttin mikla. Morgunblaðið 17. nóv. 1918,6(7):
Í-3.
31. Haraldsson G. Læknar á íslandi. III bindi, 4. útg., 3. bindi.
Þjóðsaga ehf. Reykjavík, 2000:1660-1.
32. J[ónsson] S. Hugleiðingar um influensuna. Læknablaðið
1918; 4:180-2.
33. Kolka PVG. Spænska veikin. í: Úr myndabók læknis. Setberg,
Reykjavík, 1964, bls 31-50.
34. H[annesson] G. Fréttir. Læknablaðið 1918; 4:190.
35. Þórðarson Þ. Dagbók, mars 1919. Auðkennd með ke 34 (13).
Óbirt handrit, geymt í handritadeild Þjóðarbókhlöðu.
36. Gunnarsson G. Sælir em einfaldir. Almenna Bókafélagið,
Reykjavík 1976.
37. Markel H, Stem AM, Navarro JA, Michalsen JR, Monto AS,
DiGiovanni C. Nonpharmaceutical influenza mitigation
strategies, US communities, 1918-1920 pandemic. Emerg
Infect Dis 2006; 12:1961-4.
38. Simonsen L, Clarke MJ, Schonberger LB, Arden NH, Cox NJ,
Fukuda K. Pandemic versus epidemic influenza mortality: a
pattem of changing age distribution. J Infect Dis 1998; 178:
53-60.
39. Kobasa D, Jones SM, Shinya K, , et al. Aberrant innate
immune response in lethal infection of macaques with the
1918 influenza vims. Nature 2007; 445: 319-23.
40. de Jong MD, Simmons CP, Thanah TT, et al. Fatal outcome of
human influenza A (H5N1) is associated with high viral load
and hypercytokinemia. Nat Med 2006; 12:1203-7.
41. Kash JC, Tumpey TM, Proll SC, et al. Genomic analysis of
increased host immune and cell death responses induced by
1918 influenza vims. Nature 2006; 443 :578-81.
42. Bland PB. Influenza in its relation to pregnancy and labour.
Am J Obstet Dis Women Child 1919; 79:184-97.
43. Harris JW. Influenza occurring in pregnant women: a
statistical study of thirteen hundred and fifty cases. JAMA
1919; 72: 978-80.
44. Neuzil KM, Reed GW, Mitchel EF, Simonsen L, Griffin
MR. Impact of influenza on acute cardiopulmonary
hospitalizations in pregnant women. Am J Epidemiol 1998;
148:1094-102.
45. Jamieson DJ, Theiler RN, Rasmussen SA. Emerging infections
and pregnancy. Emerg Infect Dis 2006; 12:1638-43.
46. Dowell SF, Bresee JS. Pandemic lessons from Iceland. Proc
Natl Acad Sci USA 2008; 105:1109-10.
47. Albright FS, Orlando P, Pavia AT, Jackson GG, Albright
LAC. Evidence for a heritable predisposition to death due to
influenza. J. Infect Dis 2008; 197:18-24.
48. ísberg JÓ. Líf og lækningar. íslensk heilbrigðissaga. Hið
íslenska bókmenntafélag. Reykjavík 2005:187-92.
Gottfreðsson M
The Spanish flu in lceland 1918. Lessons in medicine and history
Pandemic influenza has emerged 1-3 times each century.
The pandemic in 1918, or the „Spanish flu“ was caused by
a novel influenza strain which caused the death of 21-50
million people worid wide. Descriptions of the epidemic
in lceland give a detaiied account on how and when the
virus was introduced to the population of Reykjavik, the
capital of lceland, by the crew of two ships, „Botnía“-
and „Willemoes“ on October 19th 1918. The spread of
the illness was extremely rapid and peaked 3 weeks
later. It caused significant morbidity and mortality among
inhabitants of the southern and western part of lceland.
Within 6 weeks, close to 500 individuals had died, thereof
more than 50% in Reykjavik. The attack rate in Reykjavik
Key words: Spanish fíu, infiuenza, epidemiology, mortality, infection control
Correspondence: Magnús Gottfreðsson magnusgo@landspitali.is
was at least 63% and the case fatality proportion was
close to 2.6%. The age-specific mortality was highest
among young children, people 20-40 years of age and the
elderly. In addition, pregnant women had extremely poor
prognosis (37% case fatality). Attempts to halt the spread
of the epidemic to the northern and eastern parts of the
island were successful. By indentifying the individuals
who died from the Spanish flu using historical data, it has
recently been shown that genetic factors probably did
not play a major role in the pathogenesis of fatal cases.
These historical data can be used to assist in planning
for new pandemics of influenza, which are believed to be
inevitable.
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Barst: 3. september 2008, - samþykkt til birtingar: 21. október 2008.
LÆKNAblaðið 2008/94 745