Læknablaðið - 15.02.2011, Síða 25

FRÆÐIGREINAR
Y F I R L I T
Heimildir
1. Jónasson JG, Tryggvadóttir L. Krabbamein á íslandi -
Upplýsingar úr Krabbameinsskrá fyrir tímabilið 1957-2007.
[ritstjórar]. Krabbameinsfélagið; Reykjavík 30. apríl 2008.
2. Engholm G, Ferlay J, Christensen N, et al. NORDCAN:
Cancer Incidence, Mortality, Prevalence and Prediction in
the Nordic Countries, Version 3.6. Association of the Nordic
Cancer Registries. Danish Cancer Society 2010 (www.ancr.
nu).
3.. Lundgren CI, Hall P, Ekbom A, Frisell J, Zedenius J, Dickman
PW. Incidence and survival of Swedish patients with
differentiated thyroid acancer. Int J Cancer 2003; 106: 569-73.
4. Schneider AB, Same DH. Long-term risks for thyroid cancer
and other neoplasms after exposure to radiation. Nat Clin
Pract Endocrinol Metab 2005; 1: 82-91.
5. Colonna M, Grande E, Jonasson JG, Eurocare Working G.
Variation in relative survival of thyroid cancers in Europe:
results from the analysis on 21 countries over the period
1983-1994 (EUROCARE-3 study). Eur J Cancer 2006; 42:
2598-608.
6. Jonasson JG, Hrafnkelsson J. Nuclear DNA analysis and
prognosis in carcinoma of the thyroid gland. A nationwide
study in Iceland on carcinomas diagnosed 1955-1990.
Virchows Arch 1994; 425: 349-55.
7. Hrafnkelsson J, Jonasson JG, Sigurdsson G, Sigvaldason
H, Tulinius H. Thyroid cancer in Iceland 1955-1984. Acta
Endocrinol (Copenh) 1988; 118: 566-72.
8. Jonasson JG, Hrafnkelsson J, Bjomsson J. Tumours in Iceland.
11. Malignant tumours of the thyroid gland. A histological
classification and epidemiological considerations. APMIS
1989; 97: 625-30.
9. Delellis RA, Lloyd RV, Heitz PU. World Health Organization
Classification of tumours. In: C Eng, editor. Pathology and
Genetics of Tumors of Endocrine Organs. IARC Press, Lyon
2004.
10. Thyroid. In: Greene FL, editor. AJCC cancer staging
handbook from the AJCC cancer staging manual / American
Joint Committee on Cancer. 6th. Springer, New York 2002:
77-9.
11. Cancer incidence in five continents. Volume IV. IARC Sci
Publ 1982:1-807.
12. Davies L, Welch HG. Increasing incidence of thyroid cancer
in the United States, 1973-2002. JAMA2006; 295: 2164-7.
13. Colonna M, Bossard N, Guizard AV, Remontet L, Grosclaude
P. Descriptive epidemiology of thyroid cancer in France:
incidence, mortality and survival. Ann Endocrinol (Paris)
2010; 71:95-101.
14. Enewold L, Zhu K, Ron E, et al. Rising thyroid cancer
incidence in the United States by demographic and tumor
characteristics, 1980-2005. Cancer Epidemiol Biomarkers
Prev 2009; 18: 784-91.
15. Liu S, Semenciw R, Ugnat AM, Mao Y. Increasing thyroid
cancer incidence in Canada, 1970-1996: time trends and age-
period-cohort effects. Br J Cancer 2001; 85:1335-9.
16. Moo-Young TA, Traugott AL, Moley JF. Sporadic and familial
medullary thyroid carcinoma: state of the art. Surg Clin
North Am 2009; 89:1193-204.
17. Sassolas G, Hafdi-Nejjari Z, Remontet L, et al. Thyroid
cancer: Is the incidence rise abating? Eur J Endocrinol 2009;
160: 71-9.
18. Williams ED, Doniach I, Bjamason O, Michie W. Thyroid
cancer in iodide rich area: a histopathological study. Cancer
1977; 39: 215-22.
19. Sigurðsson G, Franzson L. Joðútskilnaður í þvagi íslenskra
karla og kvenna. Læknablaðið 1988; 74:179-81.
20. Mazzaferri EL, Jhiang SM. Long-term impact of initial
surgical and medical therapy on papillary and follicular
thyroid cancer. Am J Med 1994; 97: 418-28.
Thyroid cancer in lceland in the period
epidemiological study
Introduction: Thyroid cancer has been unusually common
in lceland. Histological classification and TNM-staging
has altered somewhat in the last decades. The aim of
this study was to investigate the epidemiology of thyroid
cancer in lceland over half a century and identify factors
affecting survival.
Material and methods: Information on all thyroid cancers
diagnosed in lceland from 1955 to 2004 was obtained
from the lcelandic Cancer Registry. Tumours diagnosed
post-mortem were excluded. The date of diagnosis, sex
and age at diagnosis was registered. All histopathology
material was re-evaluated to reclassify tumours and TNM-
stage was determined. The effect of registered parameters
on prognosis was determined both in uni- and multivariate
analysis.
Results: Out of 805 thyroid cancer cases in the study 588
were in women. The mean age was 51 years in women
1955-2004. A clinico-pathological and
and 58 years in men. The oscillation of incidence was
marked in the study period although it did not increase
in the last decades of the study. The overall proportion of
papillary carcinoma was around 80% and the proportion
of T0-T2 tumours was 66%. Neither number has changed
significantly in the last 40 years of the study. The overall
disease specific 5 year survival was 88% and increased
significantly in the study period. In a multivariate analysis
patient’s age, year of diagnosis, tumour type and TNM-
stage were independent significant prognostic variables.
Conclusion: Thyroid cancer incidence in lceland is no
longer different to that in many neighbouring countries.
Sex was not an independent prognostic parameter. The
year of diagnosis was an independent prognostic factor
which might indicate a more efficient treatment in later
years.
Jonasson JG, Hrafnkelsson J, Olafsdottir E.
Thyroid cancer in lceland in the period 1955-2004. A clinico-pathological and epidemiological study. - lcel Med J 2011; 97:83-9.
Key words; thyroid cancer, histological classification, TNM-staging, incidence, epidemiology.
Correspondence: Jón Gunnlaugur Jónasson, jongj@landspitali.is
>
œ
<
D
03
X
03
_l
O
z
LU
Barst: 2. júní 2010, - samþykkt til birtingar: 3. desember 2010
Hagsmunatengsl: Engin
LÆKNAblaðið 2011/97 89