Læknablaðið - 15.02.2011, Blaðsíða 25

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Thyroid cancer in lceland in the period
epidemiological study
Introduction: Thyroid cancer has been unusually common
in lceland. Histological classification and TNM-staging
has altered somewhat in the last decades. The aim of
this study was to investigate the epidemiology of thyroid
cancer in lceland over half a century and identify factors
affecting survival.
Material and methods: Information on all thyroid cancers
diagnosed in lceland from 1955 to 2004 was obtained
from the lcelandic Cancer Registry. Tumours diagnosed
post-mortem were excluded. The date of diagnosis, sex
and age at diagnosis was registered. All histopathology
material was re-evaluated to reclassify tumours and TNM-
stage was determined. The effect of registered parameters
on prognosis was determined both in uni- and multivariate
analysis.
Results: Out of 805 thyroid cancer cases in the study 588
were in women. The mean age was 51 years in women
1955-2004. A clinico-pathological and
and 58 years in men. The oscillation of incidence was
marked in the study period although it did not increase
in the last decades of the study. The overall proportion of
papillary carcinoma was around 80% and the proportion
of T0-T2 tumours was 66%. Neither number has changed
significantly in the last 40 years of the study. The overall
disease specific 5 year survival was 88% and increased
significantly in the study period. In a multivariate analysis
patient’s age, year of diagnosis, tumour type and TNM-
stage were independent significant prognostic variables.
Conclusion: Thyroid cancer incidence in lceland is no
longer different to that in many neighbouring countries.
Sex was not an independent prognostic parameter. The
year of diagnosis was an independent prognostic factor
which might indicate a more efficient treatment in later
years.
Jonasson JG, Hrafnkelsson J, Olafsdottir E.
Thyroid cancer in lceland in the period 1955-2004. A clinico-pathological and epidemiological study. - lcel Med J 2011; 97:83-9.
Key words; thyroid cancer, histological classification, TNM-staging, incidence, epidemiology.
Correspondence: Jón Gunnlaugur Jónasson, jongj@landspitali.is
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Barst: 2. júní 2010, - samþykkt til birtingar: 3. desember 2010
Hagsmunatengsl: Engin
LÆKNAblaðið 2011/97 89