Læknablaðið - 15.07.2010, Page 16

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Allergen immunotherapy in lceland 1977-2006
Introduction: The prevelance of allery and asthma
has increased rapidly over the last 3 decades and is
now estimated that 25-30% of population in Western
industrialized countries show symptoms of allergy or
asthma. The aim of this study was to reveal the success
of allergen immunotherapy (AIT) in Landspitali from 1977-
2006.
Material and methods: During the study period a total
number of 289 individuals underwent immunotherapy in
outpatient clinic of allergy and asthma in Landspítali. A
total number of 169 individuals were contacted, of whom
128 (76%) accepted to participate in the study. The
evaluation was based on medical records, standardized
questionnaire and skin-prick tests.
Results: Patients were evaluated on the average of 20
years after finishing treatment. 118 (92%) patients were
desensitized to grass pollen, to birch pollen (30%), cat
dander (30%) and dust mite (28%). At the time of the
study 67% reported to be asymptomatic or with greatly
improved allergy symptoms. Males had better response
to AIT than women (p=0.04). Participants with positive
family history of allergy and/or asthma in first degree
relatives also reported better response to AIT (p=0.02).
Furthermore, AIT to grass pollen and dust mite seemed
to be more effective than AIT to cat dander and birch
(p=0.04). AIT was also shown to reduce asthma.
Conclusion: AIT for 3-5 years provides significant
beneficial effect of allergy and asthma symptoms in
patients who undergo such therapy. Finally, it's findings
support the notion that AIT may reduce the risk of new
allergic manifestations.
Rikardsson SG, Löve YB, Jorgensen GH, Gislason D, Ludviksson BR.
Allergen immunotherapy in lceland 1977-2006. Icel Med J 2010; 96:463-8.
Keywords: allergy, allergen immunotherapy, asthma, long term effect.
Correspondance: Björn Rúnar Lúðvíksson, bjornlud<Slandspitali.is
468 LÆKNAblaðií 2010/96
Barst: 9. desember 2009, - samþykkt til birtingar: 15. júní 2010
Hagsmunatengsl: Engin