Læknablaðið - 15.02.1996, Síða 36

142
LÆKNABLAÐIÐ 1996; 82
Table I. Correlation (Rs) between prognostic variables.
Prognostic variable DNA-ploidy* ■'í co co II c S-phase (n=329)
Rs p-value Rs p-value
Age (n=334) -0.10 0.03 -0.20 0.002
Tumor size (n=334) -0.01 0.82 0.10 0.04
Axillary lymph nodes (n=278) 0.05 0.38 0.09 0.16
TNM stage** (n=334) 0.09 0.06 0.10 0.01
Estrogen receptor (n=173) -0.08 0.93 -0.20 0.004
Progesterone receptor (n=152) -0.07 0.42 -0.20 0.01
S-phase (n=329) 0.70 <0.001 — —
* Diploid=1 and non-diploid=2
** Stage; 1=1, lla=2, llb=3, lll=4, IV=5
Table II. Breast cancer and disease-free survival in relation to prognostic variables at 7.5 years of follow-up.
Prognostic variable Number of patients (%) Breast cancer- survival (%) Disease-free survival (%)
Age, years p=0.01 p=0.02
<40 25 (7) 37 52
40-<49 64 (19) 70 79
50-<59 66 (19) 51 66
60-<69 80 (23) 62 72
70-<79 54 (16) 62 66
&80 55 (16) 70 72
Age categories p=0.20 p=0.39
<50 years 89 (26) 71 61
s=50 years 255 (74) 67 58
Tumor size p=0.0002 p=0.004
«20 mm 155 (45) 77 65
>20 mm 187 (55) 61 55
Axillary lymph node status p<0.0001 p<0.0001
Node-negative 150 (54) 85 77
Node-positive 128 (46) 55 40
TNM stage p<0.0001 p<0.0001
I (T1N0) 99 (29) 89 82
lia (T2-3N0) 91 (27) 84 77
lib (T1-2N1) 101 (30) 63 50
III (T3N1 ,T4 og N2-3) 18 (5) 21 21
IV (M1) 31 (9) 9 —
Estrogen receptor content p=0.04 =0.07
<10 fmol/mg protein 53 (31) 58 45
2=10 fmol/mg protein 117 (69) 71 57
Progesterone receptor content p=0.02 p=0.03
<10 fmol/mg protein 73 (49) 60 47
2=10 fmol/mg protein 76 (51) 75 67
DNA ploidy status p=0.008 p=0.004
Diploid 110 (33) 77 69
Non-diploid 219 (67) 64 54
S-phase fraction p<0.0001 p<0.0001
<7.0% 160 (49) 82 74
2=7.0% 164 (51) 55 44