Læknablaðið - 15.11.2004, Qupperneq 30

FRÆÐIGREINAR / SEGULÖRVUN HEILA
annarra taugasjúkdóma og geðraskana, þar má eink-
um nefna Parkinson sjúkdóm og geðklofa (33, 34).
Lokaorð
Segulörvun er nýleg rannsóknaraðferð sem er notuð
til að fá betri lífeðlisfræðilega innsýn í starfsemi heil-
ans og auka lífeðlismeinafræðilegan skilning á heila-
sjúkdómum. Margt bendir til þess að einnig verði far-
ið að nota þessa aðferð til að meðhöndla einhverja
tauga- og geðsjúkdóma í framtíðinni. A taugarann-
sóknastofu Landspítala er segulörvun notuð til að
meta leiðslu taugaboða í miðtaugakerfi. Einnig hafa
farið þar fram rannsóknir á notagildi segulörvunar í
meðferð jafnvægistruflana og þunglyndis (35).
Heimildir
1. Stefánsson SB, Bjömsson ÓG, Jóhannesson G. Stutt ágrip af
sögu klínískrar taugalífeðlisfræði. Bók Davíðs, Reykjavík Há-
skólaútgáfa 1996; 925-42.
2. Barker A, Freeston I, Jalinous R, Merton P, Morton H. Magnetic
stimulation of the human brain. J Physiol 1985; 369: 3.
3. Merton PA, Morton HB. Stimulation of cerebral cortex in intact
human subjects. Nature 1980; 285:227.
4. Wassermann EM. Risk and safety of repetitive transcranial
magnetic stimulation: report and suggested guidelines from the
International Workshop on the Safety of Repetitive Transcranial
Magnetic Stimulation. Electroencephalogr Clin Neurophysiol
1998; 108:1-16.
5. Dawson GD. A summation technique for detecting small signals
in a large irregular background. J Physiol 1951; 115:2-3.
6. Hess CW, Mills KR, Murray NMF, Schriefer TN. Magnetic brain
stimulation: central motor conduction studies in multiple scle-
rosis. Ann Neurol 1987; 22:744.
7. Berardelli A, Inghilleri M, Cruccu G, Mercuri B, Manfredi M.
Electrical and magnetic transcranial stimulation in patients with
corticospinal damage due to stroke or motor neurone disease.
Electroencephalogr Clin Neurophysiol 1991; 81: 389-96.
8. Maertens de Noordhout A, Myressiotis S, Delvaux V, Born JD,
Delwaide PJ. Motor and somatosensory evoked potentials in
cervical spondylotic myelopathy. Electroencephalogr Clin Neur-
ophysiol 1998; 108: 24-31.
9. Boroojerdi B, Battaglia F, Muellbacher W, Cohen LG. Mechan-
isms influencing stimulus-response properties of the human cort-
icospinal system. Clin Neurophysiol 2001; 112:931-7.
10. Boroojerdi B. Pharmacologic influences on TMS effects. J Clin
Neurophysiol 2002; 19:255-71.
11. Priori A, Berardelli A, Inghilleri M, Accomero N, Manfredi M.
Motor cortical inhibition and the dopaminergic system. Phar-
macological changes in the silent period after transcranial brain
stimulation in normal subjects, patients with Parkinson’s disease
and drug-induced parkinsonism. Brain 1994; 117: 317-23.
12. Steele JD, Glabus MF, Shajahan PM, Ebmeier KP. Increased
cortical inhibition in depression: a prologned silent period with
transcranial magnetic stimulation (TMS). Psychol Med 2000; 30:
565-70.
13. Þórisdóttir-Möller A, Hjaltason Ó, ívarsson Ó, Stefánsson SB.
Paired pulse transcranial magnetic stimulation shows increased
cortical inhibition in major depression (abstract). Læknablaöiö
2003; Suppl 48: P-31.
14. Amassian VE, Cracco RQ, Maccabee PJ, Cracco JB, Rudell
A, Eberle L. Suppression of visual perception by magnetic coil
stimulation of human occipital cortex. Electroencephalogr Clin
Neurophysiol 1989; 74:458-62.
15. Beckers G, Hömberg V. Cerebral visual motion blindness: trans-
itory akinetopsia induced by transcranial magnetic stimulation of
human area V5. Biol Scinece 1992; 249:173-8.
16. Meyer B-U, Diehl R, Steinmetz H, Britton TH, Benecke R.
Magnetic stimuli applied over motor and visual cortex: influence
of coil position and field polarity on motor responses, phosphen-
es, and eye movements. Electroencephalogr Clin Neurophysiol
1991; 43:121-34.
17. Aurora SK, Ahmad BK, Welch KM, Bhardhwaj P, Ramadan
NM. Transcranial magnetic stimulation confirms hyperexcitabi-
lity of occipital cortex in migraine. Neurology 1998; 50:1111-4.
18. Pascual-Leone A, Gates JR, Dhuna A. Induction of speech arr-
est and counting errors with rapid-rate transcranial magnetic
stimulation. Neurology 1991; 41: 697-702.
19. Stefánsson SB, Ólafsson E, Kjartansson Ó. Rannsókn á mál-
og minnisgetu flogaveikissjúklinga fyrir gagnaugablaðsaögerð,
Wada próf. Læknablaöið 1997; 83:16-9.
20. Töpper R, Mottaghy F, Briigmann M, Noth J, Huber W. Facilitat-
ion of picture naming by focal transcranial magnetic stimulation
of Wernicke’s area. Exp Brain Res 1998; 121:371-8.
21. Boroojerdi B, Phipps M, Kopylev L, Wharton CM, Cohen LG,
Grafman J. Enhancing analogic reasoning with rTMS over the
left prefrontal cortex. Neurology 2001; 56:526-8.
22. George MS, Ketter TA, Post RM. What functional imaging stud-
ies have revealed about the brain basis of mood and emotion,
in Advances in Biological Psychiatry. Edited by Panksepp J.
Greenwich, Conn, JAI Press 1996; 63-113.
23. Grunhaus L, Dannon PN, Schreiber S, Dolberg OH, Amiaz R,
Ziv R, et al. Repetitive transcranial magnetic stimulation is as
effective as electroconvulsive therapy in the treatment of nond-
elusional major depressive disorder: an open study. Biol Psyc-
hiatry 2000; 47:14-24.
24. Burt T, Lisanby SH, Sackeim H. Neuropsychiatric applications
of transcranial magnetic stimulation: a meta analysis. Int J Neu-
ropsychopharm 2002; 5: 73-103.
25. Martin JLR, Barbanoj MJ, Schlaepfer, Thompson E, Pérez V,
Kulisevsky J. Repetitive transcranial magnetic stimulation for
the treatment of depression. Brit J Psychiatry 2003; 182:480-91.
26. Macdonell RA. Curatolo JM, Berkovic SF. Transcranial magn-
etic stimulation and epilepsy. J Clin Neurophysiol 2002; 19: 294-
306.
27. Steinhoff BJ, Stodieck SRG, Paulus W, Witt TN. Transcranial
stimulation. Neurology 1992; 1992:1429-30.
28. Chokroverty S, Hening W, Wright D, Walczak T, Goldberg J,
Burger R. Magnetic brain stimulation: safety studies. Electroenc-
ephalogr Clin Neurophysiol 1995; 97:36-42.
29. Tergau F, Naumann U, Paulus W, Steinhoff BJ. Low-frequency
repetitive transcranial magnetic stimulation improves intractable
epilepsy. Lancet 1999; 353: 209.
30. Theodore WH, Hunter K, Chen R, Vega-Bermudez F, Borooj-
erdi B, Reeves-Tyer P, et al. Transcranial magnetic stimulation
for the treatment of seizures. A controlled study. Neurology
2002; 59:560-2.
31. Shiga Y, Tsuda T, Itoyama Y, Shimizu H, Miyazawa K-I, Jin K,
et al. Transcranial magnetic stimulation alleviates truncal ataxia
in spinocerebellar degeneration. J Neurol Neurosurg Psychiatry
2002; 72:124-6.
32. Þórisdóttir-Möller A, Andrésdóttir Þ, Sigurðsson AP, Bergmann
S, Stefánsson SB. Segulörvun hnykils í meðferð sjúklinga með
slingeinkenni (abstract). Læknablaðið 2002; 88/Suppl, 47:E 45.
33. Siebner HR, Mentsche C, Auer C, Conrad B. Repetitive tran-
scranial magnetic stimulation has a beneficial effect on bradyki-
nesia in Parkinson’s disease. Neuroreport 1999; 10: 589-94.
34. Hoffman RE, Boutros NN, Hu S, Berman RM, Krystal JH,
Charney DS. Transcranial magnetic stimulation and auditory
hallucinations in schizophrenia. Lancet 2000; 355:1073-5.
35. Möller AL, Hjaltason Ó, ívarsson Ó, Stefánsson SB. The eff-
ects of repetitive transcranial magnitic stimulation on depressive
symptoms and the P300 event-related potential. Nord J Psyc-
hiatry (submitted).
758 Læknablaðið 2004/90