Læknablaðið - 15.01.2008, Side 34

FRÆÐIGREINAR
TREFJAVEFSLUNGNABÓLGA
Mynd VII. Lifun sjúklinga
með trefjavefslungnabólgu í
samanburði við aldursstaðl-
að þýði á íslandi (5).
hverjir fá bakslag sjúkdóms síðar. Auk þess er erf-
itt að segja til um æskilegan byrjunarskammt stera
og hve lengi á að meðhöndla. Sjúkdómurinn er í
eðli sínu breytilegur og verður meðferðin ávallt að
stjórnast af því.
Þörf er á frekari vísindalegum rannsóknum
sem leiða til betri skilnings á meingerð sjúkdóms-
ins. Skilgreina þarf betur hvernig takmarkaður
viðgerðarferill í lungum breytist yfir í viðvarandi
bólguviðbrögð sem svara þó sterum.
Þakkir
Höfimdar þakka Inger Helene Bóasson ljósmynd-
ara aðstoð við myndvinnslu.
Heimildir
1. Colby TV. Pathologic aspects of bronchiolitis obliterans
organizing pneumonia. Chest 1992; 102: 38-43.
2. Davison AG, Heard BE, McAllister WAC, et al. Cryptogenic
organizing pneumonitis. Q J Med 1983; 52: 382-94.
3. Epler GR, Colby TV, McLoud TC, et al. Bronchiolitis
obliterans organizing pneumonia. N Engl J Med 1985; 312:
152-8.
4. American Thoracic Society/European Respiratory Society
Classification of the idiopathic interstitial pneumonias:
intemational multidisciplinary consensus. American Thoracic
Society/European Respiratory Society. Am J Respir Crit Care
Med 2002; 165: 277-304.
5. Guðmundsson G, Sveinsson ÓÁ, ísaksson HJ, et al.
Organizing pneumonia in Iceland. A nationwide population
based epidemiological study. Thorax 2006; 61: 805-8.
6. Sveinsson ÓÁ, ísaksson HJ, Guðmundsson G.
Trefjavefslungnabólga tengd notkun lyfsins amíódaón.
Sjúkratilfelli og yfirlit. Læknablaðið 2006; 92: 385-8.
7. Sveinsson ÓÁ, ísaksson, Sigvaldason A, et al. Clinical features
in secondary and cryptogenic organizing pneumonia. Int J
Tubercul Lung Dis 2007; 11: 989-94.
8. Nesheim M. Thrombin and fibrinolysis. Chest 2003; 124:
Suppl. 3,33-9.
9. Fujimoto H, Gabazza EC, Hataji O, et al. Thrombin-
activatable fibrinolysis inhibitor and protein C inhibitor in
interstitial lung disease. Am J Respir Crit Care Med 2003; 167:
1687-94.
10. Loskutoff DJ, Quigley JP. PAI-1, fibrosis, and the elusive
provisional fibrin matrix. J Clin Invest 2000; 106:1441-3.
11. Gunthe A, Lubke N, Ermert M, et al. Prevention of
bleomycin-induced lung fibrosis by aerosolization of heparin
or urokinase in rabbits. Am J Respir Crit Care Med 2003; 168:
1358-65.
12. Cordier J. Cryptogenic organising pneumonia. Eur Respir J
2006; 28: 422-46.
13. Lappi-Blanco E, Kaarteenaho-Wiik R, Soini Y, et al.
Intraluminal fibromyxoid lesions in bronchiolitis obliterans
organizing pneumonia are highly capillarized. Hum Pathol
1999; 30:1192-6.
14. Peyrol S, Cordier JF, Grimaud JA. Intra-alveolar fibrosis of
idiopathic bronchiolitis obliterans-organizing pneumonia.
Cell-matrix pattems. Am J Pathol 1990; 137:155-70.
15. Kuhn C 3rd, Boldt J, King TE, et al. An immunohistochemical
study of architectural remodeling and connective tissue
synthesis in pulmonary fibrosis. Am Rev Respir Dis 1989;
140:1693-703.
16. London L, Majeski EI, Paintlia MK, et al. Respiratory reovims
1/L induction of diffuse alveolar damage: a model of acute
respiratory distress syndrome. Exp Mol Pathol 2002; 72: 24-
36.
17. London L, Majeski EI, Altman-Hamamdzic S, et al. Respiratory
reovims 1/L induction of diffuse alveolar damage:
pulmonary fibrosis is not modulated by corticosteroids in
acute respiratory distress syndrome in mice. Clin Immunol
2002; 103: 284-95.
18. Epler GR. Drug-induced bronchiolitis obliterans organizing
pneumonia. Clin Chest Med 2004; 25: 89-94.
19. Valle JM, Alvarez D, Antunez J, et al. Bronchiolitis obliterans
organizing pneumonia secondary to amiodarone: a rare
aetiology. Eur Respir J 1995; 8: 470-1.
20. Camus P, Martin WJ 2nd. Rosenow EC 3rd. Amiodarone
pulmonary toxicity. Clin Chest Med 2004; 25: 65-75.
21. Camus P, Fanton Á, Bonniaud P, et al. Interstitial lung disease
induced by dmgs and radiation. Respiration 2004; 71: 301-
26.
22. Crestani B, Kambouchner M, Soler P, et al. Migratory
bronchiolitis obliterans organizing pneumonia after unilateral
radiation therapy for breast carcinoma. Eur Respir J 1995; 8:
318-21.
23. Crestani B, Valeyre D, Roden S, et al, and the Groupe d'Etudes
et de Recherche sur les Maladies Orphelines Pulmonaires
(GERM,,0,/P). Bronchiolitis obliterans organizing pneumonia
syndrome primed by radiation therapy to the breast. Am J
Respir Crit Care Med 1998; 158:1929-35.
24. Arbetter KR, Prakash UBS, Tazelaar HD, et al. Radiation-
induced pneumonitis in the "nonirradiated" lung. Mayo Clin
Proc 1999; 74: 27-36.
25. Cordier JF. Organising pneumonia. Thorax 2000; 55: 318-28.
26. Imasaki T, Yoshii A, Tanaka S, et al. Polymyositis and
Sjogren's syndrome associated with bronchiolitis obliterans
organizing pneumonia. Intem Med 1996; 35: 231-5.
27. Rees JH, Woodhead MA, Sheppard MN, et al. Rheumatoid
arthritis and cryptogenic organising pneumonitis. Respir
Med 1991; 85: 243-6.
28. Gammon RB, Bridges TA, al-Nezir H, et al. Bronchiolitis
obliterans organizing pneumonia associated with systemic
lupus erythematosus. Chest 1992; 102:1171-4.
29. Lohr RH, Boland BJ, Douglas WW, et al. Organizing
pneumonia: features and prognosis of cryptogenic, secondary,
and focal variants. Arch Intem Med 1997; 157:1323-9.
30. Costabel U, Teschler H, Guzman J. Bronchiolitis obliterans
organizing pneumonia (BOOP): the cytological and
immunocytological profile of bronchoalveolar lavage. Eur
Respir J 1992; 5: 79-7.
31. Poletti V, Cazzato S, Minicuci N, et al. The diagnostic value
of bronchoalveolar lavage and transbronchial lung biopsy
in cryptogenic organizing pneumonia. Eur Respir J 1996; 9:
2513-6.
32. Nagai S, Aung H, Tanaka S, et al. Bronchoalveolar lavage cell
findings in patients with BOOP and related diseases. Chest
1992; 102: Suppl. 1/ 32-7.
33. Preidler KW, Szolar DM, Moelleken S, et al. Distribution
pattern of computed tomography findings in patients with
bronchiolitis obliterans organizing pneumonia. Invest Radiol
1996; 31:251-5.
34. Fukuda Y, Ishizaki M, Masuda Y, et al. The role of
intraalveolar fibrosis in the process of pulmonary stmctural
remodeling in patients with diffuse alveolar damage. Am J
Pathol 1987; 126:171-82.
35. Svee K, White J, Vaillant P, et al. Acute lung injury fibroblast
migration and invasion of a fibrin matrix is mediated by
CD44. J Clin Invest 1996; 98:1713-27.
34 LÆKNAblaðið 2008/94